《药理学》课程教学资源（试卷习题）examination paper A（含答案）

Examination paper of (pharmacology)for the the second term of 2005-2006 academic year of Chongqing medical university Mode of the examination:closed,Time for the examination:90 minutes The grade and the subject which the examination paper be applied grade 2006. medical science Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey "The role of the examination room of chongqingmedical university"rigoroursly.The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out "The rule of the task and responsibility in the examinations "rigoroursly."The additional rule of the further specification of the task in the examinations and ensure the order of the examination room by carry out "The responsibility of the supervisior of chongqing medical university"seriously. Question number Ill IV Total marks Score Sign by appraiser I.Type A:(DIRECTIONS:Each question below contains five suggested answers. Choose the best one response to each question.The marks of each question is 1,totally 70 marks): 1.Drugs may be released slowly from various drug reservoirs after absorbed and stored in the body.The body reservoir that holds the largest amount of the barbiturate thiopental is【A】 A.fat B.lung C.liver D.muscle E.serum albumin 2.The most common route of excretion for drugs is B

1 Examination paper of《pharmacology》for the the second term of 2005—2006 academic year of Chongqing medical university Mode of the examination：closed， Time for the examination：90 minutes The grade and the subject which the examination paper be applied ： grade 2006， medical science. Guides of the examination Students of chongqing medical university attend any examonation that organizied by the university must obey “The role of the examination room of chongqingmedical university”rigoroursly. The the students who violate the discipline and cheating in the examination will be punished rigorously by university according to the related rule. Any supervisior of the examinations must carry out “The rule of the task and responsibility in the examinations ”rigoroursly,“The additional rule of the further specification of the task in the examinations ”and ensure the order of the examination room by carry out “ The responsibility of the supervisior of chongqing medical university”seriously. Question number Ⅰ Ⅱ Ⅲ Ⅳ Total marks Score Sign by appraiser I.Type A：（DIRECTIONS: Each question below contains five suggested answers. Choose the best one response to each question. The marks of each question is 1，totally 70 marks）: 1．Drugs may be released slowly from various drug reservoirs after absorbed and stored in the body. The body reservoir that holds the largest amount of the barbiturate thiopental is 【 A 】 A．fat B．lung C．liver D．muscle E．serum albumin 2．The most common route of excretion for drugs is 【 B 】 College or department class and grade name student number

A.Biliary tract B.Kidneys C.Lungs D.Feces E.Milk 3.If a drug has an elimination half time (tin)of 24 hours and 10 mg is administered intravenously once daily.how many days are needed at least for the drug to arrive at Css？【 C】 A.1 day B.3 days C.5 days D.7 days E.9 days 4.The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is E 】 A.the peak blood concentration B.the time that is needed for drug to arrive at peak blood concentration after administration C.volume of distribution D.the first-order rate constant E.the area under the blood concentration-time curve 5.After given orally.which of fol lowing drugs is the most easily absorbed from the bowels(suppose the value of pH in the bowel is 6.0)?A 】 A.acetaminophen,weak acid.pKa 9.5 B.aspirin,weak acid,pKa 3.5 C.phenobarbital,weak acid.pKa 8.1 D.atropine.weak base,pKa 9.7 E.clonidine.weak base.pKa 8.3 6.The characteristics of hepatic drug enzymes include the fol lowing items EXCEPT【A 】 A.The enzumes have high specificity B.Large individual difference of the enzymes exist C.The activities of enzumes is variable D.The activities of enzymes can be induced or inhibited by some drugs E.The enzymes catalyze the oxidation and reduction of drugs 7.Which of the following parameters is used to evaluate the safety of drugs 【C 】 A.EDso B.LDao C.TI D.efficacy E.potency 8.Gingival hyperplasia is a complication of long-term antiepileptic treatment with【D 】 2

2 A．Biliary tract B．Kidneys C．Lungs D．Feces E．Milk 3．If a drug has an elimination half time (t1/2) of 24 hours and 10 mg is administered intravenously once daily, how many days are needed at least for the drug to arrive at Css? 【 C 】 A．1 day B．3 days C． 5 days D．7 days E．9 days 4．The pharmacokinetic value that most reliably reflects the amount of drug absorbed from the sites in which drug is given is 【 E 】 A．the peak blood concentration B．the time that is needed for drug to arrive at peak blood concentration after administration C．volume of distribution D．the first-order rate constant E．the area under the blood concentration-time curve 5．After given orally, which of following drugs is the most easily absorbed from the bowels (suppose the value of pH in the bowel is 6.0)? 【 A 】 A．acetaminophen, weak acid, pKa 9.5 B．aspirin, weak acid, pKa 3.5 C．phenobarbital, weak acid, pKa 8.1 D．atropine, weak base, pKa 9.7 E．clonidine, weak base, pKa 8.3 6．The characteristics of hepatic drug enzymes include the following items EXCEPT 【 A 】 A．The enzumes have high specificity B．Large individual difference of the enzymes exist C．The activities of enzumes is variable D．The activities of enzymes can be induced or inhibited by some drugs E．The enzymes catalyze the oxidation and reduction of drugs 7．Which of the following parameters is used to evaluate the safety of drugs 【 C 】 A．ED50 B．LD50 C．TI D．efficacy E．potency 8．Gingival hyperplasia is a complication of long-term antiepileptic treatment with 【 D 】

A.phenobarbital B.primidone C.diazepam D.phenytoin E.valproic acid 9.Absence (petit mal)seizure is best treated with which of the fol lowing drugs? 【 E】 A.chlorpromazine B.phenytoin C.verapamil D.cabamazipine E.ethosuximide 10.The preferred treatment of status epilepticus is intravenous administration of which of the fol lowing drugs? B】 A.chlorpromazine B.diazepam C.succinylcholine D.ethosuximide E.phenytoin 11.The drug of choice for the treatment of anaphylactic shock is B】 A.histamine B.epinephrine (adrenaline)C.norepinephr ine(noradrenaline) D.isoproterenol (isoprenaline)E.diphenhydramine 12.Functionally.a patient with myasthenia gravis resembles a person who is being treated with low doses of【E】 A.atropine B.propranolol C.methacholine D.muscar ine E.tubocurarine 13.All the drugs belong to the catecholamine EXCEPT D 】 A.adrenaline B.dopamine C.noradrenaline D.ephedrine E.isoprenaline 14.All the following structures respond to B-adrenergic receptor stimulation EXCEPT【B 】 A.the ciliary muscle of the iris B.the radial muscle of the iris C.bronchial muscle D.the atrio ventrlcular node E.the sinoatrial node 15.The adrenal medulla secretes epinephrine in response to administration of 【E 】 A.atropine B.tubecurarine C.succinylchol ine D.methyldopa E.nicotine 16.Which of fol lowing mechanisms is responsible for elimination of endogenous noradrenaline?【D A.the enzyme called COM B.the enzyme called MAO C.the uptake by peripheral tissues D.the uptake by nerve endings

3 A．phenobarbital B．primidone C．diazepam D．phenytoin E．valproic acid 9．Absence (petit mal) seizure is best treated with which of the following drugs? 【 E 】 A．chlorpromazine B．phenytoin C．verapamil D．cabamazipine E．ethosuximide 10．The preferred treatment of status epilepticus is intravenous administration of which of the following drugs? 【 B 】 A．chlorpromazine B．diazepam C．succinylcholine D．ethosuximide E．phenytoin 11 ． The drug of choice for the treatment of anaphylactic shock is 【 B 】 A．histamine B．epinephrine (adrenaline) C．norepinephrine (noradrenaline) D．isoproterenol (isoprenaline) E．diphenhydramine 12．Functionally, a patient with myasthenia gravis resembles a person who is being treated with low doses of 【 E 】 A．atropine B．propranolol C．methacholine D．muscarine E．tubocurarine 13．All the drugs belong to the catecholamine EXCEPT 【 D 】 A．adrenaline B．dopamine C．noradrenaline D．ephedrine E．isoprenaline 14．All the following structures respond to -adrenergic receptor stimulation EXCEPT 【 B 】 A．the ciliary muscle of the iris B．the radial muscle of the iris C．bronchial muscle D．the atrio ventrlcular node E．the sinoatrial node 15．The adrenal medulla secretes epinephrine in response to administration of 【 E 】 A．atropine B．tubecurarine C．succinylcholine D．methyldopa E．nicotine 16．Which of following mechanisms is responsible for elimination of endogenous noradrenaline? 【 D 】 A．the enzyme called COM B．the enzyme called MAO C．the uptake by peripheral tissues D．the uptake by nerve endings

E.the excretion by kidneys 17.Which of following drugs is a pure acetylcholinesterase inhibitor? 【 A 】 A.physostigmine B.pilocarpine C.neostigmine D.muscarine E.acetylcholine 18.A predictably dangerous side effect of propranolol,is C A.inducting hypertensio B.inducting cardiac arrhythmia C.inducting asthmatic attacks D.inducting elevation of sugar level in blood E.inducting retention of sodium and water in body 19.Which of fol lowing symptoms still exists after large doses of atropine are used to treat the patients with organic phosphate intoxication? 【D A.excessive secretion salivation B.gastrointenstinal spasm C.bronchospam D.switching skeletal muscles E.miosis 20.Which of following drugs is suitable for patients with hypertensive crisis? 】 A.clonidine B.prazosin C.sodiumnitroprussid D.nifedipine E.hydrochlorothiazide 21.An important action of imipramine is the inhibition of B A.norepinephrine release B.norepinephr ine uptake C.acetylcholine release D.dopamine uptake E.serotonin synthesis 22.Which drug below dose not belong to narcotic analgesics B 】 A.codein B.pentazocine C.methadone D.meperidine E.morphine 23.The good candidate for treatment of mania is A 】 A.lithium carbonate B.clozapine C.norepinephrine D.atropine E.fluoxetine 24.Morphine dose not have【C】 A.sedation B.cough suppression C.inhibition of vomiting D.stimulation of intestinal smooth muscle E.respiratory suppression 25.The analgesic mechanism of meperidine is A】 4

4 E．the excretion by kidneys 17 ． Which of following drugs is a pure acetylcholinesterase inhibitor? 【 A 】 A．physostigmine B．pilocarpine C．neostigmine D．muscarine E．acetylcholine 18．A predictably dangerous side effect of propranolol, is 【 C 】 A．inducting hypertensio B．inducting cardiac arrhythmia C．inducting asthmatic attacks D．inducting elevation of sugar level in blood E．inducting retention of sodium and water in body 19．Which of following symptoms still exists after large doses of atropine are used to treat the patients with organic phosphate intoxication? 【 D 】 A．excessive secretion salivation B．gastrointenstinal spasm C．bronchospam D．switching skeletal muscles E．miosis 20．Which of following drugs is suitable for patients with hypertensive crisis? 【 C 】 A．clonidine B．prazosin C．sodiumnitroprussid D．nifedipine E．hydrochlorothiazide 21．An important action of imipramine is the inhibition of【 B 】 A．norepinephrine release B．norepinephrine uptake C．acetylcholine release D．dopamine uptake E．serotonin synthesis 22．Which drug below dose not belong to narcotic analgesics【 B 】 A．codein B．pentazocine C．methadone D．meperidine E．morphine 23．The good candidate for treatment of mania is 【 A 】 A．lithium carbonate B．clozapine C．norepinephrine D． atropine E．fluoxetine 24．Morphine dose not have【 C 】 A．sedation B．cough suppression C．inhibition of vomiting D．stimulation of intestinal smooth muscle E．respiratory suppression 25．The analgesic mechanism of meperidine is【 A 】

A.exciting the Hreceptor B.antagonizing the u receptor C.exciting the a receptor D.exciting the B receptor E.blockage of M receptor 26.The good candidate for treatment of morphine overdose toxicity is 【E 】 A.methadone B.meperidine C.propranolol D.codein E.naloxone 27.The drug which lacks anti-inflammatory action is B 】 A.aspirin B.acetaminophen C.naproxen D.celecoxib E.indomethacin 28.Which drug is high selective inhibitor of COX2[D 】 A.aspirin B.acetaminophen C.naproxen D.celecoxib E.indomethacin 29.Which substance involves in the mechanism of platelet aggregation inhibition of aspirin D】 A.PGE2 B.PGF2.C.PGI2 D.TXA2 E.substance P 30.The good candidate for treatment of respiratory failure caused by carbon monoxide is【 】 A.Nikethamide B.caffeine C.lobeline D.Amphetamine E.piracetam 31.Which drug below can inhibit cholesterol synthesis by HMG-CoA reductase inhibition【 D】 A.clofibrate B.nicotinic acid C.colestipol D.lovastatin E.piracetam 32.Which drug below is not useful for treatment of congestive heart failure C】 A.cardiac glycosides B.ACEI C.muscarinic agonist D.B,R antagonist E.PDE III inhibitor 33.Which drug below can agitate the toxicity caused by digoxin B A.potassium supply B.calcium supply C.antidigoxin antibody D.atropine E.phenytoin 34.A major pharmacological mechanisms of Amrinone is inhibition of 【E 】 A.HMG-CoA reductase B.ACE C.muscarinic R D.B,R E.PDE III 35.Amajor pharmacological mechanisms of cardiac glycosides is[E A.enhancement of cardiac ribosome function in protein synthesis 5

5 A．exciting the μreceptor B．antagonizing theμreceptor C．exciting theαreceptor D．exciting theβreceptor E．blockage of M receptor 26 ． The good candidate for treatment of morphine overdose toxicity is 【 E 】 A．methadone B．meperidine C．propranolol D．codein E．naloxone 27．The drug which lacks anti-inflammatory action is 【 B 】 A．aspirin B．acetaminophen C．naproxen D．celecoxib E．indomethacin 28．Which drug is high selective inhibitor of COX2【 D 】 A．aspirin B．acetaminophen C．naproxen D．celecoxib E．indomethacin 29 ． Which substance involves in the mechanism of platelet aggregation inhibition of aspirin 【 D 】 A．PGE2 B．PGF2α C．PGI2 D．TXA2 E．substance P 30．The good candidate for treatment of respiratory failure caused by carbon monoxide is 【 C 】 A．Nikethamide B．caffeine C．lobeline D．Amphetamine E．piracetam 31．Which drug below can inhibit cholesterol synthesis by HMG-CoA reductase inhibition 【 D 】 A．clofibrate B．nicotinic acid C．colestipol D．lovastatin E．piracetam 32．Which drug below is not useful for treatment of congestive heart failure 【 C 】 A．cardiac glycosides B．ACEI C．muscarinic agonist D．β1 R antagonist E．PDE III inhibitor 33．Which drug below can agitate the toxicity caused by digoxin 【 B 】 A ． potassium supply B ． calcium supply C ． antidigoxin antibody D． atropine E．phenytoin 34 ． A major pharmacological mechanisms of Amrinone is inhibition of 【 E 】 A．HMG-CoA reductase B．ACE C．muscarinic R D．β1 R E．PDE III 35．A major pharmacological mechanisms of cardiac glycosides is【 E 】 A．enhancement of cardiac ribosome function in protein synthesis

B.enhancement of muscarine endplate receptor function in the heart C.inhibition of acetylcholinesterase D.enhancement of adenylate cyclase E.inhibition of Na+.K+ATPase 36.in a adrenal ectomized patient,which one of the following agents has no diuretic effect【D 】 A.triamterene B.hydrochlorothiazide C.furosemide D.Spironolactone E.acetazolamide 37.Diuretics that function primarily in ascending limb of Henle loop include 【D 】 A.triamterene B.chlorothiazide C.spironolactone D.furosemide E.Acetazolamide 38.Ototoxicity is a rare but serious manifestation of B 】 A.mannitol B.ethacrynic acid C.spironolactone D.triamterene E.Acetazolamide 39.Which of the fol lowing agents is not used for treatment of variant angina 【 】 A.nitroglycerin B.veraparmil C.propranolol D.isosorbide dinitrate E.isosorbide mononitrate 40.Which substance involves in the mechanism of antianginal function of nitroglycerin【 B】 A.carbon monoxide B.nitric oxide C.Y-GABA D.TXA,E.substance P 41.Which of the following is true about the use of anticoagulant drugs 【 E 】 A.Heparin can be administered by oral. B.Warfarin has quick onset and long duration C.Warfarin is agonist of vitamin K. D.Warfarin is effective both in vivo and in vitro. E.Heparin enhances inactivation of clotting factors. 42.What drug can antagonist bleeding caused by heparin B A.Vitamin K B.Protamine sulfate C.Aminocaproic acid 6

6 B．enhancement of muscarine endplate receptor function in the heart C．inhibition of acetylcholinesterase D. enhancement of adenylate cyclase E．inhibition of Na+, K+ ATPase 36．in a adrenal ectomized patient, which one of the following agents has no diuretic effect【 D 】 A．triamterene B．hydrochlorothiazide C．furosemide D．Spironolactone E．acetazolamide 37．Diuretics that function primarily in ascending limb of Henle loop include 【 D 】 A．triamterene B．chlorothiazide C．spironolactone D．furosemide E．Acetazolamide 38．Ototoxicity is a rare but serious manifestation of【 B 】 A．mannitol B．ethacrynic acid C．spironolactone D．triamterene E．Acetazolamide 39．Which of the following agents is not used for treatment of variant angina 【 C 】 A．nitroglycerin B．veraparmil C．propranolol D．isosorbide dinitrate E．isosorbide mononitrate 40．Which substance involves in the mechanism of antianginal function of nitroglycerin【 B 】 A．carbon monoxide B．nitric oxide C．γ-GABA D．TXA2 E．substance P 41．Which of the following is true about the use of anticoagulant drugs 【 E 】 A．Heparin can be administered by oral. B．Warfarin has quick onset and long duration. C．Warfarin is agonist of vitamin K. D. Warfarin is effective both in vivo and in vitro． E．Heparin enhances inactivation of clotting factors. 42．What drug can antagonist bleeding caused by heparin 【 B 】 A．Vitamin K B．Protamine sulfate C．Aminocaproic acid

D.Tranexamic acid E.Folic acid 43.Which statement is false about iron absorption C A.VitaminC increase iron absorption B.Diluted HCI increase iron absorption C.Tannic acid increase iron absorption D.Phosphorus and calcium inhibit iron absorption E.Tetracyclines inhibit iron absorption 44.To treat pernicious anemia should choose B 】 A.Oral administration of VitBnz B.Injection administration of VitB,2 C.Oral administration of ferrous sulfate D.Injection administration of iron dextran E.Oral administration of folic acid 45.Which of the following have the greatest anti-inflammatory potency C】 A.Cortisone B.Hydrocortisone C.Dexamethasone D.Prednisone E.Prednisolone 46.Result of abrupt withdrawal of corticosteroid after treatment usually is 【 A 】 A.Adrenal insufficiency B.Hyperactivity of the adrenal cortex C.HypertensionD.Peptic ulcer E.Fat redistribution 47.Glucocorticoids have following effect on blood components EXCEPT A】 A.Increasing lymphocytes B.Increasing red blood cells C.Increasing platelets D.Increasing neutrophils E.Increasing hemoglobin 48.Glucocorticoids can be used to treat the following diseases EXCEPT 【 D 】 A.Autoimmune diseases B.Aplastic anemia C.Lymphocytic leukaemias D.Osteoporosis E.Chronic bronchial asthma 49.Clavulanic acid,a new type of B-lactam antibiotic.is important because it【D】 7

7 D．Tranexamic acid E．Folic acid 43．Which statement is false about iron absorption 【 C 】 A．Vitamin C increase iron absorption B．Diluted HCl increase iron absorption C．Tannic acid increase iron absorption D．Phosphorus and calcium inhibit iron absorption E．Tetracyclines inhibit iron absorption 44．To treat pernicious anemia should choose 【 B 】 A．Oral administration of VitB12 B．Injection administration of VitB12 C．Oral administration of ferrous sulfate D．Injection administration of iron dextran E．Oral administration of folic acid 45 ． Which of the following have the greatest anti-inflammatory potency 【 C 】 A．Cortisone B．Hydrocortisone C．Dexamethasone D．Prednisone E．Prednisolone 46．Result of abrupt withdrawal of corticosteroid after treatment usually is 【 A 】 A．Adrenal insufficiency B．Hyperactivity of the adrenal cortex C．HypertensionD. Peptic ulcer E．Fat redistribution 47 ． Glucocorticoids have following effect on blood components EXCEPT 【 A 】 A．Increasing lymphocytes B．Increasing red blood cells C．Increasing platelets D．Increasing neutrophils E．Increasing hemoglobin 48 ． Glucocorticoids can be used to treat the following diseases EXCEPT 【 D 】 A．Autoimmune diseases B．Aplastic anemia C．Lymphocytic leukaemias D．Osteoporosis E．Chronic bronchial asthma 49．Clavulanic acid, a new type of ß-lactam antibiotic, is important because it【 D 】

A.Easily penetrates gram-negative microorganisms B.Is specific for gram-positive microorganisms C.Is a potent inhibitor of cell wall transpeptidase D.Inactivates bacterial B-lactamases E.Has a spectrum of activity similar to penicillin G 50.The therapy of choice in the treatment of meningococcal meningitis is 【c A.erythromycin,intravenously B.amphotericin B,intravenously C.penicillin G,intravenously D.streptomyc in,intramuscularly E.tetracycline.intravenously 51.For the treatment of a patient with Legionella pneumonia,the drug of 【c 】 A.penicillinG B.chloraphenicol C.erythromycin D.SMZ E.lincomyin 52.A possible treament for Mycoplasma pneumoniae would be B 】 A.penicillinG B.tetracycline C.vancomycin D.gentamycin E.bacitracin 53.Chloramphenicol is the drug of choice for the treatment of A A.typhoid fever B.gonorrhea C.S.aureus infections D.anthrax E.gas gangrene 54.True statement about T3 or T4 include all the following EXCEPT 【E 】 A.T3 readily penetrates cellular membrane B.The daily releasing amount of T4 is much more than that of T3 C.The plasma protein binding rate of T4 is much more than that of T3 D.They all bind to receptors in nucleus E.The T1/2 of T4 is shorter than that of T3 55.The action of propylthiouracil is thought to involve which of the following mechanisms'？【 A A.Blocking the enzymatic oxidation of iodide 8

8 A．Easily penetrates gram-negative microorganisms B．Is specific for gram-positive microorganisms C．Is a potent inhibitor of cell wall transpeptidase D．Inactivates bacterial ß-lactamases E．Has a spectrum of activity similar to penicillin G 50．The therapy of choice in the treatment of meningococcal meningitis is 【 C 】 A ． erythromycin, intravenously B ． amphotericin B, intravenously C ． penicillin G, intravenously D ． streptomycin, intramuscularly E．tetracycline, intravenously 51．For the treatment of a patient with Legionella pneumonia, the drug of 【 C 】 A．penicillin G B．chloraphenicol C．erythromycin D．SMZ E．lincomyin 52．A possible treament for Mycoplasma pneumoniae would be【 B 】 A．penicillin G B．tetracycline C．vancomycin D．gentamycin E．bacitracin 53．Chloramphenicol is the drug of choice for the treatment of【 A 】 A．typhoid fever B．gonorrhea C．S. aureus infections D．anthrax E．gas gangrene 54 ． True statement about T3 or T4 include all the following EXCEPT 【 E 】 A．T3 readily penetrates cellular membrane B．The daily releasing amount of T4 is much more than that of T3 C．The plasma protein binding rate of T4 is much more than that of T3 D．They all bind to receptors in nucleus E．The T1/2 of T4 is shorter than that of T3 55．The action of propylthiouracil is thought to involve which of the following mechanisms? 【 A 】 A．Blocking the enzymatic oxidation of iodide

B.Preventing the uptake of iodide C.Preventing the synthesis of thyroglobul in D.Blocking the release of thyroxine E.Inhibiting the release of thyroid stimulating hormone 56.Which of the fol lowing drug has a hypoglucemic action through stimulating release of insulin?【 D 】 A.Metformin B.Phenformin C.Rosiglitazone D.GIimepiride E.Acarbose 57.Appropriate initial therapy for severe ketoacidosis C 1 A.Oral tolbutamide B.Subcutaneous ultralente insulin C.Intravenous crystalline insulin D.Intramuscular glucagon E.Oral hypertonic (50%)glucose 58.Plasmid-mediated bacterial resistance to this drug group involves synthesis of transferase enzymes that inactivate by addition of acetyl or other groups.【C A.Macrolides B.Tetracyclines C.Aminoglycosides D.Penicillins E.Sulfonamides 59.A drug active against methicillin-resistant staphylococcal strains is 【D 】 A.Gentamicin B.Cephalothin C.Erythromycin. D.Vancomycin E.Tetracycline 60.A drug that has significant action against motion sickness.[A A.Diphenhydramine B.Ergotamine tartrate C.Terfenadine D.Cimetidine E.Ranitidine 61.A 32-year-old cancer patient,who has smoked two packs of cigarettes a day for 10 years.presents a decreased pulmonary function test.Physical examination and chest x-rays suggest preexisting pulmonary disease.All the following drugs may be prescribed EXCEPT C 】 A.Vinblastine B.Doxorubicin (Adriamycin)C.Busulfan

9 B．Preventing the uptake of iodide C．Preventing the synthesis of thyroglobulin D．Blocking the release of thyroxine E．Inhibiting the release of thyroid stimulating hormone 56．Which of the following drug has a hypoglucemic action through stimulating release of insulin? 【 D 】 A．Metformin B．Phenformin C．Rosiglitazone D．Glimepiride E．Acarbose 57．Appropriate initial therapy for severe ketoacidosis 【 C 】 A．Oral tolbutamide B．Subcutaneous ultralente insulin C．Intravenous crystalline insulin D．Intramuscular glucagon E．Oral hypertonic (50%) glucose 58．Plasmid-mediated bacterial resistance to this drug group involves synthesis of transferase enzymes that inactivate by addition of acetyl or other groups．【 C 】 A．Macrolides B．Tetracyclines C．Aminoglycosides D．Penicillins E．Sulfonamides 59．A drug active against methicillin-resistant staphylococcal strains is 【 D 】 A．Gentamicin B．Cephalothin C．Erythromycin. D．Vancomycin E．Tetracycline 60．A drug that has significant action against motion sickness．【 A 】 A ． Diphenhydramine B ． Ergotamine tartrate C ． Terfenadine D．Cimetidine E． Ranitidine 61．A 32-year-old cancer patient, who has smoked two packs of cigarettes a day for 10 years, presents a decreased pulmonary function test. Physical examination and chest x-rays suggest preexisting pulmonary disease. All the following drugs may be prescribed EXCEPT【 C 】 A ．Vinblastine B．Doxorubicin (Adriamycin) C．Busulfan

D.Cyclophosphamide E.Cisplatin 62.The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is A A.Primaquine B.mefloquine C.Quinine D.Chloroquine E.Artemisinin 63.Ethambutol is administered concurrently with other antitubercular drugs in the treatment of tuberculosis in order to C I A.reduce the pain of injection B.facilitate penetration of the blood brain barrier C.retard the development of organism resistance D.delay excretion of other antitubercular drugs by the kidney E.retard absorption after intramuscular injection 64.The drug used both in the treatment of active tuberculosis and most commonly in the chemoprophylaxis of tuberculosis is D 】 A.ethambutol B.cycloserine C.streptomycin D.isoniazid E.p-aminosalicylic acid 65.Candidiasis of the vagina.gastrointestinal tract.and oral cavity is treated primarily by which of the following drugs?A 】 A.Nystatin B.Miconazole C.Rifampin D.Griseofulvin E.lodide 66.An inhibitor of DNA-dependent RNA polymerase.useful in tuberculosis,is 【c】 A.Isoniazid.B.Streptomycin.C.Rifampin.D.Ethambutol.E.Ethionamide. 67.All of the following drugs have clinically useful activity against Candida albicans EXCEPT【C 】 A.Nystatin. B.Ketoconazole. C.Griseofuivin. D.AmphotericinB.E.Flucytosine. 68.This anticancer drug with specificity for the S phase of the cell cycle is activated by kinases to form an inhibitor of DNA polymerase.E 】 10

10 D．Cyclophosphamide E．Cisplatin 62．The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is【 A 】 A．Primaquine B．mefloquine C．Quinine D．Chloroquine E．Artemisinin 63．Ethambutol is administered concurrently with other antitubercular drugs in the treatment of tuberculosis in order to【 C 】 A．reduce the pain of injection B．facilitate penetration of the blood brain barrier C．retard the development of organism resistance D．delay excretion of other antitubercular drugs by the kidney E．retard absorption after intramuscular injection 64．The drug used both in the treatment of active tuberculosis and most commonly in the chemoprophylaxis of tuberculosis is【 D 】 A．ethambutol B．cycloserine C．streptomycin D．isoniazid E．p-aminosalicylic acid 65．Candidiasis of the vagina, gastrointestinal tract, and oral cavity is treated primarily by which of the following drugs? 【 A 】 A．Nystatin B．Miconazole C．Rifampin D．Griseofulvin E．Iodide 66．An inhibitor of DNA-dependent RNA polymerase, useful in tuberculosis, is 【 C 】 A．Isoniazid． B．Streptomycin． C．Rifampin． D．Ethambutol．E．Ethionamide． 67．All of the following drugs have clinically useful activity against Candida albicans EXCEPT【 C 】 A．Nystatin． B．Ketoconazole． C．Griseofuivin． D．AmphotericinB． E．Flucytosine． 68．This anticancer drug with specificity for the S phase of the cell cycle is activated by kinases to form an inhibitor of DNA polymerase．【 E 】