重庆医科大学：《病理学》课程教学课件（PPT讲稿）tissue repair

)重麦等科大星 honggin里Medic四I University Tissue Repair Depart.Of Pathol.CQMU

Tissue Repair Depart. Of Pathol. CQMU

圈童走冬种大子 nongqing Medical University Regeneration Regeneration enables cells or tissue destroyed by injury or disease to be replaced by functionally identical cells. The ability of cells to proliferate governs their regenerative potential. Mammalian cells fall into three classes according to their regenerative ability. -Labile -Stable -Permanent

Regeneration ⚫Regeneration enables cells or tissue destroyed by injury or disease to be replaced by functionally identical cells. ⚫The ability of cells to proliferate governs their regenerative potential. ⚫Mammalian cells fall into three classes according to their regenerative ability. –Labile –Stable –Permanent

重麦等科大 Labile cells:This sub-population of cells is constantly turned over.The best examples are found in the epithelial cell population of the skin or gut,and the hematopoetic cells in the bone marrow. These cells have a short,finite life span, die via apoptosis,and are rapidly replaced

⚫ Labile cells: This sub-population of cells is constantly turned over. The best examples are found in the epithelial cell population of the skin or gut, and the hematopoetic cells in the bone marrow. These cells have a short, finite life span, die via apoptosis, and are rapidly replaced

重麦暗科大学 gqing Med山eal Universi Stable cells:Stable cells are a sub- population of cells that are normally replaced very slowly,but are capable of rapid renewal after tissue loss.Hepatocytes and the proximal convoluted tubule cells of the kidney are good examples

⚫ Stable cells: Stable cells are a sub￾population of cells that are normally replaced very slowly, but are capable of rapid renewal after tissue loss. Hepatocytes and the proximal convoluted tubule cells of the kidney are good examples

重麦等科大 ongging Medical University o Permanent cells:Permanent cells are found in the central nervous system and heart. Once they are destroyed,they cannot regenerate

⚫ Permanent cells: Permanent cells are found in the central nervous system and heart. Once they are destroyed, they cannot regenerate

重蹇暗科大学 gqing Med山eal Univer some examples Continuously dividing (labile)cells Stratified epithelia of skin,oral cavity,vagina, cervix;cuboidal epithelia of exocrine ducts; columnar epithelium of GI tract,uterus; transitional epithelium of bladder;hematopoietic cells Quiescent (stable)cells Parenchymal cells of liver,kidney,pancreas; endothelial cells,smooth muscle,fibroblasts Nondividing (permanent)cells -Nerve cells,cardiac myocytes,skeletal muscle

Continuously dividing (labile) cells – Stratified epithelia of skin, oral cavity, vagina, cervix; cuboidal epithelia of exocrine ducts; columnar epithelium of GI tract, uterus; transitional epithelium of bladder; hematopoietic cells Quiescent (stable) cells – Parenchymal cells of liver, kidney, pancreas; endothelial cells, smooth muscle, fibroblasts Nondividing (permanent) cells – Nerve cells, cardiac myocytes, skeletal muscle some examples :

重麦等科大星 hongging Medical University 1.The regenerative process of several tissues The process of regeneration can be divided into two main Components: Movement of surviving cells into the vacant space made available by loss due to wounding or necrosis. Proliferation of surviving cells to replace the loss

1.The regenerative process of several tissues The process of regeneration can be divided into two main Components: ⚫ Movement of surviving cells into the vacant space made available by loss due to wounding or necrosis. ⚫ Proliferation of surviving cells to replace the loss

国重走等种大学 nongqing Medical University 1)Epithelial tissue Squamous epithelium:The dividing basal cells Mucosal epithelium:Viable epithelium cells Glandular epithelium:Surviving glandular cells All of them are complete regeneration

1）Epithelial tissue Squamous epithelium:The dividing basal cells Mucosal epithelium:Viable epithelium cells Glandular epithelium:Surviving glandular cells All of them are complete regeneration

重麦路科大 ongqing Medical University 2)Fibrous tissue FIBROCYTES (and primitive cells) situated around capillaries and loose connective tissues Enlarge to become active SECRETION OF FIBROBLASTS PROCOLLAGEN Condensation to form RETICULIN fibres· Condensation to form COLLAGEN fibres. Bonding and weaving SCAR TISSUE Reversion to FIBROCYTES

2）Fibrous tissue

重蹇暗科大星 ongqing Med山eal Univers 3)Blood vessel DCapillary and small blood vessel Proliferation of blood vessel endothelial cells into the damaged area- +form solid buds canalise thin- walled capillaries. 2Large blood vessel Endothelial cells can complete regenerate;but the muscle cannot regenerate,it can be replaced by fibrous tissue

3）Blood vessel ①Capillary and small blood vessel : Proliferation of blood vessel endothelial cells into the damaged area form solid buds canalise thin￾walled capillaries. ②Large blood vessel :Endothelial cells can complete regenerate; but the muscle cannot regenerate,it can be replaced by fibrous tissue