西北农林科技大学：《有机化学 Organic chemistry》课程PPT教学课件（2013）Chapter 20 Amines

自秋转大好 Organic Chemistry,6th Edition L.G.Wade,Jr. Chapter 20 Amines http://www.study-organic-chemistry.com/ By Junru Wang Email:wangjr07@163.com

By Junru Wang Email: wangjr07@163.com Chapter 20 Amines Organic Chemistry, 6th Edition L. G. Wade, Jr. http://www.study-organic-chemistry.com/

Organic compounds of nitrogen N >-C,H,O -C=0,-CHO,-COOH -CO-Y >-N,-P,-S >-Organic compounds of nitrogen N ●蛋白质，多肽 ●氨杂环（生物碱，核酸等） ●酰胺 ●硝基化合物 RNO2,RC=N,RCH=N-OH,RCH=NNH2, ●胺 RCH-NHCNH2 RCNH2,H2NCNH2 ●重氨化合物 RNH2 ●偶氨化合物 〉○C=N

Organic compounds of nitrogen N ➢－C,H,O －C=O，－CHO，－COOH －CO-Y ➢－N,－P,－S ➢－Organic compounds of nitrogen N ⚫蛋白质，多肽 ⚫氮杂环（生物碱，核酸等） ⚫酰胺 ⚫硝基化合物 ⚫胺 ⚫腈 ⚫重氮化合物 ⚫偶氮化合物 RNO2, RC N, RCH N OH, RCH NNH2, RCH NHCNH2 RCNH2, H2NCNH2 O O O RNH2 N N N N

自秋转大好 Content 花串院 ■Introduction ■Properties Of Amines Preparation ■Reactions Of Amines ●As nucleophile >Alkylation;Acylation;Sulfonation ●Hofmann Elimination .Reaction with Nitrous Acid ●Oxidation of Amines ●Diazonium salts

Content ◼Introduction ◼Properties Of Amines ◼Preparation ◼Reactions Of Amines ⚫As nucleophile ➢Alkylation; Acylation; Sulfonation ⚫Hofmann Elimination ⚫Reaction with Nitrous Acid ⚫Oxidation of Amines ⚫Diazonium salts

Sec 1 Introduction 自秋转达对 院 Biologically Active Amines Neurotransmitters:dopamine ■Bioregulators:epinephrine肾上腺素 ■Vitamins:niacin(烟酸)，B6 Alkaloids:nicotine,morphine,cocaine ■Amino acids CH3 CH2CH2NH2 CH C-OCH3 H O一C一Ph CH3O OCH3 H OCH3 OH OH H cocaine nicotine mescaline morphine in coca leaves in tobacco in peyote cactus in opium poppies Copyright2010 Pearson Prentice Hall,Inc

Sec 1 Introduction Biologically Active Amines ◼Neurotransmitters: dopamine ◼Bioregulators: epinephrine肾上腺素 ◼Vitamins: niacin(烟酸), B6 ◼Alkaloids: nicotine, morphine, cocaine ◼Amino acids

Well-Known Amines Adrenaline肾上腺素 Caffeine ·anti-asthma 哮喘 Cocaine Heme Codeine ·O2 transporter Heroin Quinine ·anti-malaria Mescaline Serotonin Morphine ·neurotransmitter Nicotine

Well-Known Amines Adrenaline • anti-asthma Heme • O2 transporter Quinine • anti-malaria Serotonin • neurotransmitter Caffeine Cocaine Codeine Heroin Mescaline Morphine Nicotine 肾上腺素 抗哮喘

Biologically Active Amines Physiologically active nitrogen-containing compounds ■Obtained from plants ■Used as anesthetics, antidepressants,and stimulants ■Many are addictive

Biologically Active Amines ◼Physiologically active nitrogen-containing compounds ◼Obtained from plants ◼Used as anesthetics, antidepressants, and stimulants ◼Many are addictive

Morphine: 自秋标 常单院 The sure cure for teething babies rWislows SOOTHING SYRUP r a0PE7元

Morphine: The sure cure for teething babies 抚慰的糖浆

自标精对 Some Examples: 人 Amphetamine (安非他明) a1°amine used as a central nervous system stimulant in the treatment of certain conditions,such as narcolepsy and depression

Some Examples: Amphetamine (安非他明) a 1° amine N H H used as a central nervous system stimulant in the treatment of certain conditions, such as narcolepsy and depression

自秋转大好 Some Examples: 花华流 H coniine毒芹碱 a2°amine Poison-Hemlock (芹叶钩吻)Conium maculatum L

Some Examples: N H coniine a 2° amine Poison-Hemlock (芹叶钩吻)Conium maculatum L. 毒芹碱

Some Examples: Cocaine a3°amine CO2CH3 h

Some Examples: N CH3 CO2CH3 O Ph O Cocaine a 3° amine