《微生物学 Microbiology》课程PPT教学课件（英文版）microbial diseases of the respiratory system 3/3

Chapter 24,part C Microbial Diseases of the Respiratory System

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 24, part C Microbial Diseases of the Respiratory System

Mycoplasmal Pneumonia 。 Mycoplasma pneumoniae: pleomorphic,wall- less bacteria 。 Also called primary atypical pneumonia and walking pneumonia 。Common in children and young adults 。Diagnosis by PCR or by IgM antibodies Figure 24.14

Mycoplasmal Pneumonia Figure 24.14 • Mycoplasma pneumoniae: pleomorphic, wall￾less bacteria • Also called primary atypical pneumonia and walking pneumonia • Common in children and young adults • Diagnosis by PCR or by IgM antibodies

Mycoplasmal Pneumonia Figure 11.19a,b

Mycoplasmal Pneumonia Figure 11.19a, b

Legionellosis Legionella pneumophila:Gram-negative rod L.pneumophila is found in water Transmitted by inhaling aerosols,not transmitted from human to human Diagnosis:culturing bacteria Treatment:Erythromycin

• Legionella pneumophila: Gram-negative rod • L. pneumophila is found in water • Transmitted by inhaling aerosols, not transmitted from human to human • Diagnosis: culturing bacteria • Treatment: Erythromycin Legionellosis

Psittacosis (Ornithosis) Chlamydia psittaci:gram-negative intracellular bacterium Transmitted by elementary bodies from bird dropping to humans Reorganizes into reticulate body after being phagocytized Diagnosis:culturing bacteria in eggs or cell culture Treatment:Tetracycline

• Chlamydia psittaci: gram-negative intracellular bacterium • Transmitted by elementary bodies from bird dropping to humans • Reorganizes into reticulate body after being phagocytized • Diagnosis: culturing bacteria in eggs or cell culture • Treatment: Tetracycline Psittacosis (Ornithosis)

Chlamydial Pneumonia Chlamydia pneumoniae Transmitted from human to human ·Diagnosis by FA test Treatment:Tetracycline

• Chlamydia pneumoniae • Transmitted from human to human • Diagnosis by FA test • Treatment: Tetracycline Chlamydial Pneumonia

Q fever Mycoplasma pneumoniae:pleomorphic,wall-less bacteria Also called primary atypical pneumonia and walking pneumonia Common in children and young adults Diagnosis by PCR or by IgM antibodies

Q fever • Mycoplasma pneumoniae: pleomorphic, wall-less bacteria • Also called primary atypical pneumonia and walking pneumonia • Common in children and young adults • Diagnosis by PCR or by IgM antibodies

Q fever (a)Coxiella burnetil gowing in placental cell. (b)This cell has just divided;notice the endospore-like body(E),which is probably responsible for the relative resistance of the organism. Figure 24.15

Q fever Figure 24.15

Viral Pneumonia Viral pneumonia as a complication of influenza, measles,chickenpox Viral etiology suspected if no cause determined Respiratory Syncytial Virus(RSV) Common in infants;4500 deaths annually Causes cell fusion (syncytium)in cell culture ·Symptoms:coughing Diagnosis by serologic test for viruses and antibodies Treatment:Ribavirin

• Viral pneumonia as a complication of influenza, measles, chickenpox • Viral etiology suspected if no cause determined • Respiratory Syncytial Virus (RSV) • Common in infants; 4500 deaths annually • Causes cell fusion (syncytium) in cell culture • Symptoms: coughing • Diagnosis by serologic test for viruses and antibodies • Treatment: Ribavirin Viral Pneumonia

Influenza Chills,fever,headache,muscle aches (no intestinal symptoms) 1%mortality due to secondary bacterial infections Treatment:Amantadine Vaccine for high-risk individuals

• Chills, fever, headache, muscle aches (no intestinal symptoms) • 1% mortality due to secondary bacterial infections • Treatment: Amantadine • Vaccine for high-risk individuals Influenza