南方医科大学：《内科学》课程教学课件（讲稿）第八篇 风湿性疾病 第五章 系统性红斑狼疮（Systemic Lupus Erythematosus, SLE）

系统性红斑狼疮 Systemic Lupus Erythematosus 风湿免疫科毋静 南方医科大学第二临床医学院

Systemic Lupus Erythematosus 本意是“狼” 系统性红斑狼疮

Etiology Genetic factors Environment factors Sex and sex hormone 系统性红斑狼疮

Genetic factors 90.00% 同卵双生发病率 80.00% 70.00% 系统性红斑狼疮 60.00% 50.00% 40.00% 近亲发病率 30.00% 一般发病率 异卵双生发病率 20.00% 10.00% 0.00% general Close fraternal monozygotic population relatives twins twins 0.7% 5%-12% 3%-9% 24%-57%

HOME NEWS BUSINESS MONEY COMMENT SPORT VIDEO ENTERTAINMENT LIFE STYLE TRAVEL SH sisters Jennie and Jessie Gunhammar died within a year of each other -t- HEADLINES:alth Bill in Lords..... Oil and gas may last just 17 years.... Twins tragedy inspires action for lupus victims Louise Jury,Chief Arts Correspondent 28Apr2011 系统性红斑狼疮 An architect has launched a trust to help build the first walk-in centre for sufferers of an auto- immune disease that killed his partner and her twin sister. Andrew Clinch,49,will hold the first charity event next week in memory of photographer Jennie Gunhammar,his girlfriend of 15 years,and her twin, Jessie,an academic who lectured at the London School of Economics egacy:sisters Jennie and Jessie Gunhammar died within a year of each other Both died from lupus within a year of each other.Mr Clinch hopes the charity auction of artworks on Wednesday will raise the first E50,000 of the Sponsored links millions needed for a medical centre designed to offer a swifter route to diagnosis Ads by Google and help. Expat Living In China? He is working with friends at Debut gallery in Westbourne Grove.Its director, Samir Ceric,was one of the first to encourage Jennie's photographic career.By the Guide! time she died aged 34 in 2009 art experts including Vicente Todoli,then head of

Environment factors Infection 感染 Socialand psychological Sunlight 系统性红斑狼疮 pressure 日光 社会心理压力 SLE Biological Chemical 生物因素 化学物质 Drug 药品

Sex and sex hormone 系统性红斑狼疮 9000-76050443020100 Male Female 102030405060 70 80 Age

What causes Lupus? Genetically Damage susceptible individual 系统性红斑狼疮 Environmental Inflammation factors Auto antibody production

发病机制 在易感者中因免疫而耐受性减弱，B细胞通过 交叉反应与模拟外来抗原的自身抗原相结 系统性红斑狼疮 合，并将抗原递呈给T细胞，使之活化，在T细 胞活化刺激下，B细胞得以产生大量不同类 型的自身抗体，造成大量组织损伤 致病性自身抗体 致病性免疫复合物 ·调节性T细胞和NK细胞功能失调

ystemic Lupus Erythematosus Pleural Butterfly rash effusions Heart problems 系统性红斑狼疮 Auto-antibody Lupus nephritis 多 Symptoms of systemic lupus Arthritis erythematosus may vary widely 害 with the individual Raynaud's phenomenon ADAM