上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）Chapter 1：Introduction to Pharmacology、Chapter 2：Pharmacokinetics（1）

Chapter 1: Introduction to Pharmacology Prof.R.D.Ye 2012-09-10

Chapter 1: Introduction to Pharmacology Prof. R.D. Ye 2012-09-10

药理学教学安排 ·参讲教师：叶德全教授yedequan@sjtu.edu.cn 殷明教授myin@sjtu.edu.cn 孙海荚副教授hysun@sju.edu.cn 李欣燕讲师lixy@sjtu.edu.cn ·授课时段：2011.9.10-2011.12.26 What's new this year? English teaching

药理学教学安排 • 参讲教师: 叶德全 教授 yedequan@sjtu.edu.cn 殷 明 教授 myin@sjtu.edu.cn 孙海英 副教授 hysun@sjtu.edu.cn 李欣燕 讲师 lixy@sjtu.edu.cn • 授课时段： 2011.9.10 - 2011.12.26 What’s new this year? English teaching

双语教学向全英语教学的转变 ·培养学生的英语学习能力，缩小与发达国家药学教学的差距 ·克服双语教学过程中，学生一边看英文PPT,一边听中文讲解 所造成的困难 ·英语教材由任课教师编写有关章节，其它教材补充 ·中文辅助教材：《药理学》，人民卫生出版社第七版 朱依谆、殷明主编 。 测验与考试：两次测验，第一次比重降低(20%)，内容相应 减少；第二次占40% ·期末考试：占总分的40%，时间根据学校安排另行通知

双语教学向全英语教学的转变 • 培养学生的英语学习能力，缩小与发达国家药学教学的差距 • 克服双语教学过程中，学生一边看英文PPT，一边听中文讲解 所造成的困难 • 英语教材由任课教师编写有关章节;其它教材补充 • 中文辅助教材：《药理学》，人民卫生出版社第七版 朱依谆、殷 明 主编 • 测验与考试：两次测验，第一次比重降低（20%），内容相应 减少；第二次占40% • 期末考试：占总分的40%，时间根据学校安排另行通知

What is Pharmacology? Pharmacology a scientific discipline that studies drug action mechanism Drugs are chemical substances that alter the basic functions of the body. There is no definitive line between drug,food and poison On a pharmacological term,drugs are chemicals that have therapeutic functions

What is Pharmacology? • Pharmacology a scientific discipline that studies drug action mechanism • Drugs are chemical substances that alter the basic functions of the body. • There is no definitive line between drug, food and poison • On a pharmacological term, drugs are chemicals that have therapeutic functions

Divisions of pharmacology Clinical pharmacology (in vivo drug action) Toxicology (harmful effect of a drug on body) Pharmacogenetics(genetic variations that alter response of body to drugs) Pharmacogenomics (use genomics approach to identify and characterize new drugs) Neuropharmacology,immunopharmacology, etc (study drug effects in respective systems)

Divisions of pharmacology • Clinical pharmacology (in vivo drug action) • Toxicology (harmful effect of a drug on body) • Pharmacogenetics (genetic variations that alter response of body to drugs) • Pharmacogenomics (use genomics approach to identify and characterize new drugs) • Neuropharmacology, immunopharmacology, etc (study drug effects in respective systems)

Pharmacology and Medicine ·Chemicals→drugs(preclinical:PK,PD,Tox) Clinical Phase I:clinical pharm.(safe dosage, maximal dose without obvious side-effect) Clinical Phase ll:Efficacy in clinical treatment, small group (~100)of patients . Clinical Phase lll:Large group,full evaluation Clinical Phase IV:Post-marketing clinical monitoring

Pharmacology and Medicine • Chemicals → drugs (preclinical:PK, PD, Tox) • Clinical Phase I: clinical pharm. (safe dosage, maximal dose without obvious side‐effect) • Clinical Phase II: Efficacy in clinical treatment, small group (~100) of patients • Clinical Phase III: Large group, full evaluation • Clinical Phase IV: Post‐marketing clinical monitoring

How to study pharmacology? Learn physiology,then pharmacology Know drug mechanisms,not just memorizing Experiment,if you can(work in laboratory) Learn great findings in pharmacology Understand the chemical and structural basis of drug action Be open-minded,identify new trends Problem-based learning

How to study pharmacology? • Learn physiology, then pharmacology • Know drug mechanisms, not just memorizing • Experiment, if you can (work in laboratory) • Learn great findings in pharmacology • Understand the chemical and structural basis of drug action • Be open‐minded, identify new trends • Problem‐based learning

Chapter 2: Pharmacokinetics (1) Prof.R.D.Ye 2012-10-10to12

Chapter 2: Pharmacokinetics (1) Prof. R.D. Ye 2012-10-10 to 12

Pharmacokinetics Drug disposition ADME ·Absorption ·Distribution Metabolism (biotransformation) ·Excretion Quantification of drug concentration in the body,and mathematic modeling

Pharmacokinetics • Drug disposition = ADME • Absorption • Distribution • Metabolism (biotransformation) • Excretion • Quantification of drug concentration in the body, and mathematic modeling

ADME of a drug taken orally Oral administration Blood Bound drug Excretion Gut Absorption Free drug Metabolite Urine Distribution Biotransformation Target organ Liver

ADME of a drug taken orally