重庆医科大学：《病理学》课程教学课件（PPT讲稿）Epidemic Meningitis

网 重麦等科大昂 hongging Medical University Diseases of the nervous system Depart.of Pathol.CQUM

Diseases of the nervous system Depart. of Pathol. CQUM

重蹇路科大骨 hongqing Medical University Subarachnoid space arachnoid Subarachnoid granule Choroid plexus (CSF formation) leptomeninge

Subarachnoid space Choroid plexus (CSF formation) Subarachnoid granule leptomeninge arachnoid

重蹇等科大学 ongging Medical University The CNS consists of -Neurons cell body,cytoplasmic processes,nucleus, Nissl substance -Neuroglial cells astrocytes oligodendroglia microglia

The CNS consists of -Neurons cell body, cytoplasmic processes, nucleus, Nissl substance -Neuroglial cells astrocytes oligodendroglia microglia

烟童走华利大 gqing Med山eal University Classification of infections: Infection of meningeal (meningitis) Infection of cerebral and spinal parenchyma (encephalitis or myelitis) Infective route: Hematogenous spread-infective endocarditis Direct infection-trauma Local extension-frontal sinusitis,infection of the middle ear and mastoid sinuses

Classification of infections: ◼ Infection of meningeal (meningitis) ◼ Infection of cerebral and spinal parenchyma (encephalitis or myelitis) Infective route: ◼ Hematogenous spread-infective endocarditis ◼ Direct infection-trauma ◼ Local extension– frontal sinusitis, infection of the middle ear and mastoid sinuses

重蹇等科大学 ongging Medical University Meningeal infection Inflammation of the leptomeninges and subarachnoid Classification: -purulent meningitis:bacteria -lymphocytic meningitis:virus -chronic meningitis:different agents,TB

Meningeal infection Inflammation of the leptomeninges and subarachnoid Classification: -purulent meningitis: bacteria -lymphocytic meningitis: virus -chronic meningitis: different agents, TB

Epidemic Meningitis A purulent infection of the pia mater (leptomeninges)and arachnoid caused by neisseria meningitides The bacteria is inhaled through the respiratory tract nasopharynx infection bacteria enter the bloodstream and meninges

Epidemic Meningitis A purulent infection of the pia mater (leptomeninges) and arachnoid caused by neisseria meningitides The bacteria is inhaled through the respiratory tract nasopharynx infection bacteria enter the bloodstream and meninges

圈 重麦等科大学 ongging Medical University Epidemic in winter and spring About 70%of all cases in children under 5 yrs of age ■ acute onset,rapid clinical course

◼ Epidemic in winter and spring ◼ About 70% of all cases in children under 5 yrs of age ◼ acute onset, rapid clinical course

國重走晋种大 gqing Med山eal Universi 1.Pathology Grossly congested and opaque leptomeninges diffuse greyish-yellow pus in the subarachnoid space

1.Pathology Grossly ◼ congested and opaque leptomeninges ◼ diffuse greyish-yellow pus in the subarachnoid space

网 重麦等科大 nongging Medical University Microscopically Hyperemia Purulence in subarachnoid space Fibrin and neutrophils exudate Severe case:superficial foci of brain edema,degeneration of neurons

Microscopically ◼ Hyperemia ◼ Purulence in subarachnoid space ◼ Fibrin and neutrophils exudate Severe case： superficial foci of brain edema, degeneration of neurons

圈市走普种大学 ongqins里Med山eal University