重庆医科大学：《内科学》课程教学课件（PPT讲稿）Leukemia（一）

Leukemia loushifeng

Leukemia loushifeng

Introduction ·Definition History 1827 Velpeal with his blood "like gruel" 1845 Benett,Edinburg,England. with "color and consistency of their blood"; Virchow Berlin,Germany introduced leukemia from Greek meaning "white blood

Introduction • Definition History 1827 Velpeal with his blood "like gruel” 1845 Benett ，Edinburg, England. with "color and consistency of their blood"; Virchow ，Berlin,Germany introduced leukemia from Greek meaning "white blood

正常外周血 病人外周血

Blo Myeloid Lymphoid Stem Cell Stem Cell Myeloblast Pronormoblast N.Promyelocyte Basophilic Normoblast Immature Immature N.Myelocyte Immature Basophil Eosinophil Monocyte Polychromatic Normoblast N.Metamyelocyte Normoblast Megakaryocyte N.Band Polychromatic Erythrocyte Basophil Eosinophil Neutrophil Monocyte Platelets Erythrocyte Lymphocyte

Myeloid Lymphoid Stem Cell Stem Cell Myeloblast Pronormoblast Basophilic Normoblast Immature Immature N.Myelocyte Immature Basophil Eosinophi nocyte Normoblast N.Metamyelocyte Orthochromatic Normoblast Megakaryocyte Polychromatic Erythrocyte Basophil Eosinophil Neutrophil Monocyte Platelets Erythrocyte Lymphocyte

Introduction ·Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow

Introduction • Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow

Introduction ·.Classification Acute Leukemia Acute lymphocytic Leukemia (ALL) Acute myelogenous Leukemia or Acute non- lymphocytic Leukemia (AML,ANLL) Chronic Leukemia Chronic Granulocytic Leukemia (CGL,CML) Chronic lymphocytic Leukemia (CLL) Leukemia uncommon in clinic

Introduction • Classification Acute Leukemia Acute lymphocytic Leukemia（ALL） Acute myelogenous Leukemia or Acute non￾lymphocytic Leukemia（AML，ANLL） Chronic Leukemia Chronic Granulocytic Leukemia（CGL，CML） Chronic lymphocytic Leukemia（CLL） Leukemia uncommon in clinic

Introduction 。.Incidence ·The total morbidity: 1.8 2.67/100 thousands 1.6 higher than the 1. 1.2 chance to win a 1 0.8 lottery(1/400 0.6 0.4 thousands 0.2 AML ALL CLL ·男：女=1.8：1

Introduction • Incidence • The total morbidity : 2.67/100 thousands higher than the chance to win a lottery(1/400 thousands ) • 男：女=1.8：1 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 AML ALL CLL

Introduction ·Prognosis 100% BMT CHEMO 0 1 2 3 4 5YEAR

Introduction • Prognosis 100% 0 1 2 3 4 5 YEAR BMT CHEMO

Introduction Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning lonizing radiation swell

• Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning Ionizing radiation Introduction swell