《传染病学》课程教学资源（PPT课件）Viral Hepatitis（肝炎）

Viral Hepatitis Yuan Zhe The First Affiliated Hospital Chongqing Medical University

Viral Hepatitis Yuan Zhe The First Affiliated Hospital Chongqing Medical University

Contents Viral etiology Epidemiology Pathogenesis Clinical manifestation Diagnosis Treatment Prevention guide

Contents Viral etiology Epidemiology Pathogenesis Clinical manifestation Diagnosis Treatment Prevention guide

THE VIRUS HAV:hepatitis A virus HBV:hepatitis B virus HCV:hepatitis C virus HDV:hepatitis D virus HEV:hepatitis E virus HGV:hepatitis G virus TTV:transfusion transmitted virus

THE VIRUS HAV: hepatitis A virus HBV: hepatitis B virus HCV: hepatitis C virus HDV: hepatitis D virus HEV: hepatitis E virus HGV：hepatitis G virus TTV： transfusion transmitted virus

Major Features of HAV Virion: Naked,spherical particle,diameter of 27nm Genome:Single-stranded linear RNA,7.5kb Genus:Heparnavirus,within the Picornaviridae family Stability:Room temp for 1 wk,85C for 1 sec, UV for 1 sec,in 70%alcohol for 3 min

Major Features of HAV Virion: Naked, spherical particle, diameter of 27nm Genome: Single-stranded linear RNA, 7.5kb Genus: Heparnavirus, within the Picornaviridae family Stability: Room temp for 1 wk, 85oC for 1 sec, UV for 1 sec, in 70% alcohol for 3 min

Major Features of HBV Virion: Enveloped,spherical particle,diameter of 42 nm,intermal core is 28 nm. Genome:3.2kb circular DNA,having four ORF in the complete strand,C,S,P and X genes. Genus: Hepadnavirus(HBV,WHV,GSHV,DHBV) Ag-Ab systems:HBSAg-Ab HBeAg-Ab HBcAg-Ab(IgG,IgM)

Major Features of HBV Virion: Enveloped, spherical particle, diameter of 42 nm, intermal core is 28 nm. Genome: 3.2kb circular DNA, having four ORF in the complete strand, C, S, P and X genes. Genus: Hepadnavirus(HBV, WHV, GSHV, DHBV) Ag-Ab systems: HBsAg-Ab HBeAg-Ab HBcAg-Ab(IgG, IgM)

HBV Stability Complete Condition Stable Inactivation Heat 60C for 4hr 100°Cfor10min

HBV Stability Complete Condition Stable Inactivation Heat 60oC for 4 hr 100oC for 10 min

Major Features of HCV Virion:Enveloped,spherical particle,diameter of 50-55 nm Nucleic acid:9.4 kb,a positive-stranded RNA molecule Genus:Flaviviridae family member Stability:Heat 60C for 10 hr,100C for 5min Formalin 1:1000,37℃，6hr Chloroform 10%-20%(vW),6hr

Major Features of HCV Virion: Enveloped, spherical particle, diameter of 50-55 nm Nucleic acid: 9.4 kb, a positive-stranded RNA molecule Genus: Flaviviridae family member Stability: Heat 60oC for 10 hr, 100oC for 5min Formalin 1:1000, 37oC, 6 hr Chloroform 10%-20%(v/v), 6 hr

Major Features of HDV Virion: HBsAg enveloped,spherical particle, diameter of 35-37 nm Genome: 1.78 kb,a negative-stranded, closed circular RNA molecule Stability: Heat 100C for 5min

Major Features of HDV Virion: HBsAg enveloped, spherical particle, diameter of 35-37 nm Genome: 1.78 kb, a negative-stranded, closed circular RNA molecule Stability: Heat 100oC for 5min

Major Features of HEV Virion: naked,spherical particle,diameter of 32~34 nm Genome:7.5 kb,a positive-stranded RNA molecule Genus: Indefinite Stability: sensitive to high temp,chloroform,etc

Major Features of HEV Virion: naked, spherical particle, diameter of 32~34 nm Genome: 7.5 kb, a positive-stranded RNA molecule Genus: Indefinite Stability: sensitive to high temp, chloroform, etc

Major Features of HGV Virion: Eenveloped virus Genome:9.1~9.4 kb,a positive-stranded RNA molecule Genus: Flaviviridae family Pathogenicity:Indefinite

Major Features of HGV Virion: Eenveloped virus Genome: 9.1~9.4 kb, a positive-stranded RNA molecule Genus: Flaviviridae family Pathogenicity: Indefinite