复旦大学附属妇产科医院：《妇产科学》课程教学资源（PPT课件讲稿）uterine cancer-revision

Uterine cancer Xi-Shi Liu Obstetrics and Gynecology Hospital Fudan university

Uterine Cancer Xi-Shi Liu Obstetrics and Gynecology Hospital Fudan university

General Description Also called endometrial cancer Endometrial cancer is one of the most common malignancy of female genital tract

General Description • Also called endometrial cancer • Endometrial cancer is one of the most common malignancy of female genital tract

General Description ° A malignant epithelial disease that occurs in endometrial gland of uterus The incidence of endometrial cancer is increasing worldwide in ecent years

General Description • A malignant epithelial disease that occurs in endometrial gland of uterus • The incidence of endometrial cancer is increasing worldwide in recent years

Risk Factors 1. Medical conditions a Diabetes mellitus, hypertension b. Overweight---obesity(excess estrogen as a result of peripheral conversion of adrenally derived androstenedione by aromatization in fat) C Late menopause

Risk Factors 1. Medical conditions a. Diabetes mellitus, hypertension. b. Overweight---obesity (excess estrogen as a result of peripheral conversion of adrenally derived androstenedione by aromatization in fat). c. Late menopause

Risk Factors 2. Some gynecologic diseases Long-term endogenous estrogen exposure polycystic ovary syndrome functioning ovarian tumors anovulating dysfunctional bleeding Infertility, Nulliparity

Risk Factors 2. Some gynecologic diseases ( Long-term endogenous estrogen exposure ) - polycystic ovary syndrome - functioning ovarian tumors - anovulating dysfunctional bleeding - Infertility, Nulliparity

Risk Factors 3. Prolonged Use of estrogen a Prolonged menopausal estrogen replacement therapy without progestogen b. Prolonged use of the antiestrogen tamoxifen for breast cancer

Risk Factors 3. Prolonged Use of estrogen a. Prolonged menopausal estrogen replacement therapy without progestogen. b. Prolonged use of the antiestrogen tamoxifen for breast cancer

Risk Factors 4. Genetic factors and other factors a Endometrial and ovarian cancer are the simultaneously occurring with other genital malignancy reported incidence (14-38%) b. Family history of tumor is higher. (12 28%)

Risk Factors 4. Genetic factors and other factors a. Endometrial and ovarian cancer are the simultaneously occurring with other genital malignancy ,reported incidence (1.4~3.8%). b. Family history of tumor is higher.(12- 28%)

Classification Estrogen dependent and estrogen independent are two different pathogenetic types One with history of exposure to unopposed estrogen(either endogenous or exogenous) Other type with no source of estrogen stimulation of endometrium

Classification • Estrogen dependent and estrogen independent are two different pathogenetic types: -- One with history of exposure to unopposed estrogen (either endogenous or exogenous). -- Other type with no source of estrogen stimulation of endometrium

Five histological subtypes Endometrioid adenocarcinoma Mucinous carcinoma Serous adenocarcinoma Clear cell carcinoma Other rare subtypes

Five histological subtypes • Endometrioid adenocarcinoma • Mucinous carcinoma • Serous adenocarcinoma • Clear cell carcinoma • Other rare subtypes

Five histological subtypes Endometrioid adenocarcinoma · Account for about 80~90% ·We! differentiated Prognosis is better

Five histological subtypes --Endometrioid Adenocarcinoma • Account for about 80~90%. • Well differentiated. • Prognosis is better