《药理学》课程PPT教学课件（Antimicrobial Drugs）38 Principles of Antimicrobial Therapy

Principles ofAntimicrobial Therapy

Principles of Antimicrobial Therapy

I.OverviewAntimicrobialdrugs are effective in thetreatment ofinfection because of their selectivetoxicity-the abilityto kill an invadingmicroorganism without harming the cells of thehost

I. Overview Antimicrobial drugs are effective in the treatment of infection because of their selective toxicity- the ability to kill an invading microorganism without harming the cells of the host

Selective antimicrobial therapy takesadvantage of the biochemical differences thatexist between microorganisms and human beings

Selective antimicrobial therapy takes advantage of the biochemical differences that exist between microorganisms and human beings

chemotherapyIt is to use chemistry drugs treating orpreventing the diseases caused bypathogenic microbe, helminth orcancer cell

chemotherapy It is to use chemistry drugs treating or preventing the diseases caused by pathogenic microbe, helminth or cancer cell

ChemotherapeuticAgentsantimicrobial drugsantibacterial drugsantifungal drugsantiviral drugsanthelmintic drugsanticancer drugs

Chemotherapeutic Agents • antimicrobial drugs antibacterial drugs antifungal drugs antiviral drugs • anthelmintic drugs • anticancer drugs

Perfect antibacterial drug: High selectivity to pathogen? Pathogenic germs' resistance is broughtdifficultlyAdverse action is littlePharmacokinetics' condition is good Character of physics and chemistry is stable. Usage is convenient and price is cheap

Perfect antibacterial drug • High selectivity to pathogen • Pathogenic germs’ resistance is brought difficultly . • Adverse action is little. • Pharmacokinetics’ condition is good. • Character of physics and chemistry is stable. • Usage is convenient and price is cheap

Basic concepts01antibacterial drug?大?

Basic concepts of antibacterial drug

Antibacterial drug ?Antibacterial drugs are substances toinhibit or kill bacteria and to prevent andcure the bacteroidal inflammationantibacterial drugSyntheticantibioticsnaturel~semisynthetic

Antibacterial drug？ • Antibacterial drugs are substances to inhibit or kill bacteria and to prevent and cure the bacteroidal inflammation . antibiotics naturel～ semisynthetic ～ antibacterial drug synthetic ～

Antibacterial spectrum. Antibacterial spectrum of a drug meansthe species of microorganisms that the drugcan inhibit or killNarrow spectrum:for example, isoniazidBroad spectrum:for example, tetracyclinesand chloramphenicol

Antibacterial spectrum • Antibacterial spectrum of a drug means the species of microorganisms that the drug can inhibit or kill. Narrow spectrum：for example, isoniazid Broad spectrum： for example, tetracyclines and chloramphenicol

antibacterial activity It means the ability of a drug thatthe drug can inhibit or killmicroorganisms

antibacterial activity • It means the ability of a drug that the drug can inhibit or kill microorganisms