复旦大学：《肿瘤学概论 Basics of Clinical Oncology》课程PPT教学课件（英文）基础临床肿瘤系统治疗 Basic Clinical Oncology Systemic Therapy

Fudan University Shanghai cancer Center 《 Basic clinical oncology》 Fudan University Cancer Center Bi Yun wang (Associate Professor, Dept of Medical Oncology) Arrrr 复旦大学上海医学院肿瘤学糸

复旦大学上海医学院肿瘤学系 Fudan University Shanghai Cancer Center 《Basic Clinical Oncology》 Fudan University Cancer Center Bi Yun Wang (Associate Professor, Dept. of Medical Oncology)

Self Introduction Graduated from uSMc Medical oncologist in Cancer hospital Major: Systemic Therapy for Breast Cancer

Self Introduction • Graduated from FUSMC • Medical Oncologist in Cancer Hospital • Major: Systemic Therapy for Breast Cancer

Systemic Therapy

Systemic Therapy

Introduction Systemic therapy Chemotherapy Hormonal therapy Target therapy

Introduction • Systemic therapy – Chemotherapy – Hormonal therapy – Target therapy

Outlines History of Drug Discovery New drug development and clinical trials Chemotherapy Development Targeted Agents and New Directions in Drug Development Clinical Uses of Systemic Therapy Systemic Therapy Process

Outlines • History of Drug Discovery • New drug development and clinical trials • Chemotherapy Development • Targeted Agents and New Directions in Drug Development • Clinical Uses of Systemic Therapy • Systemic Therapy Process

Outlines History of Drug Discovery New drug development and clinical trials Chemotherapy Development Targeted Agents and New Directions in Drug Development Clinical Uses of Systemic Therapy Systemic Therapy Process

Outlines • History of Drug Discovery • New drug development and clinical trials • Chemotherapy Development • Targeted Agents and New Directions in Drug Development • Clinical Uses of Systemic Therapy • Systemic Therapy Process

History of drug discovery Beginning of modern chemotherapy First clinical trial of Nitrogen mustard in ymphoma at yale in 1942 Regressions of lymphomas generated excitement for chemotherapy Results published in 1946

History of drug discovery • Beginning of modern chemotherapy – First clinical trial of Nitrogen mustard in Lymphoma at Yale in 1942 – Regressions of lymphomas generated excitement for chemotherapy – Results published in 1946

Outlines History of Drug Discovery New drug development and clinical trials Chemotherapy Development Targeted Agents and New Directions in Drug Development Clinical Uses of Systemic Therapy Systemic Therapy Process

Outlines • History of Drug Discovery • New drug development and clinical trials • Chemotherapy Development • Targeted Agents and New Directions in Drug Development • Clinical Uses of Systemic Therapy • Systemic Therapy Process

New drug development and clinical trials New drug development Screening to exploit new therapeutic targets Basic cancer research Experimental animal tumor models Human cancer cell lines C linical trials Phase phase ll. phase lll

New drug development and clinical trials • New drug development – Screening to exploit new therapeutic targets – Basic cancer research • Experimental animal tumor models • Human cancer cell lines – Clinical trials • Phase I, Phase II, Phase III

Phase Trial Objectives Describe pharmacokinetics and toxicity Cytotoxic drug MTD(maximally tolerated dose RTD(Recommended dose) DLT( dose-limiting toxicity)

Phase I Trial • Objectives Describe pharmacokinetics and toxicity • Cytotoxic drug – MTD (maximally tolerated dose) – RTD (Recommended dose) – DLT (dose-limiting toxicity)