西北农林科技大学：《有机化学 Organic chemistry》课程教学课件（2012）Chapter 20 Amines

目 花华院 Organic Chemistry,6th Edition L.G.Wade,Jr. Chapter 20 Amines By Junru Wang Email:wangjr07@163.com

By Junru Wang Email: wangjr07@163.com Chapter 20 Amines Organic Chemistry, 6th Edition L. G. Wade, Jr

Organic compounds of nitrogen N >-C,H,O-C=0,-CHO,-COOH -CO-Y >一N,一P,一S >一 Organic compounds of nitrogen N ●蛋白质，多肽 ●氨杂环（生物碱， 核酸等) ●酰胺 ●硝基化合物 ●胺 ● ●重氮化合物 ●偶氮氨化合物

Organic compounds of nitrogen N  －C,H,O －C=O，－CHO，－COOH －CO-Y  －N, －P, － S  －Organic compounds of nitrogen N 蛋白质，多肽 氮杂环（生物碱，核酸等） 酰胺 硝基化合物  胺  腈 重氮化合物 偶氮化合物

0特林 Content 样华院 ■Introduction ■Properties Of Amines ■Preparation ■Reactions Of Amines ●As nucleophile >Alkylation;Acylation;Sulfonation ●Hofmann Elimination oReaction with Nitrous Acid ●Oxidation of Amines ●Diazonium salts

Content Introduction Properties Of Amines Preparation Reactions Of Amines As nucleophile Alkylation; Acylation; Sulfonation Hofmann Elimination Reaction with Nitrous Acid Oxidation of Amines Diazonium salts

Sec 1 Introduction 司秋球不精我大好 华院 Biologically Active Amines Neurotransmitters:dopamine ■Bioregulators:epinephrine肾上腺素 ■Vitamins:niacin(烟酸)，B6 Alkaloids:nicotine,morphine,cocaine ■Amino acids CH3 O CH2CH2NH, OCH3 0 H O-C-Ph CH:O OCH3 H OCH3 OH CH. OH H cocaine nicotine mescaline morphine in coca leaves in tobacco in peyote cactus in opium poppies Copyright 2010 Pearson Prentice Hall,Inc

Sec 1 Introduction Biologically Active Amines Neurotransmitters: dopamine Bioregulators: epinephrine肾上腺素 Vitamins: niacin(烟酸), B6 Alkaloids: nicotine, morphine, cocaine Amino acids

Well-Known Amines Adrenaline肾上腺素 Caffeine ·anti-asthma 哮喘 Cocaine Heme Codeine ·O2 transporter Heroin Quinine ·anti-malaria Mescaline Serotonin Morphine ·neurotransmitter Nicotine

Well-Known Amines Well-Known Amines Adrenaline • anti-asthma Heme • O2 transporter Quinine • anti-malaria Serotonin • neurotransmitter Adrenaline • anti-asthma Heme • O2 transporter Quinine • anti-malaria Serotonin • neurotransmitter Caffeine Cocaine Codeine Heroin Mescaline Morphine Nicotine Caffeine Cocaine Codeine Heroin Mescaline Morphine Nicotine 肾上腺素 抗哮喘

Biologically Active Amines Physiologically active nitrogen-containing compounds Obtained from plants ■Jsed as anesthetics, antidepressants,and stimulants ■Many are addictive

Biologically Active Amines Physiologically active nitrogen-containing compounds Obtained from plants Used as anesthetics, antidepressants, and stimulants Many are addictive

Morphine: 0不动大 The sure cure for teething babies ★s.师Qws SOOTHING SYRUP BLDAT

Morphine: The sure cure for teething babies 抚慰的糖浆

Some Examples: 院 H.jH Amphetamine (安非他明) a1° amine used as a central nervous system stimulant in the treatment of certain conditions,such as narcolepsy and depression

Some Examples: Amphetamine (安非他明) a 1 ° amine N H H used as a central nervous system stimulant in the treatment of certain conditions, such as narcolepsy and depression

目写 Some Examples: coniine毒芹碱 a2°amine Poison-Hemlock (芹叶钩吻)Conium maculatum L

Some Examples: N H coniine a 2 ° amine Poison-Hemlock (芹叶钩吻 )Conium maculatum L. 毒芹碱

Some Examples: Cocaine a3°amine CO2CH3

Some Examples: N CH 3 CO 2CH 3 O Ph O Cocaine a 3 ° amine