《微生物学 Microbiology》课程PPT教学课件（英文版）microbial diseases of the cardiovascalar and lymphatic systems 3/3

Chapter 23,part C Microbial Diseases of the Cardiovascular and Lymphatic Systems

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 23, part C Microbial Diseases of the Cardiovascular and Lymphatic Systems

Burkitt's Lymphoma Nasopharyngeal carcinoma Epstein-Barr virus (Human herpesvirus 4) Cancer in immunosuppressed individuals,and malaria and AlDS patients

• Nasopharyngeal carcinoma • Epstein-Barr virus (Human herpesvirus 4) • Cancer in immunosuppressed individuals, and malaria and AIDS patients Burkitt’s Lymphoma

Infectious Mononucleosis Epstein-Barr virus (Human herpesvirus 4) Childhood infections are asymptomatic Transmitted via saliva Characterized by proliferation of monocytes

• Epstein-Barr virus (Human herpesvirus 4) • Childhood infections are asymptomatic • Transmitted via saliva • Characterized by proliferation of monocytes Infectious Mononucleosis

Infectious Mononucleosis 100 EB virus 80 CMV 60 40 TOXO 20 0 0.5-2 3-5 6-10 11-15 16-20 21-25 26-50 >50 Age(yr) Figure 23.20

Infectious Mononucleosis Figure 23.20

Cytomegalic Inclusion Disease Cytomegalovirus (Human herpesvirus 5) Infected cells swell (cyto-,mega-) Latent in white blood cells May be asymptomatic or mild Transmitted across the placenta,may cause mental retardation Transmitted sexually,by blood,or by transplanted tissue

• Cytomegalovirus (Human herpesvirus 5) • Infected cells swell (cyto-, mega-) • Latent in white blood cells • May be asymptomatic or mild • Transmitted across the placenta, may cause mental retardation • Transmitted sexually, by blood, or by transplanted tissue Cytomegalic Inclusion Disease

Viral Hemorrhagic Fevers Classic Yellow fever Flavivirus Aedes aegypti Monkeys Dengue DHF Flavivirus A.aegypti No known A.albopictus reservoir Emerging Marbug Filovirus Monkeys(?) Ebola Filovirus Monkeys(?) Lassa fever Arenavirus Rodents Argentine hemorrhagic Arenavirus Rodents fever Bolivian hemorrhagic Arenavirus Rodents fever Hantavirus pulmonary Hantavirus Rodents syndrome

Viral Hemorrhagic Fevers Classic Yellow fever Flavivirus Aedes aegypti Monkeys Dengue & DHF Flavivirus • A. aegypti • A. albopictus No known reservoir Emerging Marbug Filovirus • Monkeys (?) Ebola Filovirus • Monkeys (?) Lassa fever Arenavirus • Rodents Argentine hemorrhagic fever Arenavirus • Rodents Bolivian hemorrhagic fever Arenavirus • Rodents Hantavirus pulmonary syndrome Hantavirus • Rodents

Ebola Virus Figure 23.21

Ebola Virus Figure 23.21

American Trypanosomiasis (Chagas'Disease) 。Trypanosoma cruzi 。Reservoir ·Rodents, opossums, armadillos 。Vector 。Reduviid bug (d)Kissing bug Figure23.22,12.33d

• Trypanosoma cruzi • Reservoir • Rodents, opossums, armadillos • Vector • Reduviid bug American Trypanosomiasis (Chagas’Disease) Figure 23.22, 12.33d

Toxoplasmosis Toxoplasma Cat ingests bradyzoites in tissue cysts in gondii animals,usually mice. Bradyzoites in tissue cyst (usually 10 to 100um Tachyzoites in diameter) (2 x 7um) ①Immature oocyst If humans eat Definitive host is shed in undercooked cat feces. meat containing tissue cysts,they may become Immature infected. oocyst M Sporozoites from ingested oocysts Sporogony invade animal tissue and develop into bradyzoites within tissue cysts,or into tissue-invading tachyzoites. Mature oocyst If a pregnant (10-12um) woman accidentally ingests oocysts (contacted when Intermediate changing a cat litter host box),prenatal infection of the fetus may occur Sporocyst Sporozoite Mature oocyst develops by sporogony and contains two Oocysts can infect many hosts,including mice sporocysts,each with four domestic animals,and humans,via ingestion. infective sporozoites. Figure 23.23

• Toxoplasma gondii Toxoplasmosis Figure 23.23

Malaria Plasmodium vivax,P.ovale,P malariae,P.falciparum 。Anopheles mosquito (b)Anopheles 12.31b

• Plasmodium vivax, P. ovale, P malariae, P. falciparum • Anopheles mosquito Malaria 12.31b