《儿科学》课程教学资源（授课教案）25 Scarlet Fever

重庆医科大学儿科学教案感染性疾病一猩红热教师：许红梅授课题目TEACHINGTOPICScarlet Fever第几次课TIMES3rd教学方法METHODSClass teaching教学对象OBJECTIVEabroad students in Grade 2007学时:TIME80minutes授课目的PURPOSEStudy Scarlet Fever to know the clinical manifestations and how todiagnose and treat it本课重点EMPHASISTheclinical manifestations,complicationsand treatment本课难点DIFFICULTIESClassification of Streptococci, Virulence of Group A β - hemolyticstreptococci, and Differential diagnosis深化与拓宽Differential diagnosis for Scarlet Fever and Kawasaki DiseaseThe developments英语要求All in EnglishEnglish requirements践性教学安排Clinically, combined with the patients toleam the manifestationsClinical studyand treatment: To discuss the diagnosis and treatment教材TEXTBOOKUSEDYang Xiqjang Chief Editor,《PEDIATRICS》 7th Edion , People'sHealth Publication,2003及参考资料REFERENCES1.胡亚美,江载芳.诸福棠实用儿科学第7版.北京：人民卫生出版社，20022. Behrman RE, Kliegman RM and Jenson HB. Nelson textbook ofpediatrics.16th ed. Science Press, Harcourt Asia, W.B.Saunders, 2001PPT教具TEACHINGAIDS教具PPT教学程序Procedures详细见讲稿主要内容及安排（教学内容详细安排、教学方法的运用、师生活动设计、及时间分Details see the contents and配）arrangementThe contents and Arrangements

重庆医科大学儿科学教案 感染性疾病－猩红热 教师：许红梅 授课题目TEACHING TOPIC Scarlet Fever 第几次课 TIMES 3 rd 教学方法 METHODS Class teaching 教学对象 OBJECTIVE abroad studentsin Grade 2007 学时: TIME 80 minutes 授课目的 PURPOSE Study Scarlet Fever to know the clinical manifestations and how to diagnose and treat it 本课重点 EMPHASIS The clinical manifestations, complications and treatment 本课难点 DIFFICULTIES Classification of Streptococci, Virulence of Group A β - hemolytic streptococci, and Differential diagnosis 深化与拓宽 The developments Differential diagnosis for Scarlet Fever and Kawasaki Disease 英语要求 English requirements All in English 践性教学安排 Clinical study Clinically, combined with the patients to learn the manifestations and treatment; To discuss the diagnosis and treatment. 教材 TEXT BOOK USED Yang Xiqiang Chief Editor，《PEDIATRICS》7th Edition，People’s Health Publication，2003 及参考资料 REFERENCES 1. 胡亚美,江载芳. 诸福棠实用儿科学.第 7 版.北京:人民卫生出版社, 2002 2. Behrman RE, Kliegman RM and Jenson HB. Nelson textbook of pediatrics.16th ed. Science Press, Harcourt Asia, W.B. Saunders, 2001 教具 TEACHING AIDS PPT 教具 PPT 教学程序 Procedures （教学内容详细安排、教学方法的运用、师生活动设计、及时间分 配） 详细见讲稿主要内容及安排 Details see the contents and arrangement The contents and Arrangements

讲稿主要内容及安排meanstimeminScarlet FeverPPTda[Introduction]Scarlet fever is an acute respiratory infection caused by Group Aβ- hemolyticstreptococci(GAS,S.Pywhich produce erythrogenic toxinFever, pharyngitis, scarlet maculae over generalized erythema and desquamation inconvalescent stageImmunopathogenic complications, known as rheumatic fever or glomerulonephritis,mayoccurin2to3wk afterinfectioninsomecases.[Classificationof Streptococci]Streptococci is divided into β-hemolytic streptococci, α-hemolytic streptococci and-hemolytic streptococci Hemolytic pattern.β- hemolytic streptococci are divided into 20 groups alphabetically A to H and K to V.GAS can be subdivided into more than 80 typies of streptococci based on the antigenicaldifferenceof M proteiVirulencece of GroupAβ-hemolytic streptococccompositions of GAS: Hyaluronic Acid Capsule, M protein, Lipoteichoicacid (LTA), Fibronectin-binding protein (F protein)Secretion products of GAS; Erythrogenic toxins (Pyogenic exotoxins), Hemolysin O,Hemolysin s (SLO& SLS),Hyaluronidase, Streptokinase (SK),Steptodornase (SD)[Epidemiology]Infectious sPatients, infective stage:Routes of transmissionPopulation susceptibilityEpidemiologicFeature[Pathophysiology]FlowchartSuppurative inflammation, Toxemia and Post-streptococcal immunopathogenic diseases

讲稿主要内容及安排 means time min Scarlet Fever PPT 80 [Introduction] Scarlet fever is an acute respiratory infection caused by Group A β - hemolytic streptococci (GAS, S. Pyogenes) which produce erythrogenic toxins. Fever, pharyngitis, scarlet maculae over generalized erythema, and desquamation in convalescent stage. Immunopathogenic complications, known as rheumatic fever or glomerulonephritis, may occur in 2 to 3 wk after infection in some cases. 5 [Classification of Streptococci] Streptococci is divided into β- hemolytic streptococci, α- hemolytic streptococci and γ- hemolytic streptococci Hemolytic pattern. β- hemolytic streptococci are divided into 20 groups alphabetically A to H and K to V. GAS can be subdivided into more than 80 typies of streptococci based on the antigenical difference of M protein 8 Virulence of Group A β - hemolytic streptococci ⚫ Structural compositions of GAS: Hyaluronic Acid Capsule, M protein, Lipoteichoic acid (LTA), Fibronectin-binding protein (F protein) Secretion products of GAS: Erythrogenic toxins (Pyogenic exotoxins), Hemolysin O, Hemolysin S (SLO & SLS), Hyaluronidase, Streptokinase (SK), Streptodornase (SD) 8 [Epidemiology] Infectious sources- Patients, infective stage: Routes of transmission Population susceptibility Epidemiologic Feature 5 [Pathophysiology] Suppurative inflammation, Toxemia and Post-streptococcal immunopathogenic diseases Flow chart 5

[Clinm:tiorEmphaIncubation period: 1-7 days from exposure to the onset of disease. The average is 3 daysonclinical1.Typical scarlet fever:Prodromal period,RashperiodandConvalescentperiodmanifestatio2.Mild scarlet feverns of typical3.Streptococcal Toxic Shock-Like Syndrome(STSS)scarlet fever204,Surgical Scarlet Fever and Puerperal Scarlet Fever[Laboratory studies]1. Throat swab culture2.Direct antigen detectionn3. Streptococcal antibody tests4. Complete blood count[Diagnosis]1.Epidemiologic data2.Clinical data33.Laboratory data[Differential Diagnosis]picturesMeasles25Sepsis caused by Erythrogenictoxin-producing strains of Staphylococcus aureusInfectiousMononucleosis4.Drug eruption[Complications]1.Suppurative complicatonsExtension from the pharynxHematogenous dissemination2.Allergic complicationser:the mostt severcomplicationlomerulo-nephrit[Treatment]1.Antibiotics:Penicillin,Erythromycin52.Supportive and symptomatic treatment[Prognosis]3[结课]回顾课堂内容，说明重点要求掌握的内容布置见习的内容和要求

[Clinical manifestations] Incubation period: 1-7 days from exposure to the onset of disease. The average is 3 days 1.Typical scarlet fever: Prodromal period, Rash period and Convalescent period 2.Mild scarlet fever 3.Streptococcal Toxic Shock-Like Syndrome (STSS) 4,Surgical Scarlet Fever and Puerperal Scarlet Fever Emphasis on clinical manifestatio ns of typical scarlet fever 20 [Laboratory studies] 1. Throat swab culture 2. Direct antigen detection 3. Streptococcal antibody tests 4. Complete blood count 5 [Diagnosis] 1.Epidemiologic data 2.Clinical data 3.Laboratory data 3 [Differential Diagnosis] 1. Measles 2. Sepsis caused by Erythrogenic toxin -producing strains of Staphylococcus aureus. 3. Infectious Mononucleosis 4. Drug eruption pictures 5 [Complications] 1.Suppurative complicatons Extension from the pharynx Hematogenous dissemination 2.Allergic complications Rheumatic fever: the most sever complication Glomerulo-nephritis 6 [Treatment] 1. Antibiotics: Penicillin, Erythromycin 2. Supportive and symptomatic treatment 5 [Prognosis] 3 [结课] 回顾课堂内容，说明重点要求掌握的内容 布置见习的内容和要求 2

ReviewQAWhat arethe clinical manifestations oftypical scarletfever?complications of scarlet fever?WhHow to treat scarlet fever?总结及补充修正授课年级总结及修正补充内容备注2005级增加提问2006级增加图片2007级增加图片

Review QA： 1. What are the clinical manifestations of typical scarlet fever? 2. What are the main complications of scarlet fever? 3. How to treat scarlet fever? 总结及补充修正 授课年级 总结及修正补充内容 备注 2005 级 增加提问 2006 级 增加图片 2007 级 增加图片