西北农林科技大学：《有机化学 Organic chemistry》课程PPT教学课件（2018）McMurry OCB 3Ed Chapter 00 Introduction to the course（主讲：王俊儒）

Organic Chemistry with BiologicalApplications,3rEdition John McMurry ORGANIC CHEMISTRY For Undergraduates in Biological Science JOHN MCMURRY Organic Chemistry with Biological Applications By Junru Wang College of Chemistry and Pharmacy Room C206,Science Building Tel:87092829(0);Email:wangjr07@163.com

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com ORGANIC CHEMISTRY For Undergraduates in Biological Science Organic Chemistry with Biological Applications, 3 rd Edition John McMurry

OHN MCMURE Organic Chemistry with BiologicalApplications,3rEdition John McMurry Organic CHemistry 4 Qs: 1.What Is Organic Chemistry? 2.What Will We Learn From It? 3.How To Study? 4.What Is Your Goal? By Junru Wang College of Chemistry and Pharmacy Room C206,Science Building Tel:87092829(0);Email:wangjr07@163.com

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com Organic Chemistry with Biological Applications, 3 rd Edition John McMurry 4 Qs : 1.What Is Organic Chemistry? 2.What Will We Learn From It? 3.How To Study? 4.What Is Your Goal?

htp://www.nature.com/nature/jouma32/n14/abs/32099a0.html 0,8dX hao123Organic che..VirtualText of...si>An Intr..x 文件的编端日看收痘夫肉工具D帮助州 Nature32,99-100(04June1885)doi:10.1038/032099a0 a■0■■■0a■■■■■1 An Introduction to the Study of the Compounds of Carbon;of Organic Chemistry science.ine student wno pegins tne stuay or tne carDon Web focuses compounds has to suffer many things from the text-books.Some ☒Send to a friend of them present him with dry bones in the shape of isolated facts Podcasts and bold assertions regarding structural formulae and the linking Rights and permission +Videos of atoms.Others lead him into speculations which he is unprepared to follow;he makes little flights into these and comes Order commercial reprints +News Specials back fancying he is a chemist.Other books(there are not many of them)proceed on the true scientific lines;but very frequently their pages are encumbered with too many facts about more or less Journal widely separated compounds,or they deal so much with groups of open innovation information compounds,rather than with typical individual bodies,that the challenges About the journal beginner soon loses his way,becomes perplexed,and is ready to Future Clothes Washing abandon the pursuit. Technoloav

WHAT is Organic Chemistry? Organic Chemistry is... >the study of the compounds of carbon >the science of carbon compounds >the chemistry of the compounds of carbon >"the chemistry of living things" 基本概念都是围绕碳的特性建立起来的 ⊕ a Carbocation a Carbon Radical a Carbanion

Organic Chemistry is… ➢the study of the compounds of carbon ➢the science of carbon compounds ➢the chemistry of the compounds of carbon ➢“the chemistry of living things” 基本概念都是围绕碳的特性建立起来的 C+ C· C￾WHAT is Organic Chemistry?

Scientific Revolution Scientific revolution leads to: Safer and more effective medicines Cures for genetic diseases CH3 CH3CH2CH=CHCH2CONH ■Increased life span CH3 COONa ■ Improved quality of life 2-Pentenylpenicillin Scientific advances in medicine and biology require an understanding of organic chemistry

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com Scientific revolution leads to: ◼ Safer and more effective medicines ◼ Cures for genetic diseases ◼ Increased life span ◼ Improved quality of life Scientific advances in medicine and biology require an understanding of organic chemistry. Scientific Revolution 2-Pentenylpenicillin N S CHCH2CONH H H O CH3 CH3 COONa CH3CH2CH

Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol leě#病 75%of blood cholesterol (1000 mg a day)is biosynthesized Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类药物 他汀类降血脂药) 3-Hydroxy-3-methylglutaryI coenzyme A(HMG-CoA)to mevalonate conversion3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin (Lipitor)inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▣阿托伐他汀

Organic and Biological Chemistry in Modern Medicine ◆Coronary artery disease (CAD) is directly correlated with blood cholesterol levels ▪ 75% of blood cholesterol (1000 mg a day) is biosynthesized ▪Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels ◆3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion ▪ Crucial step in biosynthesis of cholesterol ▪ Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▪ 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）

H3C OH H3C OH CH3 02C SCoA OH HO 3-Hydroxy-3-methyl- Mevalonate Cholesterol glutaryl coenzyme A (HMG-CoA) H K692 K691 HO. c02 Lo6 OH D6 H R556 R590 3.2 CH3 27 H752 S684 L562 K735 CH3 L853 V683 L967 1850 R508 Atorvastatin (Lipitor)

The future mission of Chemistry? Angewandte GDCh Ajoumal of the Gesellschaf Chemie Deutscher Chemiker Explore this journal Volume 54,Issue 11 Essay March 9,2015 Pages3196-3209 Reinventing Chemistry The chemistry must expand Angewandte Prof.George M.Whitesides First published:12 February 2015 Full publicatior its mission from "molecules," DOI:10.1002/anie.201410884 View/save citation Cited by:25 articles Citation tool to "everything that involves 4-4-1 molecules." View issue TOC Special Issue: 150 Years of BASF Abstract Chemistry is in a period of change,from an era focused on molecules and reactions,to one in which manipulations of CHANGE systems of molecules and reactions will be essential parts controlling larger systems.This Essay traces paths from the past to possible futures. The End of One Era and the Beginning of Another --Whitesides,G.M.(2015),Reinventing Chemistry.Angew.Chem.Int.Ed.,54:3196-3209. (德国应用化学)

The Future Mission of Chemistry？ ---Whitesides, G. M. (2015), Reinventing Chemistry. Angew. Chem. Int. Ed., 54: 3196–3209. （德国应用化学） The chemistry must expand its mission from “molecules,” to “everything that involves molecules

The future mission of Chemistry? 什么是化学？ 认识物质中的分子并制造分子？ 化学使命？ 必须由《分子”拓展到“任何与分子相关的事物”上。 有机化学使命？ 由“有机分子”拓展到“任何与有机分子相关的事物”上

---Whitesides, G. M. (2015), Reinventing Chemistry. Angew. Chem. Int. Ed., 54: 3196–3209. （德国 应用化学） 化学使命？ 必须由“分子”拓展到“任何与分子相关的事物”上。 The Future Mission of Chemistry？ 有机化学使命？ 由“有机分子”拓展到“任何与有机分子相关的事物”上。 什么是化学？ ？ 认识物质中的分子并制造分子？

WHAT will we learn from it? 1.Basic Concepts Thoeries 2.Basic Structures of OMs (3D) 3.Reactions,and Fuctions

WHAT will we learn from it? 1.Basic Concepts & Thoeries 2.Basic Structures of OMs（3D） 3.Reactions, and Fuctions