浙江大学医学院：心血管系统疾病（PPT课件）Diseases of the cardiovascular system Diseases of the cardiovascular system

Diseases of the cardiovascular system Malign Department of Pathology and Pathophysiology School of Medicine, Zhejiang University 3

Diseases of the cardiovascular system Maliqin Department of Pathology and Pathophysiology School of Medicine, Zhejiang University

atherosclerosIs(AS 1. etiology and pathogenesis Risk factors 6o Hyperlipemia: increased LDL, TG, VLDL, apoB, Lp(a) decreased HDL, apoA-l Hypertension %s Cigarette smoking &o Elevated blood sugar levels ☆ The other factors

atherosclerosis(AS) 1. etiology and pathogenesis Risk factors ❖ Hyperlipemia:increased LDL, TG, VLDL, apoB,Lp(a) decreased HDL,apoA-I ❖ Hypertension ❖ Cigarette smoking ❖ Elevated blood sugar levels ❖ The other factors

pathogenesis Theory of inflammatory response to Injury . The injury of the endothelium s The accumulation of lipid The infiltration of macrophages %o The proliferation of SMc

pathogenesis --Theory of inflammatory response to injury ❖The injury of the endothelium ❖The accumulation of lipid ❖The infiltration of macrophages ❖The proliferation of SMC

2. morphology Predilection for large arteries and medium-sized arteries Basic lesion o Fatty streak Accumulated lipid, foam cell o Fibrous plaque- Fibrous cap

2.morphology Predilection for large arteries and medium-sized arteries Basic lesion ❖Fatty streak Accumulated lipid, foam cell ❖Fibrous plaque-- Fibrous cap

黄色脂 质条纹 5 c Fig 3. 1. Lipidosis of the aorta. W

黄色脂 质条纹

2. morphology Predilection for large arteries and medium-sized arteries Basic lesion 冷 Fatty streak Accumulated lipid, foam cell Fibrous plaque- Fibrous cap

2.morphology Predilection for large arteries and medium-sized arteries Basic lesion ❖Fatty streak Accumulated lipid, foam cell ❖Fibrous plaque-- Fibrous cap

正常主动脉 动脉粥样硬化的纤维斑块病变 ( Fig 3-5. Normal and arteriosclerotic aorta

正常主动脉 动脉粥样硬化的纤维斑块病变

动脉管壁一侧明显增厚

动脉管壁一侧明显增厚

Atheromatous plaque ( atheroma) Fibrous cap cholesterol crystal necrotic debris foam cell calcification neovascular formation

•Atheromatous plaque (atheroma) Fibrous cap cholesterol crystal necnotic debris foam cell calcification neovascular formation

atheroma H 1 cm- Fig3.2. Atheroma of the aorta

atheroma