复旦大学：《儿科学》课程教学资源（PPT课件讲稿）第三讲 过敏性紫癜 Anaphylactoid Purpura 许兰-亨诺血管炎（综合征）Schonlein-Henoch vasculitis（syndrome）

过敏性紫癜 Anaphylactoid Purpura 许兰亨诺血管炎(综合征) Schonlein-Henoch vasculitis (syndrome) 儿科医院邬惊雷

过 敏 性 紫 癜 Anaphylactoid Purpura 许兰-亨诺血管炎(综合征) Schonlein-Henoch vasculitis(syndrome) 儿科医院 邬惊雷

概貌 Outline 是一种小血管炎 a kind of vasculitis of small vessels 以皮肤紫癜、关节痛、积液、腹痛、便血、血 尿和蛋白尿为主要临床特征 Characterized clinically by purpura, arthralgia articular effusion, abdominal pain, hemafecia, hematuria c and proteinuria

概 貌 Outline 是一种小血管炎 A kind of vasculitis of small vessels 以皮肤紫癜、关节痛、积液、腹痛、便血、血 尿和蛋白尿为主要临床特征 Characterized clinically by purpura, arthralgia ,articular effusion, abdominal pain, hemafecia, hematuria and proteinuria

学龄前和学龄期儿童多见 More frequent in preschoolers and school age children 男孩发病率高于女孩 Boys are affected more frequently than girls 估计人群总体发病率约为9/10万 The overall incidence estimated to be 9/100.000 population

学龄前和学龄期儿童多见 More frequent in preschoolers and school age children 男孩发病率高于女孩 Boys are affected more frequently than girls 估计人群总体发病率约为9/10万 The overall incidence estimated to be 9/100,000 population

病因 Etiology 病因不清楚,可能与下列因素有关 The etiology is unknown, maybe related with the follows 食物过敏:海鲜、蛋、牛奶 Food allergy: sea food eggs. milk 感染:细菌、病毒、寄生虫 Infection: bacteria, virus, parasites

病 因 Etiology 病因不清楚，可能与下列因素有关: The etiology is unknown, maybe related with the follows: 食物过敏：海鲜、蛋、牛奶 Food allergy: sea food, eggs, milk 感染：细菌、病毒、寄生虫 Infection: bacteria, virus , parasites

病因 Etiology 药物:抗生素、阿司匹林 Drugs: antibiotics, aspirin 其它:虫咬、预防接种 Others insect bite immunization

病 因 Etiology 药物：抗生素、阿司匹林 Drugs: antibiotics, aspirin 其它：虫咬、预防接种 Others: insect bite , immunization

病理改变 Histopathological findings 白细胞碎裂性血管炎 Leukocytoclastic vasculitis IgA为主的免疫复合物沉积 Deposition of immune complexes of IgA(in the small vessels and glomeruli)

病理改变Histopathological findings 白细胞碎裂性血管炎 Leukocytoclastic vasculitis IgA为主的免疫复合物沉积 Deposition of immune complexes of IgA(in the small vessels and glomeruli)

病理改变 Histopathological findings 肾脏病变:微小、局灶、新月体形成等 箭头所指处为新月体

病理改变Histopathological findings 肾脏病变：微小、局灶、新月体形成等 箭头所指处为新月体

临床表现 Clinical manifestations 常随上呼吸道感染后 Usaually follows an upper respiratory tract infection 可有低热、纳差、乏力 Low-grade fever, losing appetite and fatigue may occur

临床表现Clinical manifestations 常随上呼吸道感染后 Usaually follows an upper respiratory tract infection 可有低热、纳差、乏力 Low-grade fever, losing appetite and fatigue may occur

皮肤紫癜 Purpura 高出皮面,初期压之退色 Palpable purpura that initially blanch on pressure 反复出现,呈紫红色 Appear at intervals and evolve from red to purple 对称分布于腰以下 Occur symmetrically below the waist 尚可伴有血管神经性水肿 May have angioedema

皮肤紫癜 Purpura 高出皮面，初期压之退色 Palpable purpura that initially blanch on pressure 反复出现，呈紫红色 Appear at intervals and evolve from red to purple 对称分布于腰以下 Occur symmetrically below the waist 尚可伴有血管神经性水肿 May have angioedema

Pe-E 1岁半女孩患过敏性紫癜 注意:局限于半下身,明显的、边缘清楚分布的皮疹!

1 岁半女孩患过敏性紫癜： 注意：局限于半下身，明显的、边缘清楚分布的皮疹！