复旦大学：《病理学 Pathology》课程英文PPT课件_Chapter XV Infections Diseases & Parasitic Diseases

Infectious disease Latent

Infectious disease Department of pathology Hui Li huili78@fudan.edu.cn

COmLARD DAMON FISHBURNE LAW PALTROW WINSLET NOTHING SPREADS LIKE FEAR CONTAGION SEPTEMBER 9

UNIV Infectious disease 2 Common Features 1/Etiology pathogenIc microbes parasite 2. epidemiology source of infection s. route of transmission Susceptible population 3. Pathogenesis ☆ entry cell toxin /enzyme, vessel injury ☆ Immune response

1. Etiology: pathogenic microbes parasite 2. epidemiology ❖ source of infection ❖ route of transmission ❖ Susceptible population 3. Pathogenesis ❖ entry cell ❖ toxin /enzyme, vessel injury ❖ immune response Infectious Disease Common Features

UNIV ∠e。%(麻风

Leprosy (麻风)

UNIV Introduction History Epidemiology Harm

History Epidemiology Harm Introduction

UNIV Etiology ◆M/ prae Discovered in norway inl 873 by dr Armauer hansen Acid-fast obligate in tracellular bacterium Prefer low tempreture(32 to 34C)and 影A3 grow slowly virulence is based on properties of its ce elI wall Human being seems to be the only victim

Etiology  M. leprae  Discovered in Norway in1873 by Dr. Armauer Hansen  Acid-fast obligate in tracellular bacterium Prefer low tempreture (32 to 34℃) and grow slowly  virulence is based on properties of its cell wall Human being seems to be the only victim

UNIV 7 cavsuisoiove Contained in secretion Respiratory pathway Abrasion or wounds Taken up by macrophages disseminates through the blood

Transmission  Contained in secretion  Respiratory pathway Abrasion or wounds  Taken up by macrophages  disseminates through the blood

UNIV clinical cowie Latant period: 2-4 years ◆ Cellular immunity ◆ Humoral immunity ◆ Lepromin test

Clinical course  Latant period: 2-4 years  Cellular immunity  Humoral immunity  Lepromin test

UNIV ◆ a bipolar disease tuberculoid leprosy(T-cell mediated Immune response lepromatous leprosy(Immunity anergic) epromin test

Pathogenesis  A bipolar disease tuberculoid leprosy (T-cell mediated immune response ) lepromatous leprosy (Immunity anergic)  Lepromin test

UNIV Why leprosy runs varying courses in different persons? Individuals who recognized certain M leprae antigens and had no disease showed different alleles at the human Bcg locus which was verified to control responses to intracellular bacteria and parasItes

Pathogenesis  Why leprosy runs varying courses in different persons? Individuals who recognized certain M. leprae antigens and had no disease showed different alleles at the human Bcg locus which was verified to control responses to intracellular bacteria and parasites