重庆医科大学：《内科学》课程教学课件（PPT讲稿）Leukemia（二）

Leukemia loushifeng

Leukemia loushifeng

Introduction ·Definition History 1827 Velpeal with his blood "like gruel 1845 Benett Edinburg,England. with "color and consistency of their blood"; Virchow Berlin,Germany introduced leukemia from Greek meaning "white blood

Introduction • Definition History 1827 Velpeal with his blood "like gruel 1845 Benett Edinburg, England. with "color and consistency of their blood"; Virchow Berlin,Germany introduced leukemia from Greek meaning "white blood

正常外周血 病人外周血

Introduction ·Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow

Introduction • Definition Leukemia is a group of clonal malignant deseases developed form hematopoietic stem cell or progenitor cell. that lead to Suppression of normal hematopoiesis Infiltrations in outside of bonemarrow

Introduction ·Classification Acute Leukemia Acute lymphocytic Leukemia (ALL) Acute myelogenous Leukemia or Acute non- lymphocytic Leukemia (AML,ANLL) Chronic Leukemia Chronic Granulocytic Leukemia (CGL,CML) Chronic lymphocytic Leukemia (CLL) Leukemia uncommon in clinic

Introduction • Classification Acute Leukemia Acute lymphocytic Leukemia（ALL） Acute myelogenous Leukemia or Acute non￾lymphocytic Leukemia（AML，ANLL） Chronic Leukemia Chronic Granulocytic Leukemia（CGL，CML） Chronic lymphocytic Leukemia（CLL） Leukemia uncommon in clinic

Introduction ·Incidence ·The total morbidity: 1.8 2.67/100 thousands 1.6 higher than the 1.4 1.2 chance to win a 1 0.8 lottery(1/400 0.6 0.4 thousands 0.2 AML ALL CLL 。男：女=1.8：1

Introduction • Incidence • The total morbidity : 2.67/100 thousands higher than the chance to win a lottery(1/400 thousands ) • 男：女=1.8：1 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 AML ALL CLL

Introduction ·Prognosis 100% BMT CHEMO 0 1 234 5 YEAR

Introduction • Prognosis 100% 0 1 2 3 4 5 YEAR BMT CHEMO

Introduction Etiology and Pathogenes Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning lonizing radiation

• Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning Ionizing radiation Introduction

Introduction ·Pathogenesis Normal Stem cell mutation Leukemic stem cell Progenitor cells Blast cell

Introduction • Pathogenesis Normal Stem cell Blast cell Leukemic stemcell mutation Progenitor cells

Introduction 1)those that confer a proliferative or and survival KIT FLT:3↑，NF-1↓ ● 2)those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC TEL- RONX1 fusions mutation

Introduction • 1)those that confer a proliferative or and survival KIT FLT3 ↑， NF-1 ↓ • 2) those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC ,TEL￾RONX1 fusions mutation