重庆医科大学：《病理学》课程教学课件（PPT讲稿）lymphoma

圈童走冬种大子 ongqing Medical University Disease of Hematopoietic and lymphoid system Depart.of Pathol.CQMU

Disease of Hematopoietic and lymphoid system Depart. of Pathol. CQMU

重蹇等科大学 ongging Medical University Malignant lymphoma Classification 1.Hodgkin's lymphoma,HL Hodgkin's Disease,HD 2.Non-Hodgkin's lymphoma,NHL B-cell neoplasms T and NK-cell neoplasms tumors of histiocyte and dendratic cells

Classification 1. Hodgkin’s lymphoma, HL Hodgkin’s Disease, HD 2. Non-Hodgkin’s lymphoma,NHL B-cell neoplasms T and NK-cell neoplasms tumors of histiocyte and dendratic cells Malignant lymphoma

重废特科大昂 ngqing Medical University Hodgkin's lymphoma,HL Hodgkin's Disease,HD HL is a unique malignant tumor originating in the lymphoid tissue that feature characteristic Reed-Sternberg cells and mixed with a variable inflammatory infiltrate. Evidence is now accumulating that HL is tumor of B lymphocytes

Hodgkin’s lymphoma, HL Hodgkin’s Disease, HD ◼ HL is a unique malignant tumor originating in the lymphoid tissue that feature characteristic Reed-Sternberg cells and mixed with a variable inflammatory infiltrate. ◼ Evidence is now accumulating that HL is tumor of B lymphocytes

重麦等科大昂 nongging Medical University 1.Pathologic change Gross appearance Affected lymph nodes are enlarged.Cut surface is homogeneously gray-white (fish-flesh appearance)

Gross appearance Affected lymph nodes are enlarged. Cut surface is homogeneously gray-white (fish-flesh appearance) 1.Pathologic change

重蹇普科大学 ongqins里Med山eal Univers 2.Histologic morphology:archetecture of lymph node partially or completely demolished cells tumor cells -Reed-Sternberg(R-S)cell and its variants reactive inflammatory cells: lymphocytes eosinophils histocytes fibrocytes and fibroblasts

2. Histologic morphology: archetecture of lymph node partially or completely demolished cells ◼ tumor cells - Reed-Sternberg( R-S) cell and its variants ◼ reactive inflammatory cells: lymphocytes eosinophils histocytes fibrocytes and fibroblasts

重蹇普科大学 ongging Medical University RS Cell is a large cell.The nuclei are large.There are binucleus or multiple nucleus with large,round prominent nucleoli. Binucleate appearance with prominent nucleoli-Classic RS Cell. Variants of R-S cell Mononuclear RS Cell (mononuclear Hodgkin's cell) Lacunar cell is a large cell with nucleus containing small nucleoli and an abundant,pale-staining cytoplasm.(the appearance of cell -lie within a cleared space). Popcorn cell Delicate multilobed,puffy nucleus that has been likened in appearance to popcorn

RS Cell is a large cell. The nuclei are large. There are binucleus or multiple nucleus with large , round prominent nucleoli. Binucleate appearance with prominent nucleoli-Classic RS Cell. Variants of R-S cell • Mononuclear RS Cell (mononuclear Hodgkin`s cell) • Lacunar cell is a large cell with nucleus containing small nucleoli and an abundant, pale-staining cytoplasm. (the appearance of cell - lie within a cleared space). • Popcorn cell Delicate multilobed, puffy nucleus that has been likened in appearance to popcorn

倒童走等升大 Chongqing Medical University Classic RS Cell-Mirror image nuclei contain large eosinophilic nucleoli

Classic RS Cell — Mirror image nuclei contain large eosinophilic nucleoli

网 重蹇等科大星 Subtypes of Hodgkin lymphoma lymphocyte-predominant,LP mixed cellularity,MC lymphocyte depletion,LD nodular sclerosis,NS

Subtypes of Hodgkin lymphoma ◼ lymphocyte-predominant, LP ◼ mixed cellularity, MC ◼ lymphocyte depletion, LD ◼ nodular sclerosis, NS

國重走晋种大学 gqing Med山eal Univer (1)lymphocyte-predominant, LP 10% Abundant lymphocytes,scanty RS cells, scattering of popcorn cells

(1)lymphocyte-predominant, LP 10% Abundant lymphocytes, scanty RS cells, scattering of popcorn cells

重麦等科大昂 ongging Medical University (2)mixed cellularity,MC ■30-60% ■ Classic RS cell,lymphocytes,eosinophils, plasma cells,and histocytes

(2)mixed cellularity, MC ◼ 30~60% ◼ Classic RS cell, lymphocytes, eosinophils, plasma cells, and histocytes