浙江大学医学院：《生理学》课程教学资源（PPT课件讲稿）心血管活动的调节 Regulation of Cardiovascular Activities

Requlation of Cardiovascular Activities Qiang X|A(夏强),PhD Department of Physiology Zhejiang University School of Medicine Te:88206417.88208252 Email:xiaqiang@zju.edu.cn

Regulation of Cardiovascular Activities Qiang XIA (夏强), PhD Department of Physiology Zhejiang University School of Medicine Tel: 88206417, 88208252 Email: xiaqiang@zju.edu.cn

Nervous Requlation Vasomotor cent Blood vagus Heart Vasoconstrictor Cardioinhibitor vasodilator Blood

Nervous Regulation

Innervation of the heart Cardiac sympathetic nerve Cardiac vagus nerve 1.起源 origin 2.节前纤维 preganglionic fiber 3.外周神经节 ganglion 4.节后纤维 postganglionic fiber 5.支配 distribution 6.递质 neurotransmitter

Innervation of the heart • Cardiac sympathetic nerve • Cardiac vagus nerve 1. 起源origin 2. 节前纤维preganglionic fiber 3. 外周神经节ganglion 4. 节后纤维postganglionic fiber 5. 支配distribution 6. 递质neurotransmitter

Ix afferent Carotid Medullary <. afferent Sinuses cardiovascular G centre Vagal mot Aortic baroreceptor Sympathetic effer T-十 Acetylcholine Vessel Sinu Interneuron node muscarinIc Adrenaline in blood Noradrenaline Acetylcholine transmitter Sympathetic stimulation increases contractility, frequency, conduction velocity, and irritability

Heart Blood vessel Vasoconstriction Entropy ChronotropyHt NE+NE十>NE→ Vasoconstriction Vas dilation Dromotropy Sympathetic Vasodilation Nerve Terminal ACh Parasympathetic Nerve Terminal Nerve Terminal gic Sympathetic Choliner

Cardiac sympathetic actions Positive chronotropic effect正性变时作用 Positive dromotropic effect正性变传导作用 Positive inotropic effect正性变力作用

Cardiac sympathetic actions • Positive chronotropic effect正性变时作用 • Positive dromotropic effect正性变传导作用 • Positive inotropic effect正性变力作用

Cardiac mechanisms of norepinephrine Na(le) ACh N。rEp Muscarinic Beta-1 Receptor Receptor G G Stimulate Stimulates K Inhibition Cyclic-AMP

Cardiac mechanisms of norepinephrine

Mechanisms of norepinephrine -increase Nat cazt permeability 个, phase4 spontaneous depolarization个, autorhythmicity↑ Ca2 influx(ca)↑, phase 0 amplitude& velocity↑, conductivity个 Ca2 influx(ca)↑,Ca2+ release个,[Ca2+]个, contractility↑ (CICR)

Mechanisms of norepinephrine —increase Na+ & Ca2+ permeability • I f , phase 4 spontaneous depolarization, autorhythmicity  • Ca2+ influx (ICa,L) , phase 0 amplitude & velocity , conductivity  • Ca2+ influx (ICa,L) , Ca2+ release , [Ca2+ ] i , contractility  (CICR)

Asymmetrical 899t0 innervation of sympathetic nerve 59E Time(min)

Asymmetrical innervation of sympathetic nerve

Cardiac parasympathetic actions Negative chronotropic effect负性变时作用 Negative dromotropic effect性变传导作用 Negative inotropic effect性变力作用

Cardiac parasympathetic actions • Negative chronotropic effect负性变时作用 • Negative dromotropic effect负性变传导作用 • Negative inotropic effect负性变力作用