北京大学：《病理学》课程PPT教学课件（英文版）Section C CELL DEATH

Section C CELL DEATH

CELL DEATH

Common type of necrosis after exogenous stimuli。 Swelling, denaturation and coagulation of proteins Breakdown of cellular organelles Cell rupture

• Swelling, denaturation and coagulation of proteins • Breakdown of cellular organelles • Cell rupture Common type of necrosis after exogenous stimuli

NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ Denaturation of proteins. Enzymatic digestion of organelles and cytosol

NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ: • Denaturation of proteins. • Enzymatic digestion of organelles and cytosol

AUTOLYSIS Enzymatic digestion by lysosomal enzymes of the dead cells themselves HETEROLYSIS Digestion by lysosomal enzymes of immigrant leukocytes

•Enzymatic digestion by lysosomal enzymes of the dead cells themselves. AUTOLYSIS HETEROLYSIS • Digestion by lysosomal enzymes of immigrant leukocytes

Three pattern of nuclear changes Karyolysis(DNase activity) Pyknosis ( dna condensation) Karyorrhexis(fragmentation of pyknotic nucleus)

Three pattern of nuclear changes Karyolysis (DNase activity) Pyknosis (DNA condensation) Karyorrhexis (fragmentation of pyknotic nucleus)

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Morphologic appearance of necrosis Increased eosinopl philia Loss of rna in the cytoplasm Increased binding of eosin to denatured cytoplasmic protein More glassy homogeneous appearance Loss of glycogen particles Vacuolated and moth-eaten cytoplasm Calcification of necrotic cells

Morphologic appearance of necrosis • Increased eosinophilia: Loss of RNA in the cytoplasm Increased binding of eosin to denatured cytoplasmic protein • More glassy homogeneous appearance Loss of glycogen particles • Vacuolated and moth-eaten cytoplasm • Calcification of necrotic cells

TYPES OF CELL DEATH necrosis Coagulation necrosis Caseous necrosis Gangrene Liquefaction necrosis( fat necrosis) fibrinoid necrosis Apoptosis

TYPES OF CELL DEATH • necrosis Coagulation necrosis Caseous necrosis Gangrene Liquefaction necrosis( fat necrosis) Fibrinoid necrosis • Apoptosis

Coagulation necrosis Denatures of both structural and enzymatic proteins by injury or the subsequent increasing intracellular acidosis

Coagulation necrosis Denatures of both structural and enzymatic proteins by injury or the subsequent increasing intracellular acidosis

肾凝固性坏死