上海交通大学医学院：《妇产科学》（双语） 15 OVARIAN CANCER

OVARIAN CANCER Di Wen. M.D.Ph. D

OVARIAN CANCER Di Wen, M.D.,Ph.D

OVARIAN TUMOURS Definition but are commonest between 30 and 60 ge Ovarian tumors may arise at any age 1.Ovarian tumors are particularly liable to be or to become malignant 2.In their early stages they are asymptomatic and painless 3. They may grow to a large size and tend to undergo mechanical complications such as torsion and perforation 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 2 Definition Ovarian tumors may arise at any age, but are commonest between 30 and 60. 1.Ovarian tumors are particularly liable to be or to become malignant. 2.In their early stages they are asymptomatic and painless. 3.They may grow to a large size and tend to undergo mechanical complications such as torsion and perforation. OVARIAN TUMOURS

CARCINOMA OF THE OVARY Definition In developed countries, women have a lifetime risk of developing ovarian cancer of about 1.4%, which is slightly greater than the risk of cervical or endometrial cancers, but well below the 7y average risk of breast cancer 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 3 Definition In developed countries，women have a lifetime risk of developing ovarian cancer of about 1.4%，which is slightly greater than the risk of cervical or endometrial cancers, but well below the 7% average risk of breast cancer． CARCINOMA OF THE OVARY

CARCINOMA OF THE OVARY Risk Factor Genetic factor are sometimes involved as in the Lynch Syndrome of familial breast colorectal and ovarian cancer. Ovulation induction with Clomiphene over more than year carries a 10-fold increased risk of ovarian cancer Long-term oral contraceptive use reduces the incidence of ovarian cancers 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 4 Risk Factor Genetic factor are sometimes involved、 as in the Lynch Syndrome of familial breast colorectal and ovarian cancer．Ovulation induction with Clomiphene over more than year carries a l0-fold increased risk of ovarian cancer, Long-term ora1 contraceptive use reduces the incidence of ovarian cancers． CARCINOMA OF THE OVARY

CARCINOMA OF THEOVARY Incidence Nearly 25% of all ovarian neoplasm are malignant. Approximately 80%0 of them are primary growths of the ovary the remainder being secondary, usually carcinomata 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 5 Incidence Nearly 25% of all ovarian neoplasm are malignant．Approximately 80％ of them are primary growths of the ovary、the remainder being secondary，usually carcinomata． CARCINOMA OF THE OVARY

CARCINOMA OF THE OVARY Primary Carcinoma of the Ovary 80%of all cases of primary carcinoma of the ovary arise in serous or mucinous cysts 2003-10-27 Ovarian cancer 6

2003-10-27 Ovarian Cancer 6 Primary Carcinoma of the Ovary 80％ of all cases of primary carcinoma of the ovary arise in serous or mucinous cysts. CARCINOMA OF THE OVARY

CARCINOMA OF THE OVARY Solid Carcinoma of the Ovary This accounts for 10% of primary carcinoma. It is arise commonly bilateral but one tumor is usually larger than the other. the ovarian shape is retained for a time and there is a well-marked pedicle but soon the tumors become fixed. Secondary deposits occur in the omentum and ascites develops 2003-10-27 Ovarian cancer 7

2003-10-27 Ovarian Cancer 7 Solid Carcinoma of the Ovary This accounts for 10% of primary carcinoma. It is arise commonly bilateral but one tumor is usually larger than the other. The ovarian shape is retained for a time and there is a well-marked pedicle but soon the tumors become fixed. Secondary deposits occur in the omentum and ascites develops. CARCINOMA OF THE OVARY

CLINICAL FEATURES OF OVARIAN TUMOURS Symptoms due to Size Lack of any specific symptoms, ovarian tumors are often large by the time the doctor is consulted 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 8 Symptoms due to Size Lack of any specific symptoms, ovarian tumors are often large by the time the doctor is consulted. CLINICAL FEATURES OF OVARIAN TUMOURS

Menstrual function is seldom upset, and any irregularity is attributed to the patient's ' time of 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 9 Menstrual function is seldom upset, and any irregularity is attributed to the patient’s ‘time of life’

She may have noticed that her clothes are getting tightant attributed this to weight gain or, if the abdominal swelling has coincided with amenorrhea she may believe herself to be pregnant 2003-10-27 Ovarian cancer

2003-10-27 Ovarian Cancer 10 She may have noticed that her clothes are getting tight ant attributed this to weight gain or, if the abdominal swelling has coincided with amenorrhea she may believe herself to be pregnant