《病理生理学》课程教学课件（PPT讲稿）Chapter 2 Disorders Of Water And Electrolyte Metabolism（2/3）

EDEMAPathophysiologyDepartment, ShiHeZiMedical College,HUsT

Pathophysiology Department, ShiHeZi Medical College, HUST

488688ascitesIncreasedamountoffluidbetweenabdominal structuresLungPulmonaryedemaAccumulation offluid intheair sacs (alveoli)in the lungs

ascites Pulmonary edema

EdemaDefinition Pathogenesis Treatment

Edema • Definition • Pathogenesis • Treatment

Edema is defined as soft tissue swellingdue to expansion of the interstitial volume

Edema is defined as soft tissue swelling due to expansion of the interstitial volume

Pathogenesis★ Disturbance of Transcapillary Fluid Exchange★ Sodium and Water Retention

Pathogenesis ★ Disturbance of Transcapillary Fluid Exchange ★ Sodium and Water Retention

CapillaryPc=capillaryhydrostaticpressureP-=tissuehydrostaticpressureFiltrationReabsorptionTe=capillaryplasmaoncoticpressure元=tissuefluidoncoticpressureLymphFlowTerminal Lymphatic元cPc元T25mmHg20mmHg1-10mmHg15mmHg

Pc 20mmHg PT -10mmHg T 15mmHg C 25mmHg + - ﹝ + ﹞ 〉0

个CapillaryHydrostaticPressureInterstitialFluidVenousHydrostaticArterialOncoficendendpressurepressure20ydrostaticHydrostaticpressure18pressure37OncoticpressureCapillaryeg: thrombophebitis, hepatic obstruction, tight clothingaroundtheextremities,prolongedstanding

↑Capillary Hydrostatic Pressure eg: thrombophebitis, hepatic obstruction, tight clothing around the extremities, prolonged standing

ICapillaryPlasmaColloidOsmoticPressureInterstitial FluidVenousHydrostaticArterialOncoticendendpressurepressure20drostatidHydrostaticpressure18pressure37OncoticpressureCapillaryeg: glomerular diseases of the kidney,serous drainagefromopenwounds,burns,cirrhosisoftheliver

↓Capillary Plasma Colloid Osmotic Pressure eg: glomerular diseases of the kidney,serous drainage from open wounds,burns,cirrhosis of the liver

TissueFabMeHoReaagadtintpressureInterstitialFluidVenousHydrostaticArterialOncoticendendpressurepressure2OydrostaticHydrostaticpressure18pressure37Oncoticpressure25Capillaryeg:Severe inflammation

↑Tissue Fluid Colloid Osmotic Pressure eg: Severe inflammation ↑Capillary Permeability

Obstructionof LymphaticReturnCapillaryFiltrationReabsorptionLymphFlowTerminal Lymphatic

Obstruction of Lymphatic Return