重庆医科大学：《病理学》课程教学课件（PPT讲稿）cardiovascular system disease

圈重走普科大子 hongqing Medicol University Cardiovascular System Disease Depart.of Pathol.CQMU

Atherosclerosis (ATH) 1.Definition Atherosclerosis is a disease of large and medium sized arteries,characterised by lipid deposition and fibrosis

Atherosclerosis (ATH) 1.Definition Atherosclerosis is a disease of arteries, characterised by

2.Aetiology Risk factors ●Hyperlipidemia LDL (Low density lipoprotein) HDL (High density lipoprotein) ●Hypertension ● Smoking ● Diabetes ● coexistence LDL,obesity, hypertension hyperlipidemia Others Age Genetic factors

2.Aetiology Risk factors l Hyperlipidemia LDL (Low density lipoprotein)↑ HDL (High density lipoprotein)↓ l Hypertension l Smoking l Diabetes l coexistence LDL , obesity, hypertension ,hyperlipidemia l Others : Age Genetic factors

重废骑大净 3.Pathogenesis Most theories invoke some damage to endothelium or underlying smooth muscle blood lipid 1 endothelial permeability increased

3. Pathogenesis Most theories invoke some damage to endothelium or underlying smooth muscle . blood lipid ↑ endothelial permeability increased

重蹇等科大学 thongqing Medicol University smooth muscle migration from media to intima,followed by proliferation. Monocytes phagocytize lipid and Smooth muscle cells also phogocytosis (lipid)-foam cells (the fatty streak) Smooth muscle cells synthesize extracellular matrix (the fibrous plaque) the lipid release by necrotic foam cells mixed with necrotic tissues (atheromatous plaque)

smooth muscle migration from media to intima, followed by proliferation. Monocytes phagocytize lipid and Smooth muscle cells also phogocytosis (lipid)-foam cells (the fatty streak) Smooth muscle cells synthesize extracellular matrix (the fibrous plaque) the lipid release by necrotic foam cells mixed with necrotic tissues (atheromatous plaque)

4.Pathologic change Morphology) (1)Fatty streak Gross:flat or slightly elevated lesion,yellow- color in the intima Microscope:subendothelial foam cells which mainly of smooth muscle cells and macrophages origin

4.Pathologic change ( Morphology) (1)Fatty streak Gross: flat or slightly elevated lesion, yellow- color , in the intima Microscope: subendothelial foam cells which mainly of smooth muscle cells and macrophages origin

圈重走普种大子 hongqing Medicol University (2)Fibrous plaque Gross:yellow white elevation/or waxy white Microscope:three zone fibrous cap -smooth muscle cells -scattered leukocytes dense collagen

重麦骑什大净 Chongqing Medical University (3)Lipid zone extracellular lipid Basal zone ■foam cells extracellular lipid (cholesterol crystals) SMC

重蹇等科大學 Chongqing Medicol University (4)Atheromatous plaque called as atheroma Gross: -The soft yellow nodules Microscope -fibrous cap -necrotic tissue,free fat and visible cholesterol crystals -granular tissue,few foam cells and lymphocytes

5.Complicated lesion Hemorrhage into the plaques Rupture of the plaques -ulceration thrombosis Calcification Formation of an aneurysm

5.Complicated lesion Hemorrhage into the plaques Rupture of the plaques -ulceration thrombosis Calcification Formation of an aneurysm