《核医学》课程电子教案（PPT教学课件）第九章 中枢神经系统

第九章 中枢神经系统 华中科技大学协和医院张永学

第九章 中枢神经系统 华中科技大学协和医院 张永学

Foreword To detect cerebral It is a effective arcanum diagnostic method ● To research thinking for nerval and and behavior activity psychic diseases a important tool

Foreword • To detect cerebral arcanum • To research thinking and behavior activity a important tool It is a effective diagnostic method for nerval and psychic diseases

Mainly Contents Regional cerebral blood flow imaging,rCBF Cerebral metabolism imaging 。 Neuroreceptor imaging 0（ CSF space imaging Radionuclide cerebral angiography Brain static imaging,blood brain barrier function

Mainly Contents • Regional cerebral blood flow imaging,rCBF • Cerebral metabolism imaging • Neuroreceptor imaging • CSF space imaging • Radionuclide cerebral angiography Brain static imaging, blood brain barrier function

Regional cerebral blood flow imaging,rCBF Intravenous injection imaging agent Pass blood brain barrier Distribution in brain cell follow blood flow Using SPECT to show cerebral perfusion and function

Regional cerebral blood flow imaging,rCBF • Intravenous injection imaging agent • Pass blood brain barrier • Distribution in brain cell follow blood flow • Using SPECT to show cerebral perfusion and function

lmaging agent and request Imaging agent Request 99mTc-HMPAO Small molecule(<400) 99mTc-ECD etc Zero charge 150-H20 Fat soluble Cerebra

Imaging agent and request Imaging agent 99mTc-HMPAO 99mTc-ECD etc 15O-H2O Request Small molecule(<400) Zero charge Fat soluble Cerebra l imaging

Cerebral blood flow tomography Transverse section Coronal Sagittal

Cerebral blood flow tomography Transverse section Coronal Sagittal

部黔 Normal cerebral blood flow tomogram

Normal cerebral blood flow tomogram

Clinical application Ischemic cerebral vascular diseases TIA:Transient ischemic attacks Cerebral infarction ·Epilepsy 。Dementia ·Brain tumor ·Brain function,etc

• Ischemic cerebral vascular diseases TIA: Transient ischemic attacks Cerebral infarction • Epilepsy • Dementia • Brain tumor • Brain function ,etc Clinical application

TIA Diagnostic positive rate was relative with period of disease 。 Positive rate was higher within 2 month of disease

TIA • Diagnostic positive rate was relative with period of disease • Positive rate was higher within 2 month of disease

TIA rCBF>23ml/ rCBF<23ml/1 rCBF<8ml/ 100g/min 00g/min 100g/min asymptomatic appear ischemic Occur cerebral structural ischemic symptom change (functional threshold Structure threshold SPECT CT、SPECT abnormal abnormal Normal≥50ml

rCBF>23ml/ 100g/min asymptomatic ischemic rCBF<23ml/1 00g/min appear ischemic symptom (functional threshold） SPECT abnormal rCBF<8ml/ 100g/min Occur cerebral structural change （Structure threshold） CT、SPECT abnormal Normal50ml