《内科学》课程教学资源（PPT课件讲稿）呼吸衰竭 Respiratory Failure

Respiratory failure Zhang Xiao-ming Dept pathophysiology

1 Respiratory Failure Zhang Xiao-ming Dept. pathophysiology

ANATOMY OF THE LUNG Bronchi Trachea Capilla BLood Back to Heart Bl From The Heart Intrapleural g space Alveolus

3

RESPIRATION 4 distinct mechanisms: Ventilation Gas exchange J External respiration Transport of oxygen and carbon dioxide in the ood Internal respiration

4 RESPIRATION 4 distinct mechanisms: Ventilation Gas exchange External respiration Transport of oxygen and carbon dioxide in the blood Internal respiration

The Process of External respiration PiO 159mmH Pulmonary ventilation PO, 102mImH PACO2 40mmHg Pulmonary gas exchange Pao,40mmHg PaCo2 46mmHg PyO 100mmhs g PvCO, 40mmHg

5 The Process of External Respiration Pulmonary gas exchange PiO2 159mmHg PAO2 102mmHg PACO2 40mmHg Pulmonary ventilation PaO2 40mmHg PaCO2 46mmHg PvO2 100mmHg PvCO2 40mmHg

Definition of re Disorders of external respiratory function Pa0250 mmHg (6.67 kpa). judgment standard: Pao2 50 mmHg hypotonic hypoxia with(or without) respirator acidosis 6

6 Definition of RF Disorders of external respiratory function PaO2 50 mmHg(6.67kpa). judgment standard: PaO2 50 mmHg hypotonic hypoxia with (or without) respiratory acidosis

respiratory insufficiency It is a condition in which respiratory function is inadequate to meet body 's needs during exertion However, respiratory failure does so in rest a kind of respiratory insuficiency a severe respiratory insufficiency

7 respiratory insufficiency: It is a condition in which respiratory function is inadequate to meet body’s needs during exertion. However, respiratory failure does so in rest. a kind of respiratory insufficiency a severe respiratory insufficiency

Classification 1. According to blood gas 1) type I (hypoxemic RF) Pao2 50 mmHg(6.67 kpa)

8 Classification 1. According to blood gas: 1) typeⅠ(hypoxemic RF) : PaO2 50 mmHg(6.67kpa)

2. According to primary site central peripheral 3. According to duration acute chronic

9 2. According to primary site central peripheral 3. According to duration acute chronic

Section 1 Causes and pathogenesis of respiratory failure

10 Section 1 Causes and pathogenesis of respiratory failure

Pathogenesis of RF Disorders of external respiratory function pulmonary ventilation disturbance pulmonary gas exchange disturbance

11 • Pathogenesis of RF: Disorders of external respiratory function pulmonary ventilation disturbance pulmonary gas exchange disturbance