《微生物学 Microbiology》课程PPT教学课件（英文版）microbial diseases of the cardiovascalar and lymphatic systems 2/3

Chapter 23,part B Microbial Diseases of the Cardiovascular and Lymphatic Systems

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 23, part B Microbial Diseases of the Cardiovascular and Lymphatic Systems

Biological Weapons 1346 Plague-ridden bodies used by Tartar army against Kaffa 。1925 Plaque-carrying flea bombs used in the Sino-Japanese War ● 1950s U.S.Army spraying of S.marcescens to test weapons dispersal 。1972 International agreement to not possess biological weapons 。1979 B.anthracis weapons plant explosion in the Soviet Union 1984 S.enterica used against the people of The Dalles 。2001 B.anthracis distributed in the U.S

• 1346 Plague-ridden bodies used by Tartar army against Kaffa • 1925 Plaque-carrying flea bombs used in the Sino-Japanese War • 1950s U.S. Army spraying of S. marcescens to test weapons dispersal • 1972 International agreement to not possess biological weapons • 1979 B. anthracis weapons plant explosion in the Soviet Union • 1984 S. enterica used against the people of The Dalles • 2001 B. anthracis distributed in the U.S. Biological Weapons

Biological Weapons Bacteria Viruses Bacillus anthracis "Eradicated"polio and measles Brucella spp Encephalitis viruses Chlamydia psittaci Hermorrhagic fever viruses Clostridium botulinum toxin InfluenzaA(1918 strain) Coxiella burnetti Monkeypox Francisella tularensis Nipah virus Rickettsia prowazekii Small pox Shigella spp. Yellow fever Vibrio cholerae Yersinia pestis

Biological Weapons Bacteria Viruses Bacillus anthracis “Eradicated” polio and measles Brucella spp. Encephalitis viruses Chlamydia psittaci Hermorrhagic fever viruses Clostridium botulinum toxin Influenza A (1918 strain) Coxiella burnetti Monkeypox Francisella tularensis Nipah virus Rickettsia prowazekii Small pox Shigella spp. Yellow fever Vibrio cholerae Yersinia pestis

Gangrene 。Ischemia Loss of blood supply to tissue ·Necrosis 。Death of tissue 。Gangrene ·Death of soft tissue ·Gas gangrene Clostridium perfringens,gram-positive,endospore- forming anaerobic rod,grows in necrotic tissue Treatment includes surgical removal of necrotic tissue and/or hyperbaric chamber

• Ischemia • Loss of blood supply to tissue • Necrosis • Death of tissue • Gangrene • Death of soft tissue • Gas gangrene • Clostridium perfringens, gram-positive, endospore￾forming anaerobic rod, grows in necrotic tissue • Treatment includes surgical removal of necrotic tissue and/or hyperbaric chamber Gangrene

Animal bites and scratches Pasteurella multocida ·Clostridium 。Bacteroides 。Fusobacterium 。Bartonella hensellae ·Cat-scratch disease

• Pasteurella multocida • Clostridium • Bacteroides • Fusobacterium • Bartonella hensellae • Cat-scratch disease Animal bites and scratches

Plague Yersinia pestis,gram-negative rod 。Reservoir Rats,ground squirrels,prairie dogs ·Vector ·Xenopsylla cheopsis 。Bubonic plague Bacterial growth in blood and lymph 。Septicemia plague ·Septic shock 。Pneumonic plague 。Bacteria in the lungs

• Yersinia pestis, gram-negative rod • Reservoir • Rats, ground squirrels, prairie dogs • Vector • Xenopsylla cheopsis • Bubonic plague • Bacterial growth in blood and lymph • Septicemia plague • Septic shock • Pneumonic plague • Bacteria in the lungs Plague

Plague ☐1case 11-15 cases 2-5 cases 16-20 cases 6-10 cases 21 or more Figure 23.10,11

Plague Figure 23.10, 11

Relapsing Fever Borrelia spp.,spirochete 。Reservoir 。Rodents 。Vector 。Ticks Successive relapses are less severe

• Borrelia spp., spirochete • Reservoir • Rodents • Vector • Ticks • Successive relapses are less severe Relapsing Fever

Lyme Disease Borrelia burgdorferi 。Reservoir ·Deer 。Vector 。Ticks

• Borrelia burgdorferi • Reservoir • Deer • Vector • Ticks Lyme Disease

Lyme Disease Female tick Uninfected six-legged larva lays eggs hatches from egg and develops ⑦Adults feed on deer and mate ②Larva feeds on small animal, becoming Year 1-Spring infected Fall and Winter Summer ⑥Nymph develops into adult tick Summer Fall and Winter Male Female Year 2-Spring Nymph feeds on animal or human, ③Larva is transmitting infection dormant ④Larva develops into eight-legged nymph (a)The tick,Ixodes scapularis,has a two-year life cycle in which it requires three blood meals. The tick is infected by its first blood meal,and can pass on the infection to a human in its second. Figure 23.13a

Lyme Disease Figure 23.13a