上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）Lipidemic modulating drugs Antiatherosclerotic agents

上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Lipidemic modulating drugs Antiatherosclerotic agents HANCHALAO TONG UNIVEDSES

Lipidemic modulating drugs Antiatherosclerotic agents

上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1987 2006 Causes High blood cholesterol High blood pressure Smoking Obesity Lack of physical activity AO TONG

 High blood cholesterol High blood cholesterol  High blood pressure High blood pressure  Smoking Smoking  Obesity Obesity  Lack of physical activity Lack of physical activity

7 图 上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Section 1 introduction 1.atherosclerosis Abnormal btood flow Plaque B Narrowing of artery Narrowed Plaque artery

Section 1 introduction  1.atherosclerosis 1.atherosclerosis

上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 2.the composition of blood lipid 口cholesteryl esters(CE,胆固醇酯) 口triglycerides(TG,甘油三酯)， 口cholesterol,(Ch胆固醇) IAO TONG UNIVERSITY 口phospholipids(PL磷脂)

cholesteryl esters(CE, 胆固醇酯) triglycerides (TG，甘油三酯), cholesterol, (Ch 胆固醇) phospholipids (PL磷脂） 2.the composition of blood lipid

上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Apolipoproteins(载脂蛋白) TG and CE Apoprotein ←-Cholesterol ! Oh. al, CH3 Phospholipids-

Apolipoproteins（载脂蛋白）

.cn 图 上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 3.major lipoprotein classes: chylomicron,VLDL,IDL,LDL,HDL n CHANCHALIAO TONG UNIVEDSY

3. major lipoprotein classes: 3. major lipoprotein classes:  chylomicron , VLDL, IDL, LDL, HDL chylomicron , VLDL, IDL, LDL, HDL

上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Lipoprotein pathways Exogenous Endogenous Dietary fat Bile acid + M Cholesterol Intestine LDL Tissue Liver Chylomicron Remnant VLDL IDL HDL Lipoprotein Lipoprotein lipase lipase Fat FFA Fat FFA Muscle Muscle

图 上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 4.the action of lipoprotein in atherosclerosis formation VLDL,LDL,IDL,apoB LAA AA自0NC HDL,apoA

4. the action of lipoprotein in 4. the action of lipoprotein in atherosclerosis formation atherosclerosis formation  VLDL, LDL, IDL, apoB VLDL, LDL, IDL, apoB  HDL, apoA HDL, apoA

上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 5.forms of hyperlipoproteinemia form Lipoprotein plasma lipid abnormality abnormality I CM TG 11 TC Ⅲa LDL Tc it IIb VLDL,LDL TG 11 TC1t Ⅲ IDL 1三 TG ITCi IV VLDL TG i V CM,VLDL AO TOW TG TC↑

5. forms of hyperlipoproteinemia form Lipoprotein Lipoprotein abnormality abnormality plasma lipid plasma lipid abnormality abnormality I CM TG TC TG TC IIa LDL TC IIb VLDL, LDL VLDL, LDL TG TC TG TC III IDL TG TC TG TC IV VLDL TG V CM, VLDL CM, VLDL TG TC TG TC

上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Resins Fibrates Dietary fat M Bile'acid Intestine LDL Tissue Liver Ezetimibe Chylomicron Remnant VLDL IDL HDL Lipoprotein Lipoprotein lipase lipase Fat FFA Fat FFA Muscle Muscle HMG CoA reductase inhibitors statins