西北农林科技大学：《有机化学 Organic chemistry》课程PPT教学课件（2017）McMurry OCB 3Ed Chapter 00 Introduction to the course

Organic Chemistry with BiologicalApplications,3rEdition John McMurry ORGANIC CHEMISTRY For Undergraduates in Biological Science By Junru Wang College of Chemistry and Pharmacy Room C206,Science Building Tel:87092829(0);Email:wangjr07@163.com

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com ORGANIC CHEMISTRY For Undergraduates in Biological Science Organic Chemistry with Biological Applications, 3 rd Edition John McMurry

Organic Chemistry with BiologicalApplications,3rEdition John McMurry 4 Qs 1.What Is Organic Chemistry? 2.What Will We Learn From It? 3.How To Study? 4.What Is Your Goal? By Junru Wang College of Chemistry and Pharmacy Room C206,Science Building Tel:87092829(0);Email:wangjr07@163.com

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com Organic Chemistry with Biological Applications, 3 rd Edition John McMurry 4 Qs : 1.What Is Organic Chemistry? 2.What Will We Learn From It? 3.How To Study? 4.What Is Your Goal?

http://www.nature.com/nature/journal/v32/n814/abs/032099a0.html p-BdX 文件何编餐日查收夫A工具D帮助州 Nature32,99-100(04June1885)doi:10.1038/032099a0 a■0■0■■■a■■■■1 An Introduction to the Study of the Compounds of Carbon;of,Organic Chemistry 1a■■■a■■■a■a■a■■口 science.ine student wno pegins tne stuay or tne carpon Web focuses compounds has to suffer many things from the text-books.Some ☒Send to a friend of them present him with dry bones in the shape of isolated facts Podcasts and bold assertions regarding structural formulae and the linking Rights and permission Videos of atoms.Others lead him into speculations which he is unprepared to follow;he makes little flights into these and comes Order commercial reprints News Specials back fancying he is a chemist.Other books(there are not many of them)proceed on the true scientific lines;but very frequently their pages are encumbered with too many facts about more or less Journal widely separated compounds,or they deal so much with groups of open innovation information compounds,rather than with typical individual bodies,that the challenges About the journal beginner soon loses his way,becomes perplexed,and is ready to Future Clothes Washing abandon the nursuit Technologv

WHAT is Organic Chemistry? Organic Chemistry is... >the study of the compounds of carbon >the science of carbon compounds >the chemistry of the compounds of carbon >"the chemistry of living things" 基本概念都是围绕碳的特性建立起来的 a Carbocation a Carbon Radical a Carbanion

Organic Chemistry is… ➢the study of the compounds of carbon ➢the science of carbon compounds ➢the chemistry of the compounds of carbon ➢“the chemistry of living things” 基本概念都是围绕碳的特性建立起来的 C+ C· C￾WHAT is Organic Chemistry?

Scientific Revolution Scientific revolution leads to: Safer and more effective medicines Cures for genetic diseases HH CH3 CH3CH2CH=CHCH2CONH ■Increased life span CH3 COONa Improved quality of life 2-Pentenylpenicillin Scientific advances in medicine and biology require an understanding of organic chemistry

By Junru Wang College of Chemistry and Pharmacy Room C206, Science Building Tel: 87092829(O)；Email: wangjr07@163.com Scientific revolution leads to: ◼ Safer and more effective medicines ◼ Cures for genetic diseases ◼ Increased life span ◼ Improved quality of life Scientific advances in medicine and biology require an understanding of organic chemistry. Scientific Revolution 2-Pentenylpenicillin N S CHCH2CONH H H O CH3 CH3 COONa CH3CH2CH

Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol levels 冠状动脉疾病 75%of blood cholesterol (1000 mg each day)is biosynthesized 、 他汀类药物 Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类降血脂药) 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)to mevalonate conversion 3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin(Lipitor)inactivates enzyme that catalyzes HMG- CoA to mevalonate conversion ■阿托伐他汀

Organic and Biological Chemistry in Modern Medicine ▪ Coronary artery disease (CAD) is directly correlated with blood cholesterol levels ▪ 75% of blood cholesterol (1000 mg each day) is biosynthesized ▪ Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels ▪ 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion ▪ Crucial step in biosynthesis of cholesterol ▪ Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG￾CoA to mevalonate conversion ▪ 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）

H3C OH H3C OH CH3 02C C SCoA OH HO 3-Hydroxy-3-methyl- Mevalonate Cholesterol glutaryl coenzyme A (HMG-CoA) K692 K691 HO. c02 Lo6 OH H .0 R556 R590 3.2 CH3 27 H752 S684 L562 K735 CH3 0L853 V683 L967 1850 R508 Atorvastatin(Lipitor)

The future Mission of Chemistry? Angewandte GDCh Ajoumal of the Chemie Deutscher Chemiker Explore this journal Volume 54,Issue 11 Essay March 9,2015 Pages 3196-3209 Reinventing Chemistry Prof.George M.Whitesides The chemistry must expand its Angewang托 First published:12 February 2015 Full publication hist mission from "molecules,"to DOI:10.1002/anie.201410884 View/save citation "everything that involves Cited by:25 articles Citation tool molecules." View issue TOC Special Issue 150 Years of BASF Abstract Chemistry is in a period of change,from an era focused or molecules and reactions,to one in which manipulations of CHANGE systems of molecules and reactions will be essential parts controlling larger systems.This Essay traces paths from the past to possible futures. The End of One Era and the Beginning of Another ---Whitesides,G.M.(2015),Reinventing Chemistry.Angew.Chem.Int.Ed.,54:3196-3209. (德国应用化学)

The Future Mission of Chemistry？ ---Whitesides, G. M. (2015), Reinventing Chemistry. Angew. Chem. Int. Ed., 54: 3196–3209. （德国应用化学） The chemistry must expand its mission from “molecules,”to “everything that involves molecules

WHAT will we learn from it? 1.Basic Concepts Thoeries 2.Basic Structures of OMs (3D) 3.Reactions,and Fuctions

WHAT will we learn from it? 1.Basic Concepts & Thoeries 2.Basic Structures of OMs（3D） 3.Reactions, and Fuctions

JOHN MCMURRY ORGANIC Text books CHEMISTRY John McMurry By John McMurry (2017-) ·Each chapter is enhanced by biological examples throughout. Organic Chemistry WHY THIS CHAPTER? withBiological Applications a brief introduction,why it is important and how Organic Chemistry it relates to biological chemistry. ◆SOMETHING EXTRA essays end each chapter and tie the Organic Chemistry chapter content to relevant real-world material

Text books By John McMurry （2017- ） •Each chapter is enhanced by biological examples throughout. •WHY THIS CHAPTER? a brief introduction, why it is important and how it relates to biological chemistry. •SOMETHING EXTRA essays end each chapter and tie the chapter content to relevant real-world material