北京大学：《病理学》课程PPT教学课件（英文版）Section B Degeneration

Section B Degeneration ACUTE CELLULAR SWELLING

Degeneration ACUTE CELLULAR SWELLING

心 6 净之 肝细胞水肿 J

肝细胞水肿

FATTY CHANGE Excessive entry of free fatty acids into the liver (starvation, corticosteroid therapy) Enhanced fatty acid synthesis. Decreased fatty acid oxidation. Increased esterification of fatty acid to triglycerides(alcohol) Decreased apoprotein synthesis(Ccla). Impaired lipoprotein secretion from the liver (alcohol)

• Excessive entry of free fatty acids into the liver (starvation, corticosteroid therapy). • Enhanced fatty acid synthesis. • Decreased fatty acid oxidation. • Increased esterification of fatty acid to triglycerides (alcohol). • Decreased apoprotein synthesis (CCl4). • Impaired lipoprotein secretion from the liver (alcohol). FATTY CHANGE

Morphology of fatty change Sudan ii oil red o. osmic acid Liver heart e Kidney

•Morphology of fatty change Sudan III, Oil red O, Osmic acid •Liver •Heart •Kidney

肝脂肪变性

,, 3 肝脂肪变性

Hyaline changes(degeneration) Intracellular hyaline changes Hyaline degeneration of arterioles Hyaline degeneration of connective tissue

•Intracellular hyaline changes •Hyaline degeneration of arterioles •Hyaline degeneration of connective tissue Hyaline changes (degeneration)

Intracellular hyaline changes Absorption of protein causing hyaline droplets in proximal epithelial cells in the kidney. Russel bodies in plasma cells Viral inclusions in the cytoplasm or the nucleus Masses of altered intermediate filaments Mallory bodies)

• Absorption of protein causing hyaline droplets in proximal epithelial cells in the kidney. • Russel bodies in plasma cells. • Viral inclusions in the cytoplasm or the nucleus. • Masses of altered intermediate filaments (Mallory bodies). Intracellular hyaline changes

M④。 肾小管上皮玻璃样变