上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）抗肿瘤药物 Anti-neoplastic drugs

上泽充通大学 Shanghai Jiao Tong Univer. Anti-neoplastic drugs 抗肿瘤药物 2011.12

Anti-neoplastic drugs 抗肿瘤药物 2011.12

上泽充通大睾 讨论题 后 Shanghai Jiao Tong University 从不感冒者得癌症的机会大，还是易 患感冒者得癌症机会大？ 为什么？ 过敏发生率，发达国家发生率高，还是贫 困国家高？

Shanghai Jiao Tong University 讨论题 从不感冒者得癌症的机会大，还是易 患感冒者得癌症机会大？ 为什么？ 过敏发生率，发达国家发生率高，还是贫 困国家高？

上泽充通大睾 Shanghai Jiao Tong University 生物学“僭越效应”。 僭越：超越本分 “不干不净，吃了没病”。一定病菌刺激可以使人体免 疫系统功能增强。 过敏发生率：发达国家儿童发生率高于贫困国家 金丝桃中的抗抑郁成分受到一定刺激如昆虫袭击后，含 量会增加 从不感冒者患癌症机会大5倍，因为感冒促使干扰素产生。 砷剂少量应用，促白细胞分化，治疗白血病

Shanghai Jiao Tong University 生物学“僭越效应” 。 僭越：超越本分 “不干不净，吃了没病” 。一定病菌刺激可以使人体免 疫系统功能增强。 过敏发生率：发达国家儿童发生率高于贫困国家 金丝桃中的抗抑郁成分受到一定刺激如昆虫袭击后，含 量会增加 从不感冒者患癌症机会大5倍，因为感冒促使干扰素产生。 砷剂少量应用，促白细胞分化，治疗白血病

上浒文通大学 Shanghai Jiao Tong University hy_cancer happens？ 人体：1000万亿个细胞 病毒、霉菌、射线、化学致癌剂；遗传因素；免 疫功能低下..直接、间接影响DNA >3000万个癌变细胞，可能成为癌症 Women who inherit a single defective copy of either of the tumor suppressor genes BRCA1 and BRCA2 have a significantly increased risk of developing breast cancer

Shanghai Jiao Tong University 人为什么会生癌 人体：1000万亿个细胞 病毒、霉菌、射线、化学致癌剂; 遗传因素；免 疫功能低下……直接、间接影响DNA >3000万个癌变细胞，可能成为癌症 Women who inherit a single defective copy of either of the tumor suppressor genes BRCA1 and BRCA2 have a significantly increased risk of developing breast cancer. Why cancer happens?

上游充通大 Cancer 后 Shanghai Jiao Tong University Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival,proliferation,and differentiation. 1.uncontrolled proliferation 2.dedifferentiation(去分化)and loss of function 3.invasiveness 4.metastasis（转移)

Shanghai Jiao Tong University Cancer Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival, proliferation, and differentiation. 1. uncontrolled proliferation 2. dedifferentiation（去分化） and loss of function 3. invasiveness 4. metastasis（转移）

上商充通大￥ What Is Metastasis? 1.Cancer cells Blood invade surrounding vessel tissues and vessels 2.Cancer cells are transported by the circulatory system to distant sites 3.Cancer cells reinvade and grow at new location

Shanghai Jiao Tong University

h 上浒充通大学 后 Shanghai Jiao Tong University Basic facts of cancer most common cause of death from disease 国第一位死因；死180万/年) morbidity getting higher gradually chemotherapy,some curative,others palliative almost all the anticancer drugs can be produced in China 国际抗癌联盟第21届世界抗癌大会，2010,8月18日-21 日，中国 2008,全球1270万人患癌，死760万

Shanghai Jiao Tong University Basic facts of cancer ü most common cause of death from disease （中 国第一位死因；死180万/年） ü morbidity getting higher gradually ü chemotherapy, some curative, others palliative ü almost all the anticancer drugs can be produced in China ü 国际抗癌联盟第21届世界抗癌大会，2010，8月18日-21 日，中国 ü 2008，全球1270万人患癌，死760万

上游充通大￥ 后 Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. Cancer Liver cancer Lung cancer 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles

Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles. Cancer Liver cancer Lung cancer

上浒充通大￥ Causes of cancer Shanghai Jiao Tong University genetic predisposition:tumor suppressor genes deleted or damaged,etc. exposure to environmental carcinogens: radiation,chemicals (including ones in food), viruses,.. In a healthy body immune system can recognize and destroy foreign cells.If 注意生活方式（吸烟；肥胖；）因素、传染病 等感染因素、职业或环境因素 √ 1/5癌症由慢性感染引起，如人类乳头瘤病毒引 起宫颈癌；乙肝病毒引起肝癌

Shanghai Jiao Tong University Causes of cancer ü genetic predisposition: tumor suppressor genes deleted or damaged, etc. ü exposure to environmental carcinogens: radiation, chemicals (including ones in food), viruses, … ü In a healthy body immune system can recognize and destroy foreign cells. If … ü 注意生活方式（吸烟；肥胖；…）因素、传染病 等感染因素、职业或环境因素 ü 1／5癌症由慢性感染引起，如人类乳头瘤病毒引 起宫颈癌；乙肝病毒引起肝癌

上游充通大￥ Shanghai Jiao Tong University radiotherapy chemotherapy free radicals replisome stalling alkylation environmental damage toxins replication UV light errors bulky adducts strand O-methyl breaks guanine pyrimidine dimers mismatches insertions/deletions

Shanghai Jiao Tong University