浙江大学医学院：《医学史简论 A Brief History of Medicine》课程教学资源（PPT课件）人类与传染病的斗争 Battles to Infectious Diseases（二）

医学史简论(8) a Brief History of Medicine 浙江大学医学院余海 Zhejiang University School of Medicine

医学史简论（8） A Brief History of Medicine 浙江大学医学院 余 海 Zhejiang University School of Medicine

人写作的斗2〗 Battles to infectious Diease(2)

人类与传染病的斗争(2) Battles to Infectious Diseases(2)

Infectious disease in Chinese medicine ●病: disease, ilness, more individually ●疾病预防: Disease prevention ●疫: Epidemic, communicable disease, more population based(瘟疫 plague) ●防疫: Epidemic prevention ●兔疫: Immunity, Vaccination ●疫苗: Vaccine

Infectious disease in Chinese Medicine  病：disease, illness, more individually  疾病预防：Disease prevention  疫：Epidemic, communicable disease, more population based (瘟疫 plague)  防疫：Epidemic prevention  免疫：Immunity, Vaccination  疫苗：Vaccine

How did we win the battles o Identify the pathogens -Germ Theory o Effective therapy -Vaccine and Antibiotics o Prevention and control public health system

How did we win the battles  Identify the pathogens - Germ Theory  Effective therapy – Vaccine and Antibiotics  Prevention and control - Public Health System

Establishment of Germ Theory o De Contagione et Contagiosis Morbis(On infection and infectious diseases, 1546) o He proposed that epidemic diseases are caused by transferable tiny particles or spores"that could transmit infection by direct or indirect contact or even without contact over long distances seeds nfection symptom courses Girolamo fracastoro destroy or 1478-1553 expel seeds

Establishment of Germ Theory  De Contagione et Contagiosis Morbis(On infection and infectious diseases,1546)  He proposed that epidemic diseases are caused by transferable tiny particles or "spores" that could transmit infection by direct or indirect contact or even without contact over long distances. Girolamo Fracastoro 1478-1553

Establishment of Germ Theory A Dutch cloth merchant used new method or grinding and polishing tiny lenses of great curvature which gave magnifications up to 270 diameters First to see and describe bacteria as animalcules Leeuwenhoek /*3Yi became the pioneer of microbIology Antonie van Leeuwenhoek 1632-1723 等动

Establishment of Germ Theory Antonie van Leeuwenhoek 1632-1723 A Dutch cloth merchant used new method for grinding and polishing tiny lenses of great curvature which gave magnifications up to 270 diameters First to see and describe bacteria as animalcules， Leeuwenhoek became the pioneer of microbiology

Establishment of Germ Theory Created germ theory of disease (germ theory vs miasma theory and spontaneous generation) o Created the first vaccine for rabies o Invented pasteurization o Is regarded as one of the three main founders of microbiology, together with Ferdinand 巴斯德1822-1895 Cohn and robert koch Louis pasteur

Establishment of Germ Theory  Created germ theory of disease, (germ theory vs miasma theory and spontaneous generation)  Created the first vaccine for rabies  Invented Pasteurizaion  Is regarded as one of the three main founders of microbiology, together with Ferdinand Cohn and Robert Koch. 巴斯德 1822-1895 Louis Pasteur

Germ Theory vs Spontaneous generation Theory Do not put forward anything that you cannot prove by experimentation Wait 5天 Boil No growth Wait Microbial Boil Break stem growth swan-neck flask experiment

Germ Theory vs Spontaneous Generation Theory "Do not put forward anything that you cannot prove by experimentation" swan-neck flask experiment

Establishment of Germ Theory Heinrich hermann robert koch 1843-1910) ● German physician o Isolating Bacillus anthracis(1877), the tuberculosis bacillus(1882) and the vibrio cholera(1883) o Development of Koch's postulates o He was awarded the nobel prize in Physiology or medicine for his tuberculosis findings in 1905

Establishment of Germ Theory Heinrich Hermann Robert Koch (1843-1910）  German physician  Isolating Bacillus anthracis (1877), the Tuberculosis bacillus (1882) and the Vibrio cholera (1883)  Development of Koch’s postulates  He was awarded the Nobel Prize in Physiology or Medicine for his tuberculosis findings in 1905

Pure culture of bacteria initial econd“ streak innoculation with clean probe Colonies colonies derived from single cell with clean probe

Pure culture of bacteria