《慢性动脉血压的调节》讲义

慢性动脉血压的调节 2005.1.5

慢性动脉血压的调节 2005.1.5

本幻灯是生理学系为本科生的一次讲课的课件讲解了 两个问题:慢性动脉血压调节和冠状动每循环的特点。由 于动脉血压的慢性调节主要和肾脏的功能有关,因此放在 学生学完生理科以后讲解。本课件重点讲解的是慢性动脉 血压的调节。 慢性动脉血压的调节与临床上高血压病的形成有密切的 关系,应当作为我们的重点讲课内容。在我们过去的讲课 和教材中都很少提及。我们计划今年内将就这一问题制作 个录像,放到网上交流。本课件是在录像完成前的一次 交流

本幻灯是生理学系为本科生的一次讲课的课件,讲解了 两个问题：慢性动脉血压调节和冠状动每循环的特点。由 于动脉血压的慢性调节主要和肾脏的功能有关，因此放在 学生学完生理科以后讲解。本课件重点讲解的是慢性动脉 血压的调节。 慢性动脉血压的调节与临床上高血压病的形成有密切的 关系，应当作为我们的重点讲课内容。在我们过去的讲课 和教材中都很少提及。我们计划今年内将就这一问题制作 一个录像，放到网上交流。本课件是在录像完成前的一次 交流

Long-term regulation of arterial blood pressure

Long-term regulation of arterial blood pressure (I)

I Three mechanisms for the regulation (1 those that react rapidly within seconds or minutes 2 those that respond over an intermediate time period minutes or hours, those that provide long-term arterial pressure regulation, days, months, and years

I. Three mechanisms for the regulation: ① those that react rapidly, within seconds or minutes; ② those that respond over an intermediate time period, minutes or hours; ③those that provide long-term arterial pressure regulation, days, months, and years

Rapid phase (baroreceptor feedback mechanism(baroreceptor reflex)(carotid sinus, aorta) 2 the chemoreceptor mechanism(chemoreceptor reflex)(carotid body, aortic body) central nervous system ischemic mechanisms 160 858 Reduction of blood supply 16’32 Time after the treatment CNS ischemic response

Rapid phase: ① baroreceptor feedback mechanism (baroreceptor reflex) (carotid sinus, aorta) ② the chemoreceptor mechanism (chemoreceptor reflex) (carotid body, aortic body) ③ central nervous system ischemic mechanisms

Intermediate phase (the rennin-angiotensin vasoconstrictor mechanism 2shift of fluid through the tissue capillary walls in and out of the circulation to readjust the blood volume as needed 3stress-relaxation of the vasculature Delayed compliance Effect on the intravascular pressure oT injecting a small volume of blood into E500 a venous segment and a few minutes later removing extrablood intusion of blood the excess blood 2 demonstrating the principle of delayed compliance Minutes

Intermediate phase ①the rennin-angiotensin vasocontstrictor mechanism; ②shift of fluid through the tissue capillary walls in and out of the circulation to readjust the blood volume as needed. ③stress-relaxation of the vasculature; Effect on the intravascular pressure of injecting a small volume of blood into a venous segment and a few minutes later removing the excess blood, demonstrating the principle of delayed compliance

Long-term phase The renal-body fluid pressure control mechanism this mechanism can eventually return the arterial pressure all the way back, not merely partway back, to the pressure level that provides normal output of salt and water by the kidneys Days. Weeks and years kidneys

Long-term phase mechanism: this mechanism can eventually return the arterial pressure all the way back, not merely partway back, to the pressure level that provides normal output of salt and water by the kidneys The renal-body fluid pressure control ----kidneys ----------Days. Weeks and years

II. Knowledge involved in long-term pressure regulation

II. Knowledge involved in long-term pressure regulation

PIP2=Qr P2=0 2 P=QR Arterial blood pressure is the product of cardiac output and peripheral resistance Mean arterial blood pressure

P1 - P2 = QR P2 = 0 P= QR Arterial blood pressure is the product of cardiac output and peripheral resistance. Mean arterial blood pressure

V Arterial end Venous end +30 Capillary pressure +12 25 Plasma colloid osmotic pressure -25 +15-Colloid osmotic pressure of the+15 interstitial fluid pressure 10- Interstitial fluid pressure-10 8 Effect 10 Effect filltration filltration Capillary p ressure pressure Intersti fluid Lymphatic capilla

Lymphatic capillary Cell A V Capillary