上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）Hypnotics & anxiolytics

殷明，医学博士 药理学教授 34206836 myin@sjtu.edu.cn

殷明，医学博士 药理学教授 34206836 myin@sjtu.edu.cn

Something need to know PPT preparation mainly based on "Textbook of clinical pharmacology and therapeutics” Review and examination also based on PPT and "Textbook of clinical pharmacology and therapeutics' 《药理学》（第7版，2011.8，人民卫生出 版社)作为参考书

Something need to know • PPT preparation mainly based on “Textbook of clinical pharmacology and therapeutics” • Review and examination also based on PPT and “Textbook of clinical pharmacology and therapeutics” • 《药理学》（第7版，2011.8，人民卫生出 版社）作为参考书

My opinion on pharmacology study Mechanism-based category of drugs (action patterns),not just drug names Pharmacodynamics (major pharmacological actions)&typical clinical uses Pharmacokinetic features,not parameters Important adverse drug reactions

My opinion on pharmacology study • Mechanism-based category of drugs (action patterns), not just drug names • Pharmacodynamics (major pharmacological actions) & typical clinical uses • Pharmacokinetic features, not parameters • Important adverse drug reactions

Introduction to Central Nervous System Hypnotics and anxiolytics 2012.10.24

Introduction to Central Nervous System Hypnotics and anxiolytics 2012.10.24

We need to know after study of neuropharmacology Route of a centrally acting drug into brain? How a centrally acting drug usually do in CNS and/or in the periphery? ·Others?

We need to know after study of neuropharmacology • Route of a centrally acting drug into brain? • How a centrally acting drug usually do in CNS and/or in the periphery? • Others?

Anatomy of human brain Cerebrum Corpus callosum Thalamus Cerebellum Sagittal view Pituitary Me dulla gland oblongata Pons Spinal cord ADAM

Anatomy of human brain Sagittal view

Cerebral cortex Evolutionally formed last Receiving and processing information Control of sight,listening, movement,memory,wake, autonomic function

• Evolutionally formed last • Receiving and processing information • Control of sight, listening, movement, memory, wake, autonomic function… Cerebral cortex

Limbic system Cingulate /Fornix A group of gyrusy Pinealgland interconnected deep brain structures, common to all mammals,and involved Mammillary in olfaction,emotion, Thalamus body人 motivation,behavior, Pituitary gland and various autonomic Hypothalamus functions. Amygdala Hippocampus The Limbic System

A group of interconnected deep brain structures, common to all mammals, and involved in olfaction, emotion, motivation, behavior, and various autonomic functions. Limbic system

Cerebellum Responsible for the regulation and coordination of complex voluntary muscular movement as well as the maintenance of posture and balance. More study indicating its involvement in psychiatric conditions

Responsible for the regulation and coordination of complex voluntary muscular movement as well as the maintenance of posture and balance. Cerebellum More study indicating its involvement in psychiatric conditions

Diencephalon >major divisions:thalamus and hypothalamus functioning: as a relay system between sensory input neurons and other parts of the brain as an interactive site for the central nervous and endocrine systems >working in tandem with the limbic system

major divisions: thalamus and hypothalamus  functioning: • as a relay system between sensory input neurons and other parts of the brain • as an interactive site for the central nervous and endocrine systems working in tandem with the limbic system Diencephalon