安徽医科大学：《组织学与胚胎学》课程教学资源（课件讲稿）Chapter 10 免疫系统 Immune system

Anhui Medical University Chapter10 Immune system Lyu Zhengmei Department of Histology and Embryology, Anhui Medical University

Anhui Medical University Chapter10 Immune system Lyu Zhengmei Department of Histology and Embryology, Anhui Medical University

Anhui Medical University I.General Introduction Function -Defense The human body immune system has the ability to distinguish "self from "non-self,to fight against foreign molecules,and destroy microorganisms,abnormal cells or even cancer cells in own body. Abnormally,the immune system of individual reacts with its own normal body tissues or molecules, causing autoimmune disease

Anhui Medical University Function - Defense The human body immune system has the ability to distinguish “self” from “non-self”, to fight against foreign molecules, and destroy microorganisms, abnormal cells or even cancer cells in own body. Abnormally, the immune system of individual reacts with its own normal body tissues or molecules, causing autoimmune disease. Ⅰ.General Introduction

Anhui Medical University Components of immune system 1.immune cells 2.lymphoid tissue 3.lymphoid organs

Anhui Medical University 1. immune cells 2. lymphoid tissue 3. lymphoid organs Components of immune system

Anhui Medical University Tonsils Internal jugular vein Subclavian vein Thymus over Thoracic duct heart Axillary nodes Thoracic duct- Spleen Large intestine Small intestine Lymphatic vessels Enlarged inguinal nodes Lymphatic vessels Enlarged lymph nodes (due to infected right first toe) Injured right first toe

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Anhui Medical University 1.immune cells lymphocytes Macrophage and MPS antigen presenting cells (APCs) MPS:Mononuclear phagocytic system

Anhui Medical University lymphocytes Macrophage and MPS antigen presenting cells (APCs) 1. immune cells MPS: Mononuclear phagocytic system

Anhui Medical University Lymphocytes T:Thymus dependent lymphocytes B:Bone marrow dependent lymphocytes NK:Natural killer cells

Anhui Medical University Lymphocytes T : Thymus dependent lymphocytes B: Bone marrow dependent lymphocytes NK: Natural killer cells

Anhui Medical University Mononuclear phagocytic system(MPS) MPS has intense phagocytic activity, involving in immune response.The cells of MPS originate from monocyte and distribute throughout the body. Function:phagocytosis

Anhui Medical University MPS has intense phagocytic activity, involving in immune response. The cells of MPS originate from monocyte and distribute throughout the body. Function: phagocytosis Mononuclear phagocytic system (MPS)

Anhui Medical University Cells of MPS Name Distribution Monocyte Blood Macrophage C.T.,lymph node Kupffer cell Liver Dust cell Lung Osteoclast Bone Microglia CNS

Anhui Medical University Name Distribution Monocyte Blood Macrophage C.T., lymph node Kupffer cell Liver Dust cell Lung Osteoclast Bone Microglia CNS Cells of MPS

Anhui Medical University Antigen Antigen presenting cells(APCs) APCs have the capacity to capture the antigens, and digest the protein.The lymphocytes can only recognize the small peptides presented by APCs.In this way,APCs present the antigens to lymphocytes and elicit the immune response. includes macrophages dendritic cells and B lymphocytes

Anhui Medical University APCs have the capacity to capture the antigens, and digest the protein. The lymphocytes can only recognize the small peptides presented by APCs. In this way, APCs present the antigens to lymphocytes and elicit the immune response. includes macrophages , dendritic cells and B lymphocytes . Antigen presenting cells(APCs)

Anhui Medical University Dendritic cells HG8 Dendritic cells include Langerhans cells in epidermis Interdigitating cells in spleen and lymph nodes Follicular dendritic cells in lymphoid nodules Langerhans cell in skin 96091815KyX3:8iaAm Dendritic cells in vitro

Anhui Medical University Dendritic cells include  Langerhans cells in epidermis  Interdigitating cells in spleen and lymph nodes  Follicular dendritic cells in lymphoid nodules  Langerhans cell in skin Dendritic cells in vitro Dendritic cells