武汉大学生命科学学院：《分子生物学》（英文版）sectionD

Q1. Prokaryotic cell E. coli consists of a single closed-circular DNA molecule of 4.6x 106 bp long. This DNA molecule would be 1.6 mm if the double helix is relaxed please describe what strategies does E. coli use to pack such a long molecules into its nucleoid less than a micrometer (um) in diameter. (20 points) Q2. Please list at least two different types of proteins included in E. coli nucleoid and describe the biological function of these proteins. (10points) Q3. Chromatin is the highly ordered dNA-protein complex which makes up the eukayotic chromosomes. >50% of the mass Is protein

Q1. Prokaryotic cell E. coli consists of a single closed-circular DNA molecule of 4.6 x 106 bp long. This DNA molecule would be 1.6 mm if the double helix is relaxed. Please describe what strategies does E. coli use to pack such a long molecules into its nucleoid less than a micrometer (mm) in diameter. (20 points) Q2. Please list at least two different types of proteins included in E. coli nucleoid, and describe the biological function of these proteins. (10points) Q3. Chromatin is the highly ordered DNA-protein complex which makes up the eukayotic chromosomes. >50% of the mass is protein