武汉大学生命科学学院：《分子生物学》（英文版）Part II：Maintenance of the Genome CHAPTER 6 The structures of DNA and RNA

Molecular Biology of the Gene 5/E - Watson et al.( 2004) Part l: Chemistry and Genetics Part e: maintenance of the genome Part lll: Expression of the Genome Part IV: Requlation Part V: Methods 肃溪字 Wuhan Universit

Molecular Biology of the Gene, 5/E --- Watson et al. (2004) Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods

Part ll: Maintenance of the genome Dedicated to the structure of DNA and the processes that propagate传递), maintain(保持 and alter(改变 t from one cel generation to the next

Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate (传递), maintain (保持) and alter (改变) it from one cell generation to the next

Maintenance of the genome Ch 6: The structures of dNA and rNa Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA PROPAGAT AINTAIN Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA ALTER

Maintenance of the Genome Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA PROPAGATE & MAINTAIN ALTER

CHAPTER 6 The structures of dNA and rna How do the structures of dna and rna account for their functions?

CHAPTER 6 The Structures of DNA and RNA How do the structures of DNA and RNA account for their functions?

OUTLINE 1 DNA Structure 2. DNA Topology 3.RNA Structure

OUTLINE 1.DNA Structure 2.DNA Topology 3.RNA Structure

DNA STRUCTURE Structure: two polynucleotide chains are twisting around each other in the form of a double helix

DNA STRUCTURE Structure: two polynucleotide chains are twisting around each other in the form of a double helix

Schematic model Space-filling model hydrogen bond waongoe base 12A sugar.phasphate minor(1.2 nm) nadone groove "E2 22A major(2.2) groove A 3 5 H o Cn phosphate C andN P 20 A(2 nm) cster chain in bases

Schematic model Space-filling model

DNA is composed of polynucleotide chains Nucleoside nucleotide the fundamental building block of dna

DNA STRUCTURE ( ) 1 DNA is composed of polynucleotide chains Nucleoside & Nucleotide, the fundamental building block of DNA

Nucleoside 2-deoxyribose A 5 O—P—OH"HOCH OH base phosphoric acid 钻〓〓〓〓〓〓〓〓百〓〓〓〓〓〓〓〓〓〓〓〓〓〓百〓〓〓〓〓〓〓〓〓孟〓〓〓百〓百〓百孟百百百a孟 HO phosphoester bond N H HO glycosidic bond nucleotide(dAMP Copyright o 2004 Pearson Education, Inc, publishing as Benjamin Cummings

glycosidic bond phosphoester bond Nucleoside

TaBlE 6-1 Adenine and Related Compounds Base Nucleoside Nucleotide Adenine 2 -deoxyadenosine 2 -deoxyadenosine 5-phosphate Structure NH2 Asymmetric N N 530-P-cH HOCH,O 、 Adenine H OH H OH H 33 Molecular 135.1 251.2 331.2 weight Copyright o 2004 Pearson Education, Inc, publishing as Benjamin Cummings

3’ 5’ Asymmetric