重庆医科大学：《小儿感染病学》课程教学课件（PPT讲稿）麻疹 MEASLES（英文）

MEASLES DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY 7

1 MEASLES DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

圆Key_points MEASLES Acute respiratory infectious disease caused by measles virus clinical feature:Fever,Cough,Runny nose,Conjunctivitis,Exanthem Specific sign:Koplik's Spots (a kind of enanthem） 2 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

2 Key points MEASLES DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY ◆ Acute respiratory infectious disease caused by measles virus ◆ clinical feature: Fever, Cough, Runny nose, Conjunctivitis, Exanthem ◆ Specific sign: Koplik’s Spots (a kind of enanthem )

Pathogen Classification:A RNA virus Genus:morbillivirus Family:paramyxoviridae Serotype:Only one Location:Nasopharyngeal secretions, Blood,Urine of patients DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

3 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Classification: A RNA virus Genus: morbillivirus Family: paramyxoviridae Serotype: Only one Location: Nasopharyngeal secretions, Blood, Urine of patients Pathogen

● Pathogen measles virus DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

4 Pathogen DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY measles virus

Epidemiology 1.Infectious sources:Measles patients in acute stage 2.Routes of transmission:Droplet spray 3.Population susceptibility: It is susceptible to all the people without infection or inoculation. The age of peak incidence was 6 months to 5 years old. The incidence of baby under 6m is lower. 4.Epidemic features: 5 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

5 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Epidemiology 1.Infectious sources：Measles patients in acute stage 2.Routes of transmission： Droplet spray 3.Population susceptibility： 4.Epidemic features： ⚫ It is susceptible to all the people without infection or inoculation. ⚫ The age of peak incidence was 6 months to 5 years old. ⚫ The incidence of baby under 6m is lower

Epidemiology Routes of transmission Droplet spray DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

6 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Routes of transmission Epidemiology Droplet spray

Epidemiology Epidemic Features Prior to the use of vaccine After the use of vaccine Morbidity Major epidemics:500-1000 9.5in1990 (1/100000) Mild epidemics:400 Peak season In winter and spring In any time of a year Epidemic cycle Major epidemics appear by Epidemic cycle disappeared,Sporadic 2-4 yr intervals cases increased Age 6m-5y(98K10y) Below 6m and above 5y Typical cases Atypical cases Clinical severe manifestations mild manifestations manifestations more complications less complications high mortality rarely death DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY

7 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Prior to the use of vaccine After the use of vaccine Morbidity (1/100000) Major epidemics: 500-1000 Mild epidemics: 400 9.5 in 1990 Peak season In winter and spring In any time of a year Epidemic cycle Major epidemics appear by 2-4 yr intervals Epidemic cycle disappeared, Sporadic cases increased Age 6m-5y (98%<10y) Below 6m and above 5y Clinical manifestations Typical cases severe manifestations more complications high mortality Atypical cases mild manifestations less complications rarely death Epidemiology Epidemic Features

Measles 1980:Incidence and Immunization Immunization(MCV1)coverage %80%100% 750%-80% 10.50% No Data Incidence per 100,000 people 0-15 15.50 50-100 100-500 500+ No Data UC Atlas of Global Inequality Data:World Health Organization www3.who.int/whosis(Incidence and Immunization) http://www2.ucsc.edu/atlas/ World Bank,World Development Indicators 2002(Population) Created 16 December 2002

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Measles 2000:Incidence and Immunization Immunization(MCV1)coverage 50%-80% 0.50% No Data Incidence per 100,000 people 0-15 15.50 50.100 100.500 500+ No Data UC Atlas of Global Inequality http://www2.ucsc.edu/atlas/ Data:World Health Organization www3.who.int/whosis(Incidence and Immunization) eated 16 December 2002 World Bank,World Development Indicators 2002(Population)

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2000 1800 1728 1670 1600 : 1400 ◆ ◆ Measles Vaccine 1200 1125 Inoculation in whole 1000 China (1988) : 800 ◆ 595 600 493 480 383 400 293 297 250 95 200 152139 155 1兴 2213721 1960 64 68 72 76 80 84 88 92 96 200020072009 Measles cases of in-patients in CHCMU 10

10 265 1138 1728 1125 192 493 595 250 293 383 195 152 139 2 2 1 3 7 2 1 110 155 120 297 480 1670 725 130 0 200 400 600 800 1000 1200 1400 1600 1800 2000 1960 6 4 6 8 7 2 7 6 8 0 8 4 8 8 9 2 9 6 2000 2007 2009 Measles cases of in-patients in CHCMU Measles Vaccine Inoculation in whole China (1968)