复旦大学：《流行病学 Epidemiology》课程教学资源（课件讲义）实验流行病学（主讲：赵琦）

Today:2014/6/4 实验流行病学 赵琦 流行病学教研室 Today: 4 June 201

Today: 4 June 2014 Today：2014/6/4 实验流行病学 赵 琦 流行病学教研室

学习目的 ·掌握实验流行病学的基本概念 ·掌握实验流行病学的研究设计 ·了解常见实验流行病学研究方法 Today: 4 June 201

Today: 4 June 2014 学习目的 • 掌握实验流行病学的基本概念 • 掌握实验流行病学的研究设计 • 了解常见实验流行病学研究方法

CITRUS FRUIT SCURVY JAMES LIND THE FIRST PLANNED, CONTROLLED CLINICAL TRIAL Today: 4 June 201

Today: 4 June 2014 CITRUS FRUIT & SCURVY JAMES LIND – THE FIRST PLANNED, CONTROLLED CLINICAL TRIAL

18TH CENTURY NAVY LIFE THE NUMBER OF SEAMAN IN TIME OF WAR WHO DIED OF SHIPWRECK CAPTURE, FAMINE, FIRE OR SWORD, ARE BUT OF INCONSIDERABLE IN RESPECT OF SUCH AS ARE DESTROYED BY THE SHIP DISEASES, AND BY THE USUAL MALADIES OF INTEMPERATE CLIMATES. JAMES LIND, 1753 Today: 4 June 201

Today: 4 June 2014 18TH CENTURY NAVY LIFE “THE NUMBER OF SEAMAN IN TIME OF WAR WHO DIED OF SHIPWRECK, CAPTURE, FAMINE, FIRE OR SWORD, ARE BUT OF INCONSIDERABLE IN RESPECT OF SUCH AS ARE DESTROYED BY THE SHIP DISEASES, AND BY THE USUAL MALADIES OF INTEMPERATE CLIMATES.” - JAMES LIND, 1753

Typical Diet: HMS Salisbury 3 days / week 1|b.40z.0f 2 oZ dried fish cheese biscuits and butter 1 gallon of beer 2 days/ week 4 days /week 2 Ib salted beef 8 oz peas Today: 4 June 201

Today: 4 June 2014 Typical Diet:HMS Salisbury Daily 1 lb., 4 oz. of cheese biscuits 1 gallon of beer 2 days / week 2 lb. salted beef 3 days / week 2 oz. dried fish and butter 4 days / week 8 oz. peas

AAAA AA 巅巅巅巅 study design: usual diet dietary supplement(6 options) Today: 4 June 201

Today: 4 June 2014 Study Design: usual diet + dietary supplement (6 options)

AA Quart of apple juice daily Today: 4 June 201

Today: 4 June 2014 Quart of apple juice daily

25 drops of elixir vitriol (sulfuric acid and aromatics) Today: 4 June 201

Today: 4 June 2014 25 drops of elixir vitriol (sulfuric acid and aromatics)

AA 2 spoonfuls of vinegar 3 times a da Today: 4 June 201

Today: 4 June 2014 2 spoonfuls of vinegar 3 times a day

Concoction of herbs and spices Today: 4 June 201

Today: 4 June 2014 Concoction of herbs and spices