《线粒体生物学与医学》课程教学课件（Mitochondria Biology and Medicine）1 线粒体代谢——营养与健康的秘密（西安交通大学：龙建纲）

目录contents口细胞与线粒体Cell and Mitochondria线粒体复合物MitochondriaComplex-线粒体与疾病Mitochondrial related diseases口线粒体营养素Mitochondrial Nutrients

目 录 contents  细胞与线粒体 Cell and Mitochondria  线粒体复合物Mitochondria Complex  线粒体与疾病 Mitochondrial related diseases  线粒体营养素 Mitochondrial Nutrients

：细胞与线粒体一CELL AND MITOCHONDRIA

一、细胞与线粒体 CELL AND MITOCHONDRIA

仰观宇宙之大Frominfinitesimaltoinfinitesima船底座伊塔星和星云猎户座一等星大角星北河三天狼星太阳（1像素）雄牛座一等星参宿七

4 仰观宇宙之大 From infinitesimal to infinitesima

从夸克到统一宇宙FromQuarktoUnifieduniverse

5 从夸克到统一宇宙 From Quark to Unified universe

200萬：人美生45.52.3-0.65值：人类出现2恐恐龙去哪儿了？约3.8镜陆生脊椎物逢生.多用用生学海洋哺乳动物？真检推的5.3度原捷用单纪大爆登67.5-6.35他水生→陆生？的40俺：月球炎结束：二次雪球地球生命潼生中生代叉古宙40值约35俺：7光合作用朋始俯察品类之盛显生宙10使元古宙早?30吨隐生宙约23倍：大氧富含氧氟：

水生→陆生？ 恐龙去哪儿了？ 海洋哺乳动物？ 隐生宙 显生宙 人类出现？ 俯 察 品 类 之 盛

“生命和能量是手牵手走来的”Life and energy come hand in hand生命最基本要素：结构+能量=》生命Essential component of life:Structure+Energy

“生命和能量是手牵手走来的” Life and energy come hand in hand 生命最基本要素: 结构+能量=》生命’ Essential component of life: Structure + Energy

细胞与线粒体Cell & MitochondriaCURUS4MitochondrionInnerMembrane

细胞与线粒体 Cell & Mitochondria 9

MatrixInnermembranOutermembraneIntermembranespaceFigure14-8part2of3.MolecularBiologyoftheCell,4thEdition.100nmFigure14-8part1of3.MolecularBiologyoftheCell,4thEditionTextbookEM and cartoons of mitochondria.Mitochondria havetwo membrane--innerand outer, and two compartments--matrix and inner membrane space.10

Textbook EM and cartoons of mitochondria. Mitochondria have two membrane-inner and outer, and two compartments-matrix and inner membrane space. 10

细胞中的线粒体数目Mitochondria population in a cell*体细胞Mostsomaticcells100-10.0001000*淋巴细胞Lymphocyte*心肌细胞Cardiocyte5,000-10,000100,000*卵细胞Oocytes*精细胞SpermFew hundred成熟红细胞和分化的皮肤细胞没有线粒体Nomitochondriainredcellsandsometerminallydifferentiatedskin cells

11 细胞中的线粒体数目 Mitochondria population in a cell  体细胞 Most somatic cells 100-10,000  淋巴细胞Lymphocyte 1000  心肌细胞Cardiocyte 5,000-10,000  卵细胞Oocytes 100,000  精细胞Sperm Few hundred 成熟红细胞和分化的皮肤细胞没有线粒体 No mitochondria in red cells and some terminally differentiated skin cells