上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）Anti-fungal drugs 抗真菌药

上游克通大￥ Shanghai Jiao Tong Univer Anti-fungal drugs 抗真菌药 2012.12

Anti-fungal drugs 抗真菌药 2012.12

上商充通大￥ Shanghai Jiao Tong University Dermatophytes(皮肤癣菌)

Shanghai Jiao Tong University Dermatophytes（皮肤癣菌）

上浒文通大学 Shanghai Jiao Tong University Biology of fungus Fungus:heterogeneous organisms(异养生 with eukaryotic cell wall 300,000 kinds of fungi,only 270 of which cause disease in humans and animals Systemic fungal infections(深部感染)： organ and tissue infections: Candida albicans（白念珠菌) Cuyitococcus Neofonmans(新型隐球菌)；. Topical fungal infections(表浅部感染)： ringworm(癣)

Shanghai Jiao Tong University Biology of fungus Fungus: heterogeneous organisms（异养生 物） with eukaryotic cell wall 300,000 kinds of fungi, only 270 of which cause disease in humans and animals Systemic fungal infections（深部感染）: organ and tissue infections:  Candida albicans（白念珠菌）  Cuyitococcus Neofonmans (新型隐球菌）；… Topical fungal infections（表浅部感染）: ringworm（癣）

上商充通大￥ Shanghai Jiao Tong University Tinea pedis Tinea corporis (athlete's foot) (ringworm) ADA.M. 足癣 体癣

Shanghai Jiao Tong University 足癣 体癣

上商充通大￥ Shanghai Jiao Tong University ringworm of the body(体癣)

Shanghai Jiao Tong University ringworm of the body (体癣)

上商充通大￥ Shanghai Jiao Tong University Tinea capitis(头癣)

Shanghai Jiao Tong University Tinea capitis (头癣)

上游充通大学 Fungal infections Shanghai Jiao Tong University Fungal infections has reached alarming proportions duo to a number of factors surgery operation and intensive uses of antibiotics for bacterial infections organ transplant Fungal Infections chemotherapy of cancers immune systems diseses such as AlDS

Shanghai Jiao Tong University Fungal Infections intensive uses of antibiotics for bacterial infections surgery operation and organ transplant immune systems diseses such as AIDS chemotherapy of cancers Fungal infections Fungal infections has reached alarming proportions duo to a number of factors

上游充通大 Development of anti-fungal drugs Shanghai Jiao Tong University 1903,Beurmann:potassium iodide for Sporotrichosis(孢子丝菌病) 1939,griseofulvin(灰黄霉素)discovered by British scientist 1950's,nystatin (制菌霉素)；amphotericin B(两性 霉素B) 1960's,azolee(唑类)：ketoconazole（酮康唑)， fluconazole(氟康唑)，itraconazole(伊曲康 唑)，… 2000's,caspofungin(卡泊芬净)；micafungin(米卡 芬净)，…

Shanghai Jiao Tong University Development of anti-fungal drugs 1903，Beurmann: potassium iodide for Sporotrichosis（孢子丝菌病） 1939，griseofulvin（灰黄霉素） discovered by British scientist 1950’s, nystatin（制菌霉素）; amphotericin B（两性 霉素B） 1960’s, azolee（唑类）：ketoconazole（酮康唑）， fluconazole（氟康唑），itraconazole（伊曲康 唑），… 2000’s, caspofungin（卡泊芬净）; micafungin（米卡 芬净），…

上浒文通大学 Drug classification on mechanism Shanghai Jiao Tong University Affecting cell membrane: polyenes(多烯类)：amphotericin B;nystatin azoles:clotrimazole（克霉唑)；fluconazole acrylamides:terbinafine(特比萘芬) morpholines:amorolfines (阿莫罗芬) Affecting cell wall:echinocandins(棘白菌 素类)：caspofungin(卡泊芬净)，. Others:flucytosine(氟胞嘧啶)

Shanghai Jiao Tong University Drug classification on mechanism Affecting cell membrane: • polyenes(多烯类): amphotericin B; nystatin • azoles: clotrimazole（克霉唑); fluconazole • acrylamides: terbinafine（特比萘芬） • morpholines: amorolfines （阿莫罗芬） Affecting cell wall：echinocandins（棘白菌 素类）： caspofungin（卡泊芬净), … Others: flucytosine（氟胞嘧啶）

Membrane function amphotericin B Ergosterol synthesis fluconazole itraconazole voriconazole naftifine terbinafine Cell wall synthesis Nucleic acid caspofungin synthesis 5-fluorocytosine

Shanghai Jiao Tong University Reviewing schematic