《药理学》课程教学资源（试卷习题）examination paper B（含答案）

Examination paper of (pharmacology)for the the second term of 2005-2006 academic year of Chongqing medical university Mode of the examination:closed,Time for the examination:90 minutes The grade and the subject which the examination paper be applied grade 2006, medical science Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey "The role of the examination room of chongqingmedical university"rigoroursly.The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out "The rule of the task and responsibility in the examinations"rigoroursly."The additional rule of the further specification of the task in the examinations "and ensure the order of the examination room by carry out "The responsibility of the supervisior of chongqing medical university"seriously. Question number Total marks Score Sign by appraiser 1.Type A:(DIRECTIONS:Each question below contains five suggested answers. Choose the best one response to each question.The marks of each question is 1,totally 70 marks): 1.The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 】 A.the peak blood concentration B.the time that is needed for drug to arrive at peak blood concentration after administration C.volume of distribution D.the first-order rate constant

1 Examination paper of《pharmacology》for the the second term of 2005—2006 academic year of Chongqing medical university Mode of the examination：closed， Time for the examination：90 minutes The grade and the subject which the examination paper be applied ： grade 2006， medical science. Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey “The role of the examination room of chongqingmedical university”rigoroursly. The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out “The rule of the task and responsibility in the examinations ”rigoroursly,“The additional rule of the further specification of the task in the examinations ”and ensure the order of the examination room by carry out“The responsibility of the supervisior of chongqing medical university”seriously. Question number Ⅰ Ⅱ Ⅲ Ⅳ Total marks Score Sign by appraiser I.Type A：（DIRECTIONS: Each question below contains five suggested answers. Choose the best one response to each question. The marks of each question is 1，totally 70 marks）: 1. The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 】 A. the peak blood concentration B. the time that is needed for drug to arrive at peak blood concentration after administration C. volume of distribution D. the first-order rate constant College or department class and grade name student number

E.the area under the blood concentration-time curve 2.After given orally.which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 】 A.acetaminophen,weak acid,pKa 9.5 B.aspirin,weak acid,pKa 3.5 C.phenobarbital.weak acid.pKa 8.1 D.atropine.weak base.pKa 9.7 E.clonidine.weak base,pKa 8.3 3.If a drug has an elimination half time (t)of 24 hours and 10 mg is administered intravenously once daily.how many days are needed at least for the drug to arrive at Css? 【 】 A.1 day B.3 days C.5 days D.7 days E.9 days 4.The characteristics of simple diffusion of drugs include the fol lowing items EXCEPT【 】 A.No energy is neededB.No carrier is needed C.Transportation is concentration-dependence existing on two sides of the transport regions D.It is also called down hill E.The pH value of transportation surroundings has no influence on it 5.The onset and duration of action of barbiturates are mainly a function of its【 】 A.lipid solubility B.molecular weight C.plasma protein binding D.renal excretion E.method of administration 6.The drug of choice for the treatment of anaphylactic shock is 】 A.histamine B.adrenaline C.noradrenaline D.isoproterenol E.diphenhydramine 2

2 E. the area under the blood concentration-time curve 2. After given orally, which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 【 】 A. acetaminophen, weak acid, pKa 9.5 B.aspirin, weak acid, pKa 3.5 C.phenobarbital, weak acid, pKa 8.1 D.atropine, weak base, pKa 9.7 E.clonidine, weak base, pKa 8.3 3. If a drug has an elimination half time (t1/2) of 24 hours and 10 mg is administered intravenously once daily, how many days are needed at least for the drug to arrive at Css? 【 】 A.1 day B.3 days C.5 days D.7 days E.9 days 4. The characteristics of simple diffusion of drugs include the following items EXCEPT 【 】 A. No energy is neededB. No carrier is needed C.Transportation is concentration-dependence existing on two sides of the transport regions D.It is also called down hill E.The pH value of transportation surroundings has no influence on it 5. The onset and duration of action of barbiturates are mainly a function of its 【 】 A.lipid solubility B.molecular weight C.plasma protein binding D.renal excretion E.method of administration 6. The drug of choice for the treatment of anaphylactic shock is 【 】 A.histamine B.adrenaline C.noradrenaline D.isoproterenol E.diphenhydramine

7.Functionally.a patient with myasthenia gravis resembles a person who has been treated with low doses of 】 A.atropine B.tubocurarine C.methachol ine D.muscarine E.propranolol 8.Which of following mechanisms is responsible for el imination of endogenous acetylcholine? 【 】 A.the enzyme called choline acetyltransferase B.the enzyme called acetylcholinesterae C.the uptake by peripheral tissues D.the uptake by nerve endings E.the excretion by kidneys 9.A predictably dangerous side effect of propranolol is[ 】 A.inducting hypertension B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 10.Which of fol lowing drugs is suitable for patients with hypertensive crisis? A.clonidine B.prazosin C.sodium nitroprusside D.nifedipine E.hydrochlorothiazide 11.Ba-adrenergic receptor is involved in which of the following adrenergic responses【 】 A.stimulatiing myocardial contractility B.relaxing bronchial smooth muscle C.increasing heart rate D.contracting gastrointestinal smooth muscle E.improving microcirculation 12.The characteristics of hepatic drug enzymes include the fol lowing items EXCEPT【 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist 3

3 7. Functionally, a patient with myasthenia gravis resembles a person who has been treated with low doses of 【 】 A.atropine B.tubocurarine C.methacholine D.muscarine E.propranolol 8. Which of following mechanisms is responsible for elimination of endogenous acetylcholine? 【 】 A.the enzyme called choline acetyltransferase B.the enzyme called acetylcholinesterae C.the uptake by peripheral tissues D.the uptake by nerve endings E.the excretion by kidneys 9. A predictably dangerous side effect of propranolol is 【 】 A.inducting hypertension B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 10. Which of following drugs is suitable for patients with hypertensive crisis? 【 】 A. clonidine B.prazosin C.sodium nitroprusside D.nifedipine E.hydrochlorothiazide 11. 2-adrenergic receptor is involved in which of the following adrenergic responses 【 】 A.stimulatiing myocardial contractility B. relaxing bronchial smooth muscle C.increasing heart rate D.contracting gastrointestinal smooth muscle E.improving microcirculation 12. The characteristics of hepatic drug enzymes include the following items EXCEPT 【 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist

C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 13.Which of the fol lowing drugs is an antagonist of angiotension II receptor A.captopril B.phentolamine C.losartan D.hydralazine E.minoxidil 14.Which of following drugs can induce the attack of angina pectoris 【 】 A.clonidine B.propranolol C.hydrochlorothiazide D.candisartan E.hydralazine 15.Which of following drugs is selectively adrenergic Ba receptor agonist? 【 】 A.terbutaline B.ephedrine C.isoprenaline D.dopamine E.aminophylline 16.The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? A.chlorpromazine B.diazepam C.succinylchol ine D.ethosuximide E.phenytoin 17.Vasodi lation can be caused by fol lowing drugs EXCEPT A.verapamil B.phentolamine C.prasozin D.propranolol E.aminophylline 18.Which of following drugs is suitable to treat the shock patients with insufficiencies of renal and cardiac function? 【 】 A.terbutaline B.ephedrine C.ipratropinum D.atropine E.dopamine 19.Which of following drugs is very suitable to treat hypertensive patients with anxiety and alimentary ulcers 【 】 A.hydralazine B.clonidine C.propranolol D.nifedipine E.captopril 20.Following drugs may overturn the elevation of blood pressure caused by adrenaline when they are used in combination of adrenaline EXCEPT 【 A.phentolamine B.prazosin C.chlorpromazine D.atropine E.imipramine 21.The good candidate for treatment of depression is 】 4

4 C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 13. Which of the following drugs is an antagonist of angiotension II receptor 【 】 A.captopril B.phentolamine C.losartan D.hydralazine E.minoxidil 14. Which of following drugs can induce the attack of angina pectoris 【 】 A.clonidine B.propranolol C.hydrochlorothiazide D.candisartan E.hydralazine 15. Which of following drugs is selectively adrenergic 2 receptor agonist? 【 】 A.terbutaline B.ephedrine C.isoprenaline D.dopamine E.aminophylline 16. The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? 【 】 A. chlorpromazine B.diazepam C.succinylcholine D.ethosuximide E.phenytoin 17. Vasodilation can be caused by following drugs EXCEPT 【 】 A.verapamil B.phentolamine C.prasozin D.propranolol E.aminophylline 18. Which of following drugs is suitable to treat the shock patients with insufficiencies of renal and cardiac function? 【 】 A.terbutaline B.ephedrine C.ipratropinum D.atropine E. dopamine 19. Which of following drugs is very suitable to treat hypertensive patients with anxiety and alimentary ulcers 【 】 A.hydralazine B.clonidine C.propranolol D.nifedipine E.captopril 20. Following drugs may overturn the elevation of blood pressure caused by adrenaline when they are used in combination of adrenaline EXCEPT 【 】 A.phentolamine B.prazosin C.chlorpromazine D.atropine E.imipramine 21.The good candidate for treatment of depression is 【 】

A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 22.Chlorpromazine can be used to treat nausea and vomiting caused by many factors EXCEPT for【 】 A.digoxin B.radiation C.pregnancy D.motion sickness E.morphine 23.The good candidate for treatment of asphyxia of newborn baby is 【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 24.The use of morphine is contraindicated in A.myocardial infarction B.acute pulmonary edema C.simple diarrhea D.kidney colic E.bronchial asthma 25.The major pharmacological mechanism of naloxone is A.exciting the u receptor B.antagonizing the u receptor C.exciting the a receptor D.exciting the B receptor E.blockage of M receptor 26.Which drug below dose not belong to narcotic analgesics[ 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 27.Which drug has severe side effects in gastrointestinal tract 】 A.indomethacin B.acetaminophen C.naproxen D.celecoxib E.rofecoxib 28.The effects of aspirin do not include 】 A.reduction of fever B.pain relief C.decrease the PGs synthesis in inflamed tissues D.reduction of bleeding tendency E.impaired of protective mucus synthesis 29.True statements about codeine include that it 】 A.produces naloxone-reversible respiratory depression B.may cause hypotension as a result of histamine release C.has antitussive properties D.is partially biotransformed to morphine E.all description above are correct 30.Which drug below has high incidence rate of rhabdomyolysis 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.Vit E 31.Which drug below can acts on PPAR alfa 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam 5

5 A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 22.Chlorpromazine can be used to treat nausea and vomiting caused by many factors EXCEPT for 【 】 A.digoxin B.radiation C.pregnancy D.motion sickness E.morphine 23.The good candidate for treatment of asphyxia of newborn baby is 【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 24．The use of morphine is contraindicated in【 】 A.myocardial infarction B.acute pulmonary edema C.simple diarrhea D.kidney colic E.bronchial asthma 25.The major pharmacological mechanism of naloxone is【 】 A.exciting the μreceptor B.antagonizing theμreceptor C.exciting theαreceptor D.exciting theβreceptor E.blockage of M receptor 26.Which drug below dose not belong to narcotic analgesics【 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 27.Which drug has severe side effects in gastrointestinal tract 【 】 A.indomethacin B.acetaminophen C.naproxen D.celecoxib E.rofecoxib 28.The effects of aspirin do not include 【 】 A.reduction of fever B.pain relief C.decrease the PGs synthesis in inflamed tissues D.reduction of bleeding tendency E.impaired of protective mucus synthesis 29.True statements about codeine include that it 【 】 A.produces naloxone-reversible respiratory depression B.may cause hypotension as a result of histamine release C.has antitussive properties D.is partially biotransformed to morphine E.all description above are correct 30.Which drug below has high incidence rate of rhabdomyolysis 【 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.Vit E 31.Which drug below can acts on PPAR alfa 【 】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam

32.The mechanism of digoxin toxicity is A.enhancement of cardiac ribosome function in protein synthesis B.enhancement of muscarine endplate receptor function in the heart C.inhibition of acetylchol inesterase D.enhancement of adenylate cyclase E.inhibition of Na+,K+ATPase 33.Cardiac glycosides can not be used for treatment of 】 A.congestive heart failure B.atrial fibrillation C.atrial flutter D.paroxymal supraventricular tachycardia E.ventricular tachycardia 34.A major pharmacological mechanisms of Amrinone is inhibition of 【 】 A.HMG-CoA reductase B.ACE C.muscarinic R D.B,R E.PDE III 35.Which one of the following action can hydrochlorothiazide produce 【 】 A.hyperuricemia B.hyperkalemia C.hypocalcemia D.blood pressure increase E.hypoglycemia in diabetes patient 36.Correct statements about spironolactone is that 】 A.It is indicated in the presence of hyperkalemia B.It can not interfere with the functions of sex hormones C.It can not produce CNS side effects D.It interferes with aldosterone synthesis E.It can antagonize aldosterone receptor 37.Side effects associated with furosemide include 】 A.hyperuricemia B.metabolic alkalosis C.fluid and electrolyte imbalance D.hyponatremia E.all descriptions above are correct 38.Which of the following agents is not used for treatment of variant angina 【 】 A.nitroglycerin B.veraparmil C.propranolol D.isosorbide dinitrate E.isosorbide mononitrate 39.Which substance involves in the mechanism of antianginal function of nitroglycerin【 6

6 32.The mechanism of digoxin toxicity is【 】 A.enhancement of cardiac ribosome function in protein synthesis B.enhancement of muscarine endplate receptor function in the heart C.inhibition of acetylcholinesterase D.enhancement of adenylate cyclase E.inhibition of Na+, K+ ATPase 33.Cardiac glycosides can not be used for treatment of 【 】 A.congestive heart failure B.atrial fibrillation C.atrial flutter D.paroxymal supraventricular tachycardia E.ventricular tachycardia 34.A major pharmacological mechanisms of Amrinone is inhibition of 【 】 A.HMG-CoA reductase B.ACE C.muscarinic R D.β1 R E.PDE III 35.Which one of the following action can hydrochlorothiazide produce 【 】 A.hyperuricemia B.hyperkalemia C.hypocalcemia D.blood pressure increase E.hypoglycemia in diabetes patient 36.Correct statements about spironolactone is that 【 】 A.It is indicated in the presence of hyperkalemia B.It can not interfere with the functions of sex hormones C.It can not produce CNS side effects D.It interferes with aldosterone synthesis E.It can antagonize aldosterone receptor 37.Side effects associated with furosemide include【 】 A.hyperuricemia B.metabolic alkalosis C.fluid and electrolyte imbalance D.hyponatremia E.all descriptions above are correct 38.Which of the following agents is not used for treatment of variant angina 【 】 A.nitroglycerin B.veraparmil C.propranolol D.isosorbide dinitrate E.isosorbide mononitrate 39.Which substance involves in the mechanism of antianginal function of nitroglycerin【 】

A.carbon monoxide B.nitric oxide C.Y-GABA D.TXA2 E.substance P 40.The good candidate for treatment of hiccup is 】 A.lithium carbonate B.haloperidol C.norepinephrine D.atropine E.fluoxetine 41.Which statement is true about vitamin K 】 A.Vitamin K,and Ka do not need the help of bile salts for absorption B.Vitamin K,is synthesized by intestinal bacteria C.Vitamin K is required for the synthesis of clotting factors in the liver D.Deficiency of vitamin K in a normal diet is common. E.Vitamin K may be used to prevent urgent bleeding. 42.Which of the following may increase iron absorption[ 1 A.Vitamin CB.NaHCO,C.Tannic acid D.Phosphorus and calcium E.Tetracyclines 43.What drug can be used to treat bleeding caused by Urokinase 】 A.Vitamin K B.Protamine sulfate C.Aminocaproic acid D.Ferrous sulfate E.Folic acid 44.Megaloblastic anemia caused by dihydrofolate reductase inhibitor should use 【 】 A.VitBia B.Leucovorin C.Ferrous sulfate D.Iron dextran E.Folic acid 45.A long-acting glucocorticoid is 】 A.dexamethasone B.hydrocortisone C.cortisol D.methylprednisolone E.prednisone 46.Which of the fol lowing is not an action of glucocorticoids[ 】 A.Immunosuppressive B.Anti-inflammatory C.Increase of red blood cells D.Nervous system excitatio E.Increase of lymphocyte 47.Result of abrupt withdrawal of corticosteroid after treatment usually is 【 A.adrenal insufficiency B.hyperactivity of the adrenal cortex C.an adrenal cortex with decrease response to ACTH D.A and C E.all of the bove 48.Cortisol can produce following effects EXCEPT 7

7 A.carbon monoxide B.nitric oxide C.γ-GABA D.TXA2 E.substance P 40.The good candidate for treatment of hiccup is 【 】 A.lithium carbonate B.haloperidol C.norepinephrine D.atropine E.fluoxetine 41.Which statement is true about vitamin K 【 】 A.Vitamin K1 and K2 do not need the help of bile salts for absorption B.Vitamin K3 is synthesized by intestinal bacteria C.Vitamin K is required for the synthesis of clotting factors in the liver D.Deficiency of vitamin K in a normal diet is common. E.Vitamin K may be used to prevent urgent bleeding. 42.Which of the following may increase iron absorption 【 】 A.Vitamin C B.NaHCO3 C.Tannic acid D.Phosphorus and calcium E.Tetracyclines 43.What drug can be used to treat bleeding caused by Urokinase 【 】 A.Vitamin K B.Protamine sulfate C.Aminocaproic acid D.Ferrous sulfate E.Folic acid 44.Megaloblastic anemia caused by dihydrofolate reductase inhibitor should use 【 】 A.VitB12 B.Leucovorin C.Ferrous sulfate D.Iron dextran E.Folic acid 45.A long-acting glucocorticoid is 【 】 A.dexamethasone B.hydrocortisone C.cortisol D.methylprednisolone E.prednisone 46.Which of the following is not an action of glucocorticoids 【 】 A.Immunosuppressive B.Anti-inflammatory C.Increase of red blood cells D.Nervous system excitatio E.Increase of lymphocyte 47.Result of abrupt withdrawal of corticosteroid after treatment usually is 【 】 A.adrenal insufficiency B.hyperactivity of the adrenal cortex C.an adrenal cortex with decrease response to ACTH D. A and C E.all of the bove 48.Cortisol can produce following effects EXCEPT 【 】

A.Increasing storage of glycogen in the liver B.Negative nitrogen balance C.Redistribution of body fat D.Decreasing serum glucose levels E.Na'and water retention 49.Aluminum and calcium salts inhibit the intestinal absorption of which of the following agents？【 】 A.Isoniazid B.Chloramphenicol C.Penicillin V D.Erythromycin E.Tetracycline 2.In the treatment of infections caused by Pseudomonas aeruginosa.the antimicrobial agent that has proven to be effective is 】 A.penicillinG B.carbenicillin C.oxacillin D.erythromycin E.tetracycline 51.Cephalothin,a first generation cephalosporin.has antibacterial activity based on a mechanism of action that includes 】 A.interference with cross linking of peptidoglycan strands B.inhibition of protein synthesis C.functional alteration of 30 S ribosomal synthesis D.inhibition of nucleic acid synthesis E.competitive antagonism of pteroylglutamic acid synthesis 52.All the following penicillins are resistant to penicillinase EXCEPT 【 1 A.oxacillin B.cloxacillin C.amoxycillin D.nafcillin E.dicloxacillin 53.5.True statement about T3 or T4 include all the fol lowing EXCEPT 【 A.T3 readily penetrates cellular membrane B.The daily releasing amount of T4 is much more than that of T3 C.The plasma protein binding rate of T4 is much more than that of T3 D.They all bind to receptors in nucleus E.The T1/2 of T4 is shorter than that of T3. 8

8 A.Increasing storage of glycogen in the liver B.Negative nitrogen balance C.Redistribution of body fat D.Decreasing serum glucose levels E.Na+ and water retention 49.Aluminum and calcium salts inhibit the intestinal absorption of which of the following agents? 【 】 A．Isoniazid B. Chloramphenicol C.Penicillin V D.Erythromycin E.Tetracycline 2.In the treatment of infections caused by Pseudomonas aeruginosa, the antimicrobial agent that has proven to be effective is 【 】 A.penicillin G B.carbenicillin C.oxacillin D.erythromycin E.tetracycline 51.Cephalothin, a first generation cephalosporin, has antibacterial activity based on a mechanism of action that includes 【 】 A.interference with cross linking of peptidoglycan strands B. inhibition of protein synthesis C. functional alteration of 30 S ribosomal synthesis D. inhibition of nucleic acid synthesis E. competitive antagonism of pteroylglutamic acid synthesis 52.All the following penicillins are resistant to penicillinase EXCEPT 【 】 A.oxacillin B.cloxacillin C.amoxycillin D.nafcillin E.dicloxacillin 53.5.True statement about T3 or T4 include all the following EXCEPT 【 】 A.T3 readily penetrates cellular membrane B.The daily releasing amount of T4 is much more than that of T3 C.The plasma protein binding rate of T4 is much more than that of T3 D.They all bind to receptors in nucleus E.The T1/2 of T4 is shorter than that of T3

54.The action of propylthiouracil is thought to involve which of the following mechanisms？【 】 A.Blocking the enzymatic oxidation of iodide B.Preventing the uptake of iodide C.Preventing the synthesis of thyroglobul in D. Blocking the release of thyroxine E.Inhibiting the release of thyroid stimulating hormone 55.Which of the following drug is agonist of PPARy receptor? A.Metformin B.Phenformin C.Rosiglitazone D.GI imepiride E.Acarbose 56.8.Which of the fol lowing drug is suitable for treatment of diabetes with obesity?【 】 A.Metformin B.insulin C.Rosiglitazone D.GIimepiride E.Acarbose 57.All of the following antimicrobials inhibit bacterial protein synthesis EXCEPT【 】 A.Erythromycin.B.Cefazolin C.Amikacin D.Tetracycline E.Clindamycin 58.A valid clinical use of clindamycin is 】 A.Treatment of gonorrhea B.Severe infection due to Bacteroides spp or anaerobic C.Respiratory infection due to Mycoplasma spp.D.Rickettsial infections E.Clostridium difficile gastrointestinal infection 59.A drug that decreases gastric acid secretion and has antiandrogenic effects. 【 】 A.Diphenhydramine B.Ergotamine tartrate C.Terfenadine D.Cimetidine E.Ranitidine 60.A drug which causes the "gray syndrome"in the newborn and hematologic

9 54.The action of propylthiouracil is thought to involve which of the following mechanisms? 【 】 A.Blocking the enzymatic oxidation of iodide B.Preventing the uptake of iodide C.Preventing the synthesis of thyroglobulin D. Blocking the release of thyroxine E.Inhibiting the release of thyroid stimulating hormone 55.Which of the following drug is agonist of PPAR receptor? 【 】 A.Metformin B.Phenformin C.Rosiglitazone D.Glimepiride E.Acarbose 56.8. Which of the following drug is suitable for treatment of diabetes with obesity? 【 】 A. Metformin B. insulin C. Rosiglitazone D. Glimepiride E. Acarbose 57.All of the following antimicrobials inhibit bacterial protein synthesis EXCEPT 【 】 A.Erythromycin. B.Cefazolin C.Amikacin D.Tetracycline E.Clindamycin 58.A valid clinical use of clindamycin is 【 】 A.Treatment of gonorrhea B.Severe infection due to Bacteroides spp or anaerobic C.Respiratory infection due to Mycoplasma spp. D.Rickettsial infections E.Clostridium difficile gastrointestinal infection 59.A drug that decreases gastric acid secretion and has antiandrogenic effects. 【 】 A.Diphenhydramine B.Ergotamine tartrate C.Terfenadine D.Cimetidine E.Ranitidine 60.A drug which causes the "gray syndrome" in the newborn and hematologic

reactions【 】 A.Amoxiciilin. B.Cefazolin C.Erythromycin D.Chloramphenicol E.Streptomycin 61.Kernicterus in newborn or premature infants treated with sulfonamides is due to【 】 A.Enhanced synthesis of bilirubin B.Displacement of bound bilirubin from albumin C.Inlhibition of bilimbin degradation D.Inhibition of urinary excretion of bilirubin E.Deposition of crystalline aggregates in the kidneys 62.The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is 】 A.Primaquine B.mefloquine C.Quinine D.Chloroquine E.Artemisinin 63.Antimetabol ic drugs include all the fol lowing EXCEPT 1 A.cyclophosphamide B.cytarabine C.5-fluorouracil D.6-mercaptopurine E.methotrexate 64.Which of the following statements about the neurotoxicity of isoniazid is true?【 】 A.It can be prevented by streptomycin B.It can be treated with vitamin B1 C.It is responsive to pyridoxine therapy D.It only occurs in toxic dose level E.It interferes with the therapeutic effect 65.Candidiasis of the vagina.gastrointestinal tract,and oral cavity is treated primarily by which of the following drugs? 1 A.Nystatin B.Miconazole C.Rifampin D.Griseofulvin E.lodide 10

10 reactions 【 】 A.Amoxiciilin. B.Cefazolin C.Erythromycin D.Chloramphenicol E.Streptomycin 61.Kernicterus in newborn or premature infants treated with sulfonamides is due to 【 】 A.Enhanced synthesis of bilirubin B.Displacement of bound bilirubin from albumin C.Inlhibition of bilimbin degradation D.Inhibition of urinary excretion of bilirubin E.Deposition of crystalline aggregates in the kidneys 62.The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is 【 】 A.Primaquine B.mefloquine C.Quinine D.Chloroquine E.Artemisinin 63.Antimetabolic drugs include all the following EXCEPT 【 】 A.cyclophosphamide B.cytarabine C.5-fluorouracil D.6-mercaptopurine E.methotrexate 64.Which of the following statements about the neurotoxicity of isoniazid is true? 【 】 A.It can be prevented by streptomycin B.It can be treated with vitamin B1 C.It is responsive to pyridoxine therapy D.It only occurs in toxic dose level E.It interferes with the therapeutic effect 65.Candidiasis of the vagina, gastrointestinal tract, and oral cavity is treated primarily by which of the following drugs? 【 】 A.Nystatin B.Miconazole C.Rifampin D.Griseofulvin E.Iodide