上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）Drugs for the treatment of Parkinson's disease & Alzheimer's disease

Drugs for the treatment of Parkinson's disease and Alzheimer's disease

Drugs for the treatment of Parkinson’s disease and Alzheimer’s disease

Drugs for the treatment of Parkinson's disease

Drugs for the treatment of Parkinson’s disease

TOEFL listening material Muhammad Ali is known around the world as one of the great sports stars of the twentieth century.He needed great energy and power to become the world boxing champion. As he grew older,though,he began to change.The energy and power began to disappear.His face lost its expressiveness.His legs lost their speed. Muhammad Ali is sixty-four now and long retired from boxing.Yet it was not age that changed him so much.It was Parkinson's disease

Muhammad Ali is known around the world as one of the great sports stars of the twentieth century. He needed great energy and power to become the world boxing champion. As he grew older, though, he began to change. The energy and power began to disappear. His face lost its expressiveness. His legs lost their speed. Muhammad Ali is sixty-four now and long retired from boxing. Yet it was not age that changed him so much. It was Parkinson's disease. TOEFL listening material

AP Photo Muhammad Ali and another celebrity with Parkinson's disease,actor Michael J.Fox,before the start of a Senate hearing on the disorder in 2002

Muhammad Ali and another celebrity with Parkinson's disease, actor Michael J. Fox, before the start of a Senate hearing on the disorder in 2002

Some“well-known”PD patients The pope Paul II (Vatican A.Hitler Yasser Arafat Deng Xiaoping Chen Jingrun

The pope Paul Ⅱ(Vatican ) A. Hitler Yasser Arafat Deng Xiaoping Chen Jingrun …… Some “well-known” PD patients

What is Parkinson's disease (PD)? A progressive nervous disease occurring most often after the age of 50, associated with the destruction of brain cells that produce dopamine,and characterized by muscular tremor, slowing of movement,partial facial paralysis,peculiarity of gait(步态)t and posture,and weakness

What is Parkinson’s disease (PD)? A progressive nervous disease occurring most often after the age of 50, associated with the destruction of brain cells that produce dopamine, and characterized by muscular tremor, slowing of movement, partial facial paralysis, peculiarity of gait （步态 ） and posture, and weakness

Ventricles Thalamus Frontal cortex Substantia Nigra Striatum Hypothalamus serolonin pathwoy dopamine pathway (nigrostriatial) Brainstem dopamine pathway (mesolimbic) Which pathway?Substantia nigra-striatum pathway

Which pathway? Substantia nigra-striatum pathway

Major symptoms of PD ·rigidity(肌肉僵硬) ·bradykinesia(运动徐缓) ·resting tremor(静止性震颤) ·abnormal postural reflexes(异 常体位反射)（姿态不稳）

Major symptoms of PD • rigidity （肌肉僵硬） • bradykinesia （运动徐缓） • resting tremor （静止性震颤） • abnormal postural reflexes （ 异 常体位反射）（姿态不稳）

Illustration of Parkinson's disease by William Richard Gowers,which was first published in A Manual of Diseases of the Nervous System (1886)

Illustration of Parkinson's disease by William Richard Gowers, which was first published in A Manual of Diseases of the Nervous System （1886 ）

A man with Parkinson's disease displaying a flexed walking posture pictured in 1892.Photo appeared in Nouvelle Iconographie de la Salpetriere,vol.5

A man with Parkinson's disease displaying a flexed walking posture pictured in 1892. Photo appeared in Nouvelle Iconographie de la Salpètrière, vol. 5