《病理生理学》课程教学课件（PPT讲稿）Chapter 8 Stress And Stress-Related Diseases

STRESS AND STRESS.RELATEDDISEASESPathophysiology Department, ShiHeZi Medical College,HUST

STRESS AND STRESS￾RELATED DISEASES Pathophysiology Department, ShiHeZi Medical College, HUST

Contents1. Concepts: general adaptation syndromestress,stressor2.Mechanism-stress responseNeuroendocrine: LC-NE/sympathetic,HPAHumoral and cellular:APP,HSP3.Functional metabolic alteration4. Stress-related diseases: stress ulcer5.Prevention and treatment principle6. Case discussion

1. Concepts: general adaptation syndrome, stress, stressor 2. Mechanism-stress response • Neuroendocrine: LC-NE/sympathetic, HPA • Humoral and cellular: APP, HSP 3. Functional metabolic alteration 4. Stress-related diseases: stress ulcer 5. Prevention and treatment principle 6. Case discussion Contents

(From a wood engraving"The Light"by Fritz Eichenberg)RELIEFFROMSTRESSThe Physiology and Pathology Of Exposure ToHans SelyeSTRESS(1907-1982)HansSelye,MDDSeFRs.(190)

Hans Selye (1907-1982)

General Adaptation Syndrome(GAS)Specific symptomsDifferent diseasesNon-specific symptomsA serial of non-specific signs and symptoms causedby various strong stimulus

• General Adaptation Syndrome (GAS) A serial of non-specific signs and symptoms caused by various strong stimulus. Different diseases Specific symptoms Non-specific symptoms

General Principle of StressStimulusDisturbance of homeostasisAdaptativeresponse→HomeostasisDiseases or symptomsA generaladaptative response in order to copewith the altered homeostasis

A general adaptative response in order to cope with the altered homeostasis. Stimulus Diseases or symptoms Disturbance of homeostasis Adaptative response General Principle of Stress Homeostasis

Stages of GASStimulusAlarm reactionAdaptation---ExhaustionDiseasesRelaxation

Alarm reaction Stages of GAS Adaptation Exhaustion Relaxation Stimulus Diseases

Stress DefinitionNon-specific response of thebody to any demand madeupon it

Stress Definition Non-specific response of the body to any demand made upon it

StressorAny stimuli that elicit the stress responseExternalPhysicalShort-term(acute)InternalLong-term(chronic)PsychologicalPsycho-socialStressors: noise, danger, infectionon-going highly pressured work, long-termrelationship problems, loneliness, and persistentfinancial worries

Any stimuli that elicit the stress response External Internal Psycho-social Physical Psychological Stressor Short-term (acute) Long-term (chronic) Stressors: noise, danger, infection on-going highly pressured work, long-term relationship problems, loneliness, and persistent financial worries

Importanceof StressWithout stress, there would be no lifePleasant stress (eustresswellnessdiseaseUnpleasant stress (distress)

Pleasant stress (eustress) wellness Unpleasant stress (distress) disease Without stress, there would be no life Importance of Stress

Focus of Stress MechanismStimulusDisturbance of homeostasisAlarmreactionAdaptativeresponseDiseases or symptoms

• Stimulus Diseases or symptoms Disturbance of homeostasis Adaptative response Focus of Stress Mechanism Alarm reaction