《药理学》课程PPT教学课件（Antimicrobial Drugs）39 Inhibitors of Cell Wall Synthesis

Inhibitors of Cell Wall Synthesis

Inhibitors of Cell Wall Synthesis

Inhibitors of Cell Wall Synthesis1.Overview2. Penicillins3.Cephalosporins4.Carbapenems and Monobactams5.Vancomycin and Bacitracin

Inhibitors of Cell Wall Synthesis 1. Overview 2. Penicillins 3. Cephalosporins 4. Carbapenems and Monobactams 5. Vancomycin and Bacitracin

The classification of β lactamantibioticsI PenicillinsNarrowspectrumpenicillinsPenicillinase-resistant penicillins2.Broad spectrum penicillins3Broad spectrum penicillins againstpseudomonasaeruginosaPenicillins against G5

The classification of β－lactam antibiotics I Penicillins 1. Narrow spectrum penicillins 2. Penicillinase-resistant penicillins 3. Broad spectrum penicillins 4. Broad spectrum penicillins against pseudomonas aeruginosa 5. Penicillins against G-

II CephalosporinsThe firstgeneration cephalosporins;.The second generation cephalosporinsThethirdgenerationcephalosporins;.The fourth generation cephalosporins

II Cephalosporins • The first generation cephalosporins; • The second generation cephalosporins; • The third generation cephalosporins; • The fourth generation cephalosporins

IIIOther β-lactamsCephamycins·CarbapenemsMonobactamsOxacephemsIV β-lactamase inhibitorV Combination β-lactam antibiotics

III Other β－lactams • Cephamycins • Carbapenems • Monobactams • Oxacephems IV β－lactamase inhibitor V Combination β－lactam antibiotics

1. OVERVIEW

1. OVERVIEW

Gram-negative BacterialMembrane StructureCell MembranePeptidoglycanCytoplasmicMembrane

Cell Membrane Peptidoglycan Cytoplasmic Membrane Gram-negative Bacterial Membrane Structure

Gram-positive BacterialMembrane StructurePeptidoglycanLayers.CytoplasmicMembrane

Peptidoglycan Layers Cytoplasmic Membrane Gram-positive Bacterial Membrane Structure

The Cell WallIt is madeof peptidoglycans.Gram-positivebacteriahaveanenvelopeofupto40layersofpeptidoglycans,to containaninternal osmotic pressure ofabout 20 atmGram-negative bacteria have an internal pressureof about5atm, and have thinner wallsThe cell wall is specific to bacteria, and indispensable to theirsurvival

The Cell Wall It is made of peptidoglycans. Gram-positive bacteria have an envelope of up to 40 layers of peptidoglycans, to contain an internal osmotic pressure of about 20 atm Gram-negative bacteria have an internal pressure of about 5 atm, and have thinner walls The cell wall is specific to bacteria, and indispensable to their survival

PeptidoglycansThecell wall is anetworkofpeptidoglycans-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-N-NAMA-NAGNAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA.-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-NAMA-NAG-NA-NAMA-NAG-NAMA-NAG-NAMA-NAG=N-acetylmuramic acid; NAMA=N-acetylglucosamine (amino sugars)=tetrapeptidechain=5glycineresidues linkingthepeptidechains

Peptidoglycans The cell wall is a network of peptidoglycans