重庆医科大学：《重症医学》课程教学课件（讲稿）脂肪栓塞 Fat Embolism Syndrome

Fat Embolism Syndrome

CASE

CASE

Q1: Why the patient with the fracture of thedtibiaadmittedintoICU,andfemurandreceivedmechanicalventilation?Q2:What'stheprognosis of this disease?Isitreallysevere?prevent this?Q3 : How can we

Q1：Why the patient with the fracture of the femur and tibia admitted into ICU, and received mechanical ventilation? Q2：What’s the prognosis of this disease? Is it really severe? Q3： How can we prevent this?

IntroductionAetiologyPathophysiologySympotoms and signsDiagnosisTreatment

IntroductionAetiologyPathophysiologySympotoms and signsDiagnosisTreatment

IntroductionFESrefersto the constellation of clinical manifestationsthatmaydevelop when fat droplets become impactedin the small vessels of pulmonary and other organs,especially in the brain. The principal clinical featuresare respiratory failure, cerebral dysfunction,andpetechia.Petechia: means some red points of skin because ofthe subcutaneous hemorrhage

FES refers to the constellation of clinical manifestations that may develop when fat droplets become impacted in the small vessels of pulmonary and other organs, especially in the brain. The principal clinical features are respiratory failure, cerebral dysfunction, and petechia. Introduction Petechia: means some red points of skin because of the subcutaneous hemorrhage

IntroductionThis definition provides us withinformations as followed:First,it is necessary to develop this disease that the fatembolipassesinto the small vesselsof thelungandotherorgans;Second,when the fat emboli arrives in thelung and otherorgans,it inducesthe damage,and it leadsto multisystemdysfunctionTypically,insomecases,we canseeamountof petechiaovertheupperhalfof body

Introduction

IntroductionZenker1862Fat embolism was first describedBergman1873Fatembolismsyndromewasfirstreportedinclinic

Zenker 1862 Fat embolism was first described Bergman 1873 Fat embolism syndrome was first reported in clinic. Introduction

Introduction8%MortalityIf therearesome complications,such asshock,infectionand et al,the mortalitycanincreaseto50%-62%

Mortality 8％ If there are some complications, such as shock, infection and et al, the mortality can increase to 50％-62％ Introduction

IntroductionAetiologyPathophysiologySympotoms and signsDiagnosisTreatment