武汉大学生命科学学院：《分子生物学》（英文版）Part II：Maintenance of the Genome CHAPTER 9 The mutability and repair of DNA

Welcome to My Molecular biology Class @或博共字 Wuhan University

Welcome to My Molecular Biology Class

Molecular biology of the Gene 5/E - Watson et al. ( 2004) Part l: chemistry and genetics Part l: Maintenance of the Genome Part l: Expression of the Genome Part IV: Regulation Part v: Methods 3/2205 刻博来字 Wuhan Universit

Molecular Biology of the Gene, 5/E --- Watson et al. (2004) Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/22/05

Part ll: Maintenance of the genome Dedicated to the structure of DNa and the processes that propagate, maintain and alter it from one cell generation to the next @博共字 Wuhan University

Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next

Ch 6: The structures of dna and rna Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA 3/2205

Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA 3/22/05

Teaching arrangement Lecture 1 (1)Introduction to DNA alterations and dna mutations (2) Replication errors and mismatch repair. Lecture 2: (1 Review replication errors and mismatch repair

Teaching arrangement: Lecture 1: (1) Introduction to DNA alterations and DNA mutations (2) Replication errors and mismatch repair. Lecture 2: (1) Review replication errors and mismatch repair;

Different changes of DNA behavior re- address(行为矫正) Chapte8: Mutation(突变) is bad (death and unhealthy y which needs to be repaired Chapter9: Recombination(重组) is good (diversity in a species beautiful), which is promoted Chapter10: Transposition(转座) is not bad because it is not repaired(benefit?)

Different changes of DNA -behavior re-address (行为矫正） ◼ Chapter 8: Mutation (突变) is bad (death and unhealthy), which needs to be repaired ◼ Chapter 9: Recombination (重组) is good (diversity in a species￾beautiful), which is promoted ◼ Chapter 10: Transposition (转座) is not bad, because it is not repaired. (benefit?)

The consequence of high rates of mutation ■ Mutation in germ line〔生殖细胞) would destroy the species Mutation in soma(体细胞) would destroy the individual Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms, Keeping the error rate as low as 10-10 is so expensive

The consequence of high rates of mutation ◼ Mutation in germ line (生殖细胞) would destroy the species ◼ Mutation in soma (体细胞) would destroy the individual. Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms. Keeping the error rate as low as 10-10 is so expensive

Build up a serious attitude to sciencell! I absolutely do not agree with Waston et al. at the points described 3rd 4th paragraphs on page 235 1. What are the more reasonable explanations for the 10-10 mutation frequency in living organisms? 2. What are the evidences that such a low mutation rate can drive the evolvement of a new species if the cell changes are known harmful?

Build up a serious attitude to science!!! I absolutely do not agree with Waston et al. at the points described 3rd & 4th paragraphs on page 235 1. What are the more reasonable explanations for the 10-10 mutation frequency in living organisms? 2. What are the evidences that such a low mutation rate can drive the evolvement of a new species if the cell changes are known harmful?

Listen to the nature Mutation is not good and is naturally repaired thus it could not be responsible for biodiversity. Recombination is good and naturally promoted; it is responsible for diversity inside of species. Transposition is different from mutation and recombination because (1 producing mechanism is different; (2)no mechanism to correct it; 3) existing in nature in a well-controlled manner(1025). Not repaired but controlled

Listen to the nature ◼ Mutation is not good and is naturally repaired, thus it could not be responsible for biodiversity. ◼ Recombination is good and naturally promoted; it is responsible for diversity inside of species. ◼ Transposition is different from mutation and recombination because (1) producing mechanism is different; (2) no mechanism to correct it; (3) existing in nature in a well-controlled manner (10-5). Not repaired but controlled

● Molecular Biology course CHAPTER 9: The mutability and repair of dna 1. Replication errors and their repair 2. DNA damage 3. Repair of DNA damage @劣博字 ht o 2004 Pearson Education, Inc. publishing as benjamin Cummin Wuhan Universit

CHAPTER 9: The mutability and repair of DNA •Molecular Biology Course 1. Replication errors and their repair 2. DNA damage 3. Repair of DNA damage