四川大学华西第二医院：化脓性脑膜炎（PPT课件讲稿）Suppurative Meningitis

Suppurative Meningitis 么vD Department of Neurology West China Second University Hospital

Suppurative Meningitis Yu Dan Department of Neurology West China Second University Hospital

公公 conception Bacteria VHi Irus Tuberculosis CNS Pathogen Fungus Parasite Spirochetal

CNS Pathogen Bacteria Virus Tuberculosis Fungus Parasite Spirochetal conception

Suppurative Meningitis 公公 Acute infection of central nervous system(CNS 90% of cases occur in the age of 1mo-5yr The inflammation of meninges caused by various bacteria. Common features in clinical practices include: fever, increased intracranial pressure, meningeal irritation One of the most potentially serious infections associated with high mortality(about 10%)and morbidity

 Acute infection of central nervous system(CNS). 90% of cases occur in the age of 1mo-5yr.  The inflammation of meninges caused by various bacteria. Common features in clinical practices include: fever, increased intracranial pressure, meningeal irritation.  One of the most potentially serious infections, associated with high mortality (about 10%) and morbidity. Suppurative Meningitis

Suppurative Meningitis 公公 Etiology Predisposing factors Pathology Clinical manifestation Diagnosis and Differential Diagnosis Treatment Complication

Suppurative Meningitis Etiology Predisposing factors Pathology Clinical manifestation Diagnosis and Differential Diagnosis Treatment Complication

Acute Suppurative meningitis 公公 Etiology. First 2 months of life: Group B Streptococcus, gram negative bacilli, S pneumoniae, Neisseria meningitides, Haemophilus influenzae type b and L. monocytogenes Children 2 mo-12yr of age 1-s. pneumoniae 2-N. meningitides Alterations of host defense Pseudomonas aeruginosa, Staphylococcus aureus, salmonella spp, and L. monocytogenes

Acute Suppurative Meningitis Etiology: First 2 months of life: Group B Streptococcus, gram negative bacilli, S. pneumoniae, Neisseria meningitides, Haemophilus influenzae type b. and L. monocytogenes. Children 2 mo-12yr of age 1- S. pneumoniae 2- N. meningitides Alterations of host defense: Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella spp., and L. monocytogenes

公公 There are 3 main bacterial meningeal pathogens 1. Haemophilus influenzae 2. Neisseria meningitides 3. Streptococcus pneumoniae *Incidence varies by region and age

*There are 3 main bacterial meningeal pathogens: 1. Haemophilus influenzae 2. Neisseria meningitides 3. Streptococcus pneumoniae *Incidence varies by region and age

公公 Haemophilus influenzae a Small GN, pleomorphic coccobac 2 H flu type B causes almost ALL invasive disease a Nontypeable Hib can rarely cause meningitis. 7 Incidence of hib decreased by 97% after vaccine

Haemophilus influenzae  Small GN, pleomorphic, coccobacilli  H. flu type B causes almost ALL invasive disease  Nontypeable Hib can rarely cause meningitis.  Incidence of Hib decreased by 97% after vaccine

公公 +Occurs predominantly in infants 2mo to 2yr of age Many cases are in winter Higher incidence of subdural effusion

 Occurs predominantly in infants 2mo to 2yr of age  Many cases are in winter  Higher incidence of subdural effusion

Neisseria meningitidis 公公 Gn diplococci Serotypes A, B, C,Y, and W135 cause most invasive di sease. Virulence depends on: C capsular polysaccharide 2. LPS(endotoxin) 3. Pili 4.IgA protease 5. ompS gene

Neisseria meningitidis  - GN diplococci  - Serotypes A,B,C,Y, and W135 cause most invasive disease.  - Virulence depends on: 1. Capsular polysaccharide 2. LPS(endotoxin) 3. Pili 4. IgA protease 5. ompS gene

公公 Occur in epidemics(type A, C), which Is more common In spring, or sporadic all the year(type B,C,Y

Occur in epidemics (type A,C), which is more common in spring, or sporadic all the year (type B,C,Y)